Influence of random urine albumin-creatinine ratio of pregnant women with hypertension during the gestation period on perinatal outcome

Yan,Qian; Wang,Hongmei; Liu,Ronghui; Jiang,Ling; Liu,Jingying; Wang,Lijuan; Guo,Yuanying

doi:10.3892/etm.2016.3620

Influence of random urine albumin-creatinine ratio of pregnant women with hypertension during the gestation period on perinatal outcome

Authors:
- Qian Yan
- Hongmei Wang
- Ronghui Liu
- Ling Jiang
- Jingying Liu
- Lijuan Wang
- Yuanying Guo
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Affiliations: Department of Obstetrics and Gynecology, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China, Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Jinan, Shandong 250021, P.R. China, Department of Obstetrics and Gynecology, Zhaoyuan People's Hospital, Zhaoyuan, Shandong 265400, P.R. China, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China
Published online on: August 25, 2016 https://doi.org/10.3892/etm.2016.3620
Pages: 2521-2526
Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the influence of the random urine albumin-creatinine ratio (ACR) of pregnant women with hypertension during the gestation period on perinatal outcome. A total of 6,758 pregnant women with pregnancy-induced hypertension and proteinuria were randomly selected between September, 2009 and June, 2015 for the study. Kidney function, blood pressure, history of gravidity and parity, embryo number and the birth weight of the participants was determined. Logistic regression and paired data correlation analyses were carried out with kidney function, blood pressure, history of gravidity and parity, embryo number, birth weight, maternal age, labor presentation and other risk factors as the independent variables and the newborn APGAR score as the dependent variable. The results showed that random urine ACR was increased and negatively correlated with the APGAR score (OR=‑0.095, P=0.017). In conclusion, the increased random urine ACR can influence the postpartum outcome. Early intervention of women of childbearing age in early pregnancy or before pregnancy can minimize the adverse complications of infants and mothers such as pregnancy hypertension syndrome, and improve the outcome of the pregnancy.

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