Open Access

Clinical characteristics of drug-induced liver injury and related risk factors

  • Authors:
    • Ren‑Jie Lu
    • Yan Zhang
    • Feng‑Lei Tang
    • Zhong‑Wei Zheng
    • Zheng‑Da Fan
    • Shan‑Mei Zhu
    • Xian‑Feng Qian
    • Na‑Na Liu
  • View Affiliations

  • Published online on: August 29, 2016     https://doi.org/10.3892/etm.2016.3627
  • Pages: 2606-2616
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Drug-induced liver injury (DILI) is often undiagnosed or misdiagnosed clinically because of diagnostic difficulties caused by lack of laboratory-specific serological markers. In this study, we comprehensively assessed the clinical characteristics, laboratory indices, hepatotoxic drugs, risk factors and outcomes concerning DILI, and explored the similarities in mechanisms between Chinese and Western drug‑induced DILI. Patients with a first diagnosis of DILI and a Roussel Uclaf Causality Assessment Method (RUCAM) score >3 points were enrolled for systematic retrospective study. Their clinical characteristics, clinical classification, risk factors, laboratory indices, hepatotoxic drugs and outcomes were analyzed. Cholestatic patients had the highest alkaline phosphatase (ALP) and prothrombin time activity (PTA) levels (P<0.05). Patients with medication time ≥30 days had significantly higher positive rate of autoantibodies than those with medication time <30 days. Odds ratio values for DILI‑related factors such as hepatobiliary diseases, immune dysfunction, diabetes, hypertension, chronic alcohol consumption and age ≥45 years were 6.552, 6.130, 3.774, 2.801, 2.002 and 1.838, respectively. Pathogeneses of Chinese and Western drug‑induced DILI may be substantially the same. DILI accompanied with autoantibody positivity may indicate severe liver injury outcome. Hepatobiliary diseases, diabetes and hypertension are likely to increase drug susceptibility, and more prone to cause liver injury.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lu RJ, Zhang Y, Tang FL, Zheng ZW, Fan ZD, Zhu SM, Qian XF and Liu NN: Clinical characteristics of drug-induced liver injury and related risk factors. Exp Ther Med 12: 2606-2616, 2016
APA
Lu, R., Zhang, Y., Tang, F., Zheng, Z., Fan, Z., Zhu, S. ... Liu, N. (2016). Clinical characteristics of drug-induced liver injury and related risk factors. Experimental and Therapeutic Medicine, 12, 2606-2616. https://doi.org/10.3892/etm.2016.3627
MLA
Lu, R., Zhang, Y., Tang, F., Zheng, Z., Fan, Z., Zhu, S., Qian, X., Liu, N."Clinical characteristics of drug-induced liver injury and related risk factors". Experimental and Therapeutic Medicine 12.4 (2016): 2606-2616.
Chicago
Lu, R., Zhang, Y., Tang, F., Zheng, Z., Fan, Z., Zhu, S., Qian, X., Liu, N."Clinical characteristics of drug-induced liver injury and related risk factors". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2606-2616. https://doi.org/10.3892/etm.2016.3627