Rotavirus‑associated immune thrombocytopenic purpura in children: A retrospective study

Ai,Qi; Yin,Jing; Chen,Sen; Qiao,Lijin; Luo,Na

doi:10.3892/etm.2016.3582

October-2016 Volume 12 Issue 4

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October-2016 Volume 12 Issue 4

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Article

Rotavirus‑associated immune thrombocytopenic purpura in children: A retrospective study

Authors:
- Qi Ai
- Jing Yin
- Sen Chen
- Lijin Qiao
- Na Luo
View Affiliations / Copyright

Affiliations: Department of Hematology, Tianjin Children's Hospital, Tianjin 301800, P.R. China, Department of Rheumatology, Tianjin Children's Hospital, Tianjin 301800, P.R. China, Department of Immunology, School of Medicine, Nankai University, Tianjin 300071, P.R. China
Pages: 2187-2190
|
Published online on: August 9, 2016

https://doi.org/10.3892/etm.2016.3582
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Abstract

Certain studies have previously indicated that an association may exist between rotavirus infection and primary immune thrombocytopenic purpura (ITP). The present retrospective study aimed to investigate whether rotavirus may cause ITP in children. Firstly, the incidence of ITP in children with or without rotavirus diarrhea was compared. A 14.58% incident rate was observed in children with rotavirus diarrhea compared with a 7.22% incident rate in children without rotavirus diarrhea. Subsequently, the clinical features of ITP children with or without rotavirus infection were compared. The results indicated that ITP children with rotavirus infection were significantly younger, showed significantly decreased mean platelet volume (MPV) levels and presented a significantly higher frequency of bleeding score of 3 against ITP children without rotavirus infection. In conclusion, these findings suggest that rotavirus serves a causative role in ITP.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Rotavirus‑associated immune thrombocytopenic purpura in children: A retrospective study

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