Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review

Mo,Zhiming; Dong,Yaxian; Chen,Xiaolian; Yao,Huiyan; Zhang,Bin

doi:10.3892/etm.2016.3604

October-2016 Volume 12 Issue 4

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October-2016 Volume 12 Issue 4

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Case Report

Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review

Authors:
- Zhiming Mo
- Yaxian Dong
- Xiaolian Chen
- Huiyan Yao
- Bin Zhang
View Affiliations / Copyright

Affiliations: Department of Neurology, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China
Pages: 2331-2335
|
Published online on: August 22, 2016

https://doi.org/10.3892/etm.2016.3604
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Abstract

Acute transverse myelitis is a rare manifestation of dengue infection. To the best of our knowledge, only 6 cases of acute transverse myelitis as a manifestation of dengue infection have been reported thus far. The present study described a case of acute transverse myelitis complicated with subacute thyroiditis 6 days after the onset of dengue viral infection. In addition, the available literature was searched to identify similar previous cases. Treatment with intravenous pulse methylprednisolone immunoglobulin plasmapheresis and physiotherapy resulted in partial recovery at 3 months post‑infection. In conclusion, the involvement of dengue infection should be considered in patients who develop central nervous system manifestations during or after the recovery period of dengue infection. Furthermore, since methylprednisolone and immunoglobulin are effective during the active phase of the infection, prompt diagnosis and initiation of treatment are crucial.

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1	Murthy JM: Neurological complication of dengue infection. Neurol India. 58:581–584. 2010. View Article : Google Scholar : PubMed/NCBI
2	Gulati S and Maheshwari A: Atypical manifestations of dengue. Trop Med Int Health. 12:1087–1095. 2007. View Article : Google Scholar : PubMed/NCBI
3	Solomon T, Dung NM, Vaughn DW, Kneen R, Thao LT, Raengsakulrach B, Loan HT, Day NP, Farrar J, Myint KS, et al: Neurological manifestations of dengue infection. Lancet. 355:1053–1059. 2000. View Article : Google Scholar : PubMed/NCBI
4	Misra UK, Kalita J, Syam UK and Dhole TN: Neurological manifestations of dengue virus infection. J Neurol Sci. 244:117–122. 2006. View Article : Google Scholar : PubMed/NCBI
5	Soares CN, Faria LC, Peralta JM, de Freitas MR and Puccioni-Sohler M: Dengue infection: Neurological manifestations and cerebrospinal fluid (CSF) analysis. J Neurol Sci. 249:19–24. 2006. View Article : Google Scholar : PubMed/NCBI
6	de Sousa A Miranda, Puccioni-Sohler M, Dias Borges A, Adorno L Fernandes, Alvarenga M Papais and Alvarenga RM Papais: Post-dengue neuromyelitis optica: Case report of a Japanese-descendent Brazilian child. J Infect Chemother. 12:396–398. 2006. View Article : Google Scholar : PubMed/NCBI
7	Williams M: Manual muscle testing, development and current use. Phys Ther Rev. 36:797–805. 1956.PubMed/NCBI
8	Seet RC, Lim EC and Wilder-Smith EP: Acute transverse myelitis following dengue virus infection. J Clin Virol. 35:310–312. 2006. View Article : Google Scholar : PubMed/NCBI
9	Larik A, Chiong Y, Lee LC and Ng YS: Longitudinally extensive transverse myelitis associated with dengue fever. BMJ Case Rep. 2012.pii:bcr1220115378. 2012.
10	Chanthamat N and Sathirapanya P: Acute transverse myelitis associated with dengue viral infection. J Spinal Cord Med. 33:425–427. 2010. View Article : Google Scholar : PubMed/NCBI
11	Renganathan A, Ng WK and Tan CT: Transverse myelitis in association with dengue infection. Neurol J Southeast Asia. 1:61–63. 1996.
12	Kunishige M, Mitsui T, Tan BH, Leong HN, Takasaki T, Kurane I, Mihara A and Matsumoto T: Preferential gray matter involvement in dengue myelitis. Neurology. 63:1980–1981. 2004. View Article : Google Scholar : PubMed/NCBI
13	Leão RN, Oikawa T, Rosa ES, Yamaki JT, Rodrigues SG, Vasconcelos HB, Sousa MRS, Tsukimata JK, Azevedo RSS and Vasconcelos PFC: Isolation of dengue 2 virus from a patient with central nervous system involvement (transverse myelitis). Rev Soc Bras Med Trop. 35:401–404. 2002. View Article : Google Scholar : PubMed/NCBI
14	Lee IK, Liu JW and Yang KD: Fatal dengue hemorrhagic fever in adults: Emphasizing the evolutionary pre-fatal clinical and laboratory manifestations. PLoS Negl Trop Dis. 6:e15322012. View Article : Google Scholar : PubMed/NCBI
15	Assir MZ, Jawa A and Ahmed HI: Expanded dengue syndrome: Subacute thyroiditis and intracerebral hemorrhage. BMC Infect Dis. 12:2402012. View Article : Google Scholar : PubMed/NCBI
16	Sindic CJ, Van Antwerpen MP and Goffette S: The intrathecal humoral immune response: Laboratory analysis and clinical relevance. Clin Chem Lab Med. 39:333–340. 2001. View Article : Google Scholar : PubMed/NCBI
17	Lazarus JH: Silent thyroiditis and subacute thyroiditisWerner & Ingbar's The Thyroid: A Fundamental and Clinical Text. Braverman LE and Utiger RD: 7th. Lippincott-Raven; Philadelphia, PA: pp. 577–591. 1996
18	Desailloud R and Hober D: Viruses and thyroiditis: An update. Virol J. 6:52009. View Article : Google Scholar : PubMed/NCBI
19	Eylan E, Zmucky R and Sheba C: Mumps virus and subacute thyroiditis; Evidence of a causal association. Lancet. 272:1062–1063. 1957. View Article : Google Scholar : PubMed/NCBI
20	Felix-Davies D: Autoimmunisation in subacute thyroiditis. Lancet. 1:880–883. 1958. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review

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Abstract

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