Analysis of the first therapeutic-target-achieving time of warfarin therapy and associated factors in patients with pulmonary embolism

  • Authors:
    • Xiaowei Gong
    • Haiyan Wang
    • Yadong Yuan
  • View Affiliations

  • Published online on: August 23, 2016     https://doi.org/10.3892/etm.2016.3610
  • Pages: 2265-2274
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Abstract

The present study aimed to investigate the factors affecting the first therapeutic-target-achieving (TTA) time of warfarin therapy in patients with acute pulmonary embolism (PTE). Between January 2008 and June 2013, patients with PTE confirmed by transpulmonary arterial enhanced computed tomographic pulmonary angiography or pulmonary ventilation perfusion scanning were included in the present study. Data collected included demographic information, history of tobacco and alcohol intake, basic diseases (stable and unstable hypertension, diabetes, heart failure, cancer/cerebral infarction, old myocardial infarction and atrial fibrillation), liver and kidney function, the haemoglobin and platelet count of the blood, international normalized ratio monitoring, warfarin dosage adjustment and medication combinations. Dynamic changes in international normalized ratio, anticoagulant efficacy, and adverse events within 90 days were monitored and analyzed. Univariate analysis demonstrated that the following factors affect the first TTA time: Initial dose, body mass index (BMI), liver function, heart failure, and the administration of levofloxacin, cephalosporins, and blood circulation‑activating drugs. Logistic regression analysis revealed that the following were independent factors of the first TTA time: Initial dose, BMI, liver function, heart failure and levofloxacin. Therefore, the results of the present study demonstrated that various factors may affect the first TTA time of warfarin therapy, including the initial dose, BMI, liver function, heart function and concomitant medication.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gong X, Wang H and Yuan Y: Analysis of the first therapeutic-target-achieving time of warfarin therapy and associated factors in patients with pulmonary embolism. Exp Ther Med 12: 2265-2274, 2016
APA
Gong, X., Wang, H., & Yuan, Y. (2016). Analysis of the first therapeutic-target-achieving time of warfarin therapy and associated factors in patients with pulmonary embolism. Experimental and Therapeutic Medicine, 12, 2265-2274. https://doi.org/10.3892/etm.2016.3610
MLA
Gong, X., Wang, H., Yuan, Y."Analysis of the first therapeutic-target-achieving time of warfarin therapy and associated factors in patients with pulmonary embolism". Experimental and Therapeutic Medicine 12.4 (2016): 2265-2274.
Chicago
Gong, X., Wang, H., Yuan, Y."Analysis of the first therapeutic-target-achieving time of warfarin therapy and associated factors in patients with pulmonary embolism". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2265-2274. https://doi.org/10.3892/etm.2016.3610