Open Access

Use of deep brain stimulation for major affective disorders (Review)

  • Authors:
    • Kuanqing Mi
  • View Affiliations

  • Published online on: August 25, 2016     https://doi.org/10.3892/etm.2016.3622
  • Pages: 2371-2376
  • Copyright: © Mi . This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The multifactorial etiology of major affective disorders, such as major depression and bipolar disorder, poses a challenge for identification of effective treatments. In a substantial number of patients, psychopharmacologic treatment does not lead to effective continuous symptom relief. The use of deep brain stimulation (DBS) for treatment-resistant patients is an investigational approach that has recently produced promising results. The recent development of safer stereotaxic neurosurgery, and the combination with functional neuroimaging to map the affected brain circuits, have led to the investigation of DBS as a potential strategy to treat major mood disorders. Several independent clinical studies have recently shown that chronic DBS treatment leads to remission of symptoms in a high number of treatment-resistant patients for major depression and bipolar disorder. In conclusion, the existing proof-of-principle that DBS can be an effective intervention for treatment-resistant depression opens new avenues for treatment. However, multicenter, randomized and blind trials need to confirm efficacy and be approved after the most recent failures. Patient selection and surgical-related improvements are key issues that remain to be addressed to help deliver more precise and customized treatment.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Mi K: Use of deep brain stimulation for major affective disorders (Review). Exp Ther Med 12: 2371-2376, 2016
APA
Mi, K. (2016). Use of deep brain stimulation for major affective disorders (Review). Experimental and Therapeutic Medicine, 12, 2371-2376. https://doi.org/10.3892/etm.2016.3622
MLA
Mi, K."Use of deep brain stimulation for major affective disorders (Review)". Experimental and Therapeutic Medicine 12.4 (2016): 2371-2376.
Chicago
Mi, K."Use of deep brain stimulation for major affective disorders (Review)". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2371-2376. https://doi.org/10.3892/etm.2016.3622