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Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study

  • Authors:
    • Tommaso Cai
    • Paolo Verze
    • Paolo Massenio
    • Daniele Tiscione
    • Gianni Malossini
    • Luigi Cormio
    • Giuseppe Carrieri
    • Vincenzo Mirone
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Santa Chiara Regional Hospital, I‑38123 Trento, Italy, Department of Urology, University Federico II of Naples, I-80121 Naples, Italy, Department of Urology and Renal Transplantation, University of Foggia, I‑71121 Foggia, Italy
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2083-2087
    |
    Published online on: August 12, 2016
       https://doi.org/10.3892/etm.2016.3595
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Abstract

The therapeutic armamentarium currently available for the treatment of premature ejaculation (PE) is not highly satisfactory. However, phytotherapeutics appear to be an interesting option for PE management. The present study aimed to evaluate the tolerability and efficacy of a phytotherapeutic combination of Rhodiola rosea, folic acid, biotin and zinc (EndEP®) in the treatment of patients affected by lifelong PE. All patients affected by lifelong PE who were attending three Urological Institutions from July to December 2014 were enrolled in this prospective, multicentre, phase I‑II study. All patients were assigned to receive oral tablets of EndEP® (one tablet per day) for 90 days. Clinical and instrumental analyses were carried out at enrolment and at the end of the study. International Prostatic Symptom Score (IPSS), International Index of Erectile Function (IIEF)‑15, Premature Ejaculation Diagnostic Tool (PEDT) and Short Form (SF)‑36 questionnaires were used. The intravaginal ejaculation latency time (IELT) for each event was also evaluated using the stop‑watch technique. The main outcome measure was the difference from baseline in PEDT questionnaire and mean IELT at the end of the follow‑up period. In total, 91 patients (mean age, 32.3±5.6 years) were analysed. The baseline questionnaires mean scores were 1.1±1.6, 26.1±2.9, 15.3±3.4 and 98.2±0.5, for IPSS, IIEF‑15, PEDT and SF‑36, respectively. The mean IELT at baseline was 73.6±46.9s. At the follow‑up examination (90 days after the start of treatment), no statistically significant differences were identified in terms of IPSS (1.4±1.5) or IIEF‑15 (26.3±3.1) compared with the pre‑treatment values (P=0.19 and P=0.64, respectively). A statistically significant difference was detected between the mean IELT at enrolment and after treatment (73.6±46.9 vs. 102.3±60.0; P<0.001) and SF‑36 questionnaire (98.2±0.5 vs. 99.4±0.1; P<0.001). Fifty‑five patients reported improvement in the control of ejaculation (60.4%). Very few adverse events were reported (4.4%). In conclusion, it was found that EndEP® significantly improved ejaculatory control and the quality of sexual life in patients affected by lifelong PE, with a very low rate of adverse events.
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1 

Laumann EO, Nicolosi A, Glasser DB, Paik A, Gingell C, Moreira E and Wang T: GSSAB Investigators' Group: Sexual problems among women and men aged 40–80 y: Prevalence and correlates identified in the global study of sexual attitudes and behaviors. Int J Impot Res. 17:39–57. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S and Alexander J: The Premature ejaculation prevalence and attitudes (PEPA) survey: Prevalence, comorbidities and professional help-seeking. Eur Urol. 51:816–823. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, Vardi Y and Wespes E: European Association of Urology: Guidelines on male sexual dysfunction: Erectile dysfunction and premature ejaculation. Eur Urol. 57:804–814. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Serefoglu EC, McMahon CG, Waldinger MD, Althof SE, Shindel A, Adaikan G, Becher EF, Dean J, Giuliano F, Hellstrom WJ, et al: An evidence-based unified definition of lifelong and acquired premature ejaculation: Report of the second international society for sexual medicine Ad Hoc committee for the definition of premature ejaculation. J Sex Med. 11:1423–1441. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Mondaini N, Fusco F, Cai T, Benemei S, Mirone V and Bartoletti R: Dapoxetine treatment in patients with lifelong premature ejaculation: The reasons of a ‘Waterloo’. Urology. 82:620–624. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Mannucci C, Navarra M, Calzavara E, Caputi AP and Calapai G: Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats. Phytomedicine. 19:1117–1124. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Chen QG, Zeng YS, Qu ZQ, Tang JY, Qin YJ, Chung P, Wong R and Hägg U: The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine. 16:830–838. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Yin TL, Yang J, Zhang B, Yan WJ, Xu WM, Li W, Yu L, Li SJ and Wu GX: Folic acid supplementation as adjunctive treatment premature ejaculation. Med Hypotheses. 76:414–416. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Denisow B and Denisow-Pietrzyk M: Biological and therapeutic properties of bee pollen. A review. J Sci Food Agric. Mar 25–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

10 

Kolenko V, Teper E, Kutikov A and Uzzo R: Zinc and zinc transporters in prostate carcinogenesis. Nat Rev Urol. 10:219–226. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Cai T, Pisano F, Magri V, Verze P, Mondaini N, D'Elia C, Malossini G, Mazzoli S, Perletti G, Gontero P, et al: Chlamydia trachomatis infection is related to premature ejaculation in chronic prostatitis patients: Results from a cross-sectional study. J Sex Med. 11:3085–3092. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Badia X, Garcia-Losa M and Dal-Re R: Ten-language translation and harmonization of the International Prostate Symptom Score: Developing a methodology for multinational clinical trials. Eur Urol. 31:129–140. 1997.PubMed/NCBI

13 

Cappelleri JC, Rosen RC, Smith MD, Mishra A and Osterloh IH: Diagnostic evaluation of the erectile function domain of the international index of erectile function. Urology. 54:346–351. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Symonds T, Perelman MA, Althof S, Giuliano F, Martin M, May K, Abraham L, Crossland A and Morris M: Development and validation of a premature ejaculation diagnostic tool. Eur Urol. 52:565–573. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Jannini EA, Maggi M and Lenzi A: Evaluation of premature ejaculation. J Sex Med. 8(Suppl 4): 328–334. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Apolone G and Mosconi P: The italian SF-36 health survey: Translation, validation and norming. J Clin Epidemiol. 51:1025–1036. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Pastore AL, Palleschi G, Fuschi A, Maggioni C, Rago R, Zucchi A, Costantini E and Carbone A: Pelvic floor muscle rehabilitation for patients with lifelong premature ejaculation: A novel therapeutic approach. Ther Adv Urol. 6:83–88. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Fiamegos YC, Nanos CG, Vervoort J and Stalikas CD: Analytical procedure for the in-vial derivatization-extraction of phenolic acids and flavonoids in methanolic and aqueous plant extracts followed by gas chromatography with mass-selective detection. J Chromatogr A. 1041:11–18. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Yang DY, Ko K, Lee WK, Park HJ, Lee SW, Moon KH, Kim SW, Kim SW, Cho KS, Moon du G, et al: Urologist's practice patterns including surgical treatment in the management of premature ejaculation: A korean nationwide survey. World J Mens Health. 31:226–231. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Waldinger MD, Hengeveld MW, Zwinderman AH and Olivier B: Effect of SSRI antidepressants on ejaculation: A double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine and sertraline. J Clin Psychopharmacol. 18:274–281. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Shindel A, Nelson C and Brandes S: Urologist practice patterns in the management of premature ejaculation: A nationwide survey. J Sex Med. 5:199–205. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Allard J, Truitt WA, McKenna KE and Coolen LM: Spinal cord control of ejaculation. World J Urol. 23:119–126. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Hung SK, Perry R and Ernst E: The effectiveness and efficacy of Rhodiola rosea L.: A systematic review of randomized clinical trials. Phytomedicine. 18:235–244. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Ishaque S, Shamseer L, Bukutu C and Vohra S: Rhodiola rosea for physical and mental fatigue: A systematic review. BMC Complement Altern Med. 12:702012. View Article : Google Scholar : PubMed/NCBI

25 

Brocardo PS, Budni J, Kaster MP, Santos AR and Rodrigues AL: Folic acid administration produces an antidepressant-like effect in mice: Evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 54:464–473. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Yan WJ, Yu N, Yin TL, Zou YJ and Yang J: A new potential risk factor in patients with erectile dysfunction and premature ejaculation: Folate deficiency. Asian J Androl. 16:902–906. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Omu AE, Al-Bader AA, Dashti H and Oriowo MA: Magnesium in human semen: Possible role in premature ejaculation. Arch Androl. 46:59–66. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Kelleher SL, McCormick NH, Velasquez V and Lopez V: Zinc in specialized secretory tissues: Roles in the pancreas, prostate and mammary gland. Adv Nutr. 2:101–111. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Delost P and Terroine T: On the origin of male sexual disorders due to a biotin deficiency. Hormone and vitamin treatments. Arch Sci Physiol (Paris). 23:243–268. 1969.(In French). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cai T, Verze P, Massenio P, Tiscione D, Malossini G, Cormio L, Carrieri G and Mirone V: Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study. Exp Ther Med 12: 2083-2087, 2016.
APA
Cai, T., Verze, P., Massenio, P., Tiscione, D., Malossini, G., Cormio, L. ... Mirone, V. (2016). Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study. Experimental and Therapeutic Medicine, 12, 2083-2087. https://doi.org/10.3892/etm.2016.3595
MLA
Cai, T., Verze, P., Massenio, P., Tiscione, D., Malossini, G., Cormio, L., Carrieri, G., Mirone, V."Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study". Experimental and Therapeutic Medicine 12.4 (2016): 2083-2087.
Chicago
Cai, T., Verze, P., Massenio, P., Tiscione, D., Malossini, G., Cormio, L., Carrieri, G., Mirone, V."Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2083-2087. https://doi.org/10.3892/etm.2016.3595
Copy and paste a formatted citation
x
Spandidos Publications style
Cai T, Verze P, Massenio P, Tiscione D, Malossini G, Cormio L, Carrieri G and Mirone V: Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study. Exp Ther Med 12: 2083-2087, 2016.
APA
Cai, T., Verze, P., Massenio, P., Tiscione, D., Malossini, G., Cormio, L. ... Mirone, V. (2016). Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study. Experimental and Therapeutic Medicine, 12, 2083-2087. https://doi.org/10.3892/etm.2016.3595
MLA
Cai, T., Verze, P., Massenio, P., Tiscione, D., Malossini, G., Cormio, L., Carrieri, G., Mirone, V."Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study". Experimental and Therapeutic Medicine 12.4 (2016): 2083-2087.
Chicago
Cai, T., Verze, P., Massenio, P., Tiscione, D., Malossini, G., Cormio, L., Carrieri, G., Mirone, V."Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2083-2087. https://doi.org/10.3892/etm.2016.3595
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