Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2016 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2016 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Influencing factors of transient elastography in detecting liver stiffness

Corrigendum in: /10.3892/etm.2018.6864
  • Authors:
    • Rong Shan
    • Hong Yin
    • Wenjuan Yang
    • Jianzhi Li
    • Meifang Zhang
    • Min Zhao
    • Jiang Shao
    • Aiguang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, Shandong University, Jinan, Shandong 250014, P.R. China, Department of Ultrasound, Jinan Maternity and Child Care Hospital, Jinan, Shandong 250000, P.R. China, Department of Emergency, Jinan Center Hospital, Jinan, Shandong 250001, P.R. China, Department of Ultrasound, Jinan Infectious Disease Hospital, Jinan, Shandong 250021, P.R. China, Department of Oncology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 2302-2306
    |
    Published online on: August 24, 2016
       https://doi.org/10.3892/etm.2016.3617
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Liver stiffness, which correlates well with liver fibrosis stage, can be measured noninvasively by transient elastography, also known as Fibroscan. The present study aimed to determine the independent factors influencing Fibroscan detection by multiple regression analysis. A total of 181 patients who required liver biopsy were enrolled. Liver stiffness measurement (LSM) was detected by Fibroscan on the day of liver biopsy, while clinical information and routine biochemical examination results were also collected. Correlation was analyzed by Spearman's correlation, and multiple regression analysis was performed to analyze the independent influencing factors. The results demonstrated that platelet (PLT) levels, serum albumin (ALB), prothrombin activity (PTA) and body mass index (BMI) were independent predictors of liver stiffness. The contribution of these four predictors to the regression equation was in the following descending order: PLT (negative correlation) > ALB (negative correlation) > PTA (negative correlation) > BMI (positive correlation). In conclusion, the parameters of PLT, ALB, PTA and BMI are independent predicting factors affecting Fibroscan detection. Therefore, the diagnosis and evaluation of liver fibrosis should comprehensively consider the results of Fibroscan, and clinical and laboratory examinations.
View Figures
View References

1 

Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, Zhang Y, Liu J, Gong X, Chen Y, et al: Epidemiological serosurvey of hepatitis B in China-declining HBV prevalence due to hepatitis B vaccination. Vaccine. 27:6550–6557. 2009. View Article : Google Scholar : PubMed/NCBI

2 

el-Serag HB: Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 5:87–107. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Wright TL and Lau JY: Clinical aspects of hepatitis B virus infection. Lancet. 342:1340–1344. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Chen J, Eslick GD and Weltman M: Systematic review with meta-analysis: Clinical manifestations and management of autoimmune hepatitis in the elderly. Aliment Pharmacol Ther. 39:117–124. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Aleman S, Rahbin N, Weiland O, Davidsdottir L, Hedenstierna M, Rose N, Verbaan H, Stål P, Carlsson T, Norrgren H, et al: A risk for hepatocellular carcinoma persists long-term after sustained virologic response in patients with hepatitis C-associated liver cirrhosis. Clin Infect Dis. 57:230–236. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Angeli P, Sanyal A, Moller S, Alessandria C, Gadano A, Kim R, Sarin SK and Bernardi M: International Club of Ascites: Current limits and future challenges in the management of renal dysfunction in patients with cirrhosis: Report from the International Club of Ascites. Liver Int. 33:16–23. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Sharara AI, Hunt CM and Hamilton JD: Hepatitis C. Ann Intern Med. 125:658–668. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Masuzaki R, Tateishi R, Yoshida H, Goto E, Sato T, Ohki T, Imamura J, Goto T, Kanai F, Kato N, et al: Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography. Hepatology. 49:1954–1961. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Castéra L, Vergniol J, Foucher J, Le Bail B, Chanteloup E, Haaser M, Darriet M, Couzigou P and De Lédinghen V: Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology. 128:343–350. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Colletta C, Smirne C, Fabris C, Toniutto P, Rapetti R, Minisini R and Pirisi M: Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases. Hepatology. 42:838–845. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Degos F, Perez P, Roche B, Mahmoudi A, Asselineau J, Voitot H and Bedossa P: FIBROSTIC study group: Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: A multicenter prospective study (the FIBROSTIC study). J Hepatol. 53:1013–1021. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Sebastiani G, Halfon P, Castera L, Pol S, Thomas DL, Mangia A, Di Marco V, Pirisi M, Voiculescu M, Guido M, et al: SAFE biopsy: A validated method for large-scale staging of liver fibrosis in chronic hepatitis C. Hepatology. 49:1821–1827. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Bonder A and Afdhal NH: Biopsy no more; changing the screening and diagnostic algorithm for hepatitis C. Clin Gastroenterol Hepatol. 11:309–310. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Foucher J, Chanteloup E, Vergniol J, Castéra L, Le Bail B, Adhoute X, Bertet J, Couzigou P and de Lédinghen V: Diagnosis of cirrhosis by transient elastography (FibroScan): A prospective study. Gut. 55:403–408. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Nguyen-Khac E, Chatelain D, Tramier B, Decrombecque C, Robert B, Joly JP, Brevet M, Grignon P, Lion S, Le Page L and Dupas JL: Assessment of asymptomatic liver fibrosis in alcoholic patients using Fibroscan: Prospective comparison with seven non-invasive laboratory tests. Aliment Pharmacol Ther. 28:1188–1198. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Mueller S, Millonig G, Sarovska L, Friedrich S, Reimann FM, Pritsch M, Eisele S, Stickel F, Longerich T, Schirmacher P and Seitz HK: Increased liver stiffness in alcoholic liver disease: Differentiating fibrosis from steatohepatitis. World J Gastroenterol. 16:966–972. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Obara N, Ueno Y, Fukushima K, Nakagome Y, Kakazu E, Kimura O, Wakui Y, Kido O, Ninomiya M, Kogure T, et al: Transient elastography for measurement of liver stiffness measurement can detect early significant hepatic fibrosis in Japanese patients with viral and nonviral liver diseases. J Gastroenterol. 43:720–728. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Vergniol J, Foucher J, Mamou K, Castéra L, Bernard PH, Couzigou P and de Lédinghen V: Non-invasive evaluation of liver fibrosis using FibroScan in long-term sustained-virological responder patients after HCV treatment. Gastroenterol Clin Biol. 32:1061–1063. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Wang JH, Changchien CS, Hung CH, Tung WC, Kee KM, Chen CH, Hu TH, Lee CM and Lu SN: Liver stiffness decrease after effective antiviral therapy in patients with chronic hepatitis C: Longitudinal study using FibroScan. J Gastroenterol Hepatol. 25:964–969. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Marcellin P, Ziol M, Bedossa P, Douvin C, Poupon R, de Lédinghen V and Beaugrand M: Non-invasive assessment of liver fibrosis by stiffiness measurement in patients with chronic hepatitis B. Liver Int. 29:242–247. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Tsochatzis EA, Gurosamy KS, Ntaoula S, Cholongitas E, Davidson BR and Burroughs AK: Elastography for the diagnosis of severity of fibrosis in chronic liver disease: A meta-analysis of diagnostic accuracy. J Hepatol. 54:650–659. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Sagir A, Erhardt A, Schmitt M and Häussinger D: Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage. Hepatology. 47:592–595. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Fildes R: Conditioning diagnostics: Collinearity and weak data in regression. Technometrics. 35:85–86. 1993. View Article : Google Scholar

24 

Tana MM, Zhao X, Bradshaw A, Moon MS, Page S, Turner T, Rivera E, Kleiner DE and Heller T: Factors associated with the platelet count in patients with chronic hepatitis C. Thromb Res. 135:823–828. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Lu SN, Wang JH, Liu SL, Hung CH, Chen CH, Tung HD, Chen TM, Huang WS, Lee CM, Chen CC and Changchien CS: Thrombocytopenia as a surrogate for cirrhosis and a marker for the identification of patients at high-risk for hepatocellular carcinoma. Cancer. 107:2212–2222. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Henderson NC and Iredalc JP: Liver fibrosis: Cellular machanisms of progression and resolution. Clin Sci (Lond). 112:265–280. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Cournane S, Browne JE and Fagan AJ: The effects of fatty deposits on the accuracy of the Fibroscan® liver transient elastography ultrasound system. Phys Med Biol. 57:3901–3914. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Tapper EB, Cohen EB, Patel K, Bacon B, Gordon S, Lawitz E, Nelson D, Nasser IA, Challies T and Afdhal N: Levels of alanine aminotransferase confound use of transient elastography to diagnose fibrosis in patients with chronic hepatitis C virus infection. Clin Gastroenterol Heaptol. 10:932–937.e1. 2012. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shan R, Yin H, Yang W, Li J, Zhang M, Zhao M, Shao J and Wang A: Influencing factors of transient elastography in detecting liver stiffness Corrigendum in /10.3892/etm.2018.6864 . Exp Ther Med 12: 2302-2306, 2016.
APA
Shan, R., Yin, H., Yang, W., Li, J., Zhang, M., Zhao, M. ... Wang, A. (2016). Influencing factors of transient elastography in detecting liver stiffness Corrigendum in /10.3892/etm.2018.6864 . Experimental and Therapeutic Medicine, 12, 2302-2306. https://doi.org/10.3892/etm.2016.3617
MLA
Shan, R., Yin, H., Yang, W., Li, J., Zhang, M., Zhao, M., Shao, J., Wang, A."Influencing factors of transient elastography in detecting liver stiffness Corrigendum in /10.3892/etm.2018.6864 ". Experimental and Therapeutic Medicine 12.4 (2016): 2302-2306.
Chicago
Shan, R., Yin, H., Yang, W., Li, J., Zhang, M., Zhao, M., Shao, J., Wang, A."Influencing factors of transient elastography in detecting liver stiffness Corrigendum in /10.3892/etm.2018.6864 ". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2302-2306. https://doi.org/10.3892/etm.2016.3617
Copy and paste a formatted citation
x
Spandidos Publications style
Shan R, Yin H, Yang W, Li J, Zhang M, Zhao M, Shao J and Wang A: Influencing factors of transient elastography in detecting liver stiffness Corrigendum in /10.3892/etm.2018.6864 . Exp Ther Med 12: 2302-2306, 2016.
APA
Shan, R., Yin, H., Yang, W., Li, J., Zhang, M., Zhao, M. ... Wang, A. (2016). Influencing factors of transient elastography in detecting liver stiffness Corrigendum in /10.3892/etm.2018.6864 . Experimental and Therapeutic Medicine, 12, 2302-2306. https://doi.org/10.3892/etm.2016.3617
MLA
Shan, R., Yin, H., Yang, W., Li, J., Zhang, M., Zhao, M., Shao, J., Wang, A."Influencing factors of transient elastography in detecting liver stiffness Corrigendum in /10.3892/etm.2018.6864 ". Experimental and Therapeutic Medicine 12.4 (2016): 2302-2306.
Chicago
Shan, R., Yin, H., Yang, W., Li, J., Zhang, M., Zhao, M., Shao, J., Wang, A."Influencing factors of transient elastography in detecting liver stiffness Corrigendum in /10.3892/etm.2018.6864 ". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2302-2306. https://doi.org/10.3892/etm.2016.3617
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team