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October-2016 Volume 12 Issue 4

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Article

Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis

  • Authors:
    • Hui‑Bing Zhang
    • Juan Chen
    • Qiao‑Fen Lan
    • Xiong‑Jian Ma
    • Shi‑Yan Zhang
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory, Affiliated Fuding Hospital, Fujian University of Traditional Chinese Medicine, Fuding, Fujian 355200, P.R. China
  • Pages: 2215-2219
    |
    Published online on: August 10, 2016
       https://doi.org/10.3892/etm.2016.3583
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Abstract

The aim of this study was to evaluate the diagnostic efficiency of red blood cell distribution width (RDW), platelet distribution width (PDW), the neutrophil‑lymphocyte count ratio (NLCR), procalcitonin (PCT) and C‑reactive protein (CRP) for the prediction of sepsis. A total of 120 consecutive patients who underwent blood culture testing were included. The PCT and CRP levels, and RDW, PDW and NLCR percentages were determined and compared between patients with positive blood cultures and those without. The PCT, CRP, RDW, PDW and NLCR values were significantly higher in patients with positive blood culture compared with those without. PCT and NLCR each had a high diagnostic performance for the prediction of sepsis, with an area under the curve (AUC) for sepsis of 0.829 and 0.718, respectively. A combination of RDW, PDW and NLCR also exhibited a good diagnostic performance for sepsis (AUC, 0.704). NLCR is easily obtained by automated hematological analysis. Moreover, NLCR was found to have a high diagnostic efficiency for the prediction of sepsis, with greater sensitivity and accuracy than CRP. In conclusion, PCT exhibited the optimal diagnostic performance among the tested markers. The combination of the three parameters of RDW, PDW and NLCR, demonstrated a high diagnostic performance similar to that of PCT.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang HB, Chen J, Lan QF, Ma XJ and Zhang SY: Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis. Exp Ther Med 12: 2215-2219, 2016.
APA
Zhang, H., Chen, J., Lan, Q., Ma, X., & Zhang, S. (2016). Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis. Experimental and Therapeutic Medicine, 12, 2215-2219. https://doi.org/10.3892/etm.2016.3583
MLA
Zhang, H., Chen, J., Lan, Q., Ma, X., Zhang, S."Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis". Experimental and Therapeutic Medicine 12.4 (2016): 2215-2219.
Chicago
Zhang, H., Chen, J., Lan, Q., Ma, X., Zhang, S."Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2215-2219. https://doi.org/10.3892/etm.2016.3583
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang HB, Chen J, Lan QF, Ma XJ and Zhang SY: Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis. Exp Ther Med 12: 2215-2219, 2016.
APA
Zhang, H., Chen, J., Lan, Q., Ma, X., & Zhang, S. (2016). Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis. Experimental and Therapeutic Medicine, 12, 2215-2219. https://doi.org/10.3892/etm.2016.3583
MLA
Zhang, H., Chen, J., Lan, Q., Ma, X., Zhang, S."Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis". Experimental and Therapeutic Medicine 12.4 (2016): 2215-2219.
Chicago
Zhang, H., Chen, J., Lan, Q., Ma, X., Zhang, S."Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2215-2219. https://doi.org/10.3892/etm.2016.3583
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