DNA methylation in spermatogenesis and male infertility (Review)

  • Authors:
    • Xiangrong Cui
    • Xuan Jing
    • Xueqing Wu
    • Meiqin Yan
    • Qiang Li
    • Yan Shen
    • Zhenqiang Wang
  • View Affiliations

  • Published online on: August 4, 2016     https://doi.org/10.3892/etm.2016.3569
  • Pages: 1973-1979
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Abstract

Infertility is a significant problem for human reproduction, with males and females equally affected. However, the molecular mechanisms underlying male infertility remain unclear. Spermatogenesis is a highly complex process involving mitotic cell division, meiosis cell division and spermiogenesis; during this period, unique and extensive chromatin and epigenetic modifications occur to bring about specific epigenetic profiles in spermatozoa. It has recently been suggested that the dysregulation of epigenetic modifications, in particular the methylation of sperm genomic DNA, may serve an important role in the development of numerous diseases. The present study is a comprehensive review on the topic of male infertility, aiming to elucidate the association between sperm genomic DNA methylation and poor semen quality in male infertility. In addition, the current status of the genetic and epigenetic determinants of spermatogenesis in humans is discussed.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Cui X, Jing X, Wu X, Yan M, Li Q, Shen Y and Wang Z: DNA methylation in spermatogenesis and male infertility (Review). Exp Ther Med 12: 1973-1979, 2016
APA
Cui, X., Jing, X., Wu, X., Yan, M., Li, Q., Shen, Y., & Wang, Z. (2016). DNA methylation in spermatogenesis and male infertility (Review). Experimental and Therapeutic Medicine, 12, 1973-1979. https://doi.org/10.3892/etm.2016.3569
MLA
Cui, X., Jing, X., Wu, X., Yan, M., Li, Q., Shen, Y., Wang, Z."DNA methylation in spermatogenesis and male infertility (Review)". Experimental and Therapeutic Medicine 12.4 (2016): 1973-1979.
Chicago
Cui, X., Jing, X., Wu, X., Yan, M., Li, Q., Shen, Y., Wang, Z."DNA methylation in spermatogenesis and male infertility (Review)". Experimental and Therapeutic Medicine 12, no. 4 (2016): 1973-1979. https://doi.org/10.3892/etm.2016.3569