Part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration in the treatment of severe acute liver failure

Li,Maoqin; Wang,Zhidong; Wang,Yining; Du,Changhong; Li,Songhai; Shi,Zaixiang; Lu,Bo

doi:10.3892/etm.2016.3633

October-2016 Volume 12 Issue 4

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October-2016 Volume 12 Issue 4

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Article Open Access

Part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration in the treatment of severe acute liver failure

Authors:
- Maoqin Li
- Zhidong Wang
- Yining Wang
- Changhong Du
- Songhai Li
- Zaixiang Shi
- Bo Lu
View Affiliations / Copyright

Affiliations: Department of Intensive Care Unit, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China

Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2582-2584
|
Published online on: August 30, 2016

https://doi.org/10.3892/etm.2016.3633
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Abstract

The present study is a retrospective analysis of 11 cases with severe acute liver failure combined with multiple organ dysfunction syndrome (MODS) performed during the period June, 2012 to December, 2014. After part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration treatment, good curative effects were obtained and the main clinical symptoms and biochemical index were significantly improved. Following treatment, 8 of the 11 patients survived at a survival rate of 72.7%, and 3 patients succumbed with a mortality of 27.3%. The results suggested that part of plasmapheresis with plasma filtration adsorption combined with continuous venovenous hemodiafiltration (CVVHDF) treatment is beneficial in the removal of metabolites and toxins. Additonally, it can effectively improve liver function and clinical symptoms, improve hepatic encephalopathy, correct the disorder of internal environment, and improve the prognosis of patients.

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1	Li LJ, Zhang YM, Liu XL, Du WB, Huang JR, Yang Q, Xu XW and Chen YM: Artificial liver support system in China: A review over the last 30 years. Ther Apher Dial. 10:160–167. 2006. View Article : Google Scholar : PubMed/NCBI
2	Nevens F and Laleman W: Artificial liver support devices as treatment option for liver failure. Best Pract Res Clin Gastroenterol. 26:17–26. 2012. View Article : Google Scholar : PubMed/NCBI
3	Lee WM, Squires RJ, Nyberg SL, Doo E and Hoofnagle JH: Acute liver failure: Summary of a workshop. Hepatology. 47:1401–1415. 2008. View Article : Google Scholar : PubMed/NCBI
4	Freeman JG, Matthewson K and Record CO: Plasmapheresis in acute liver failure. Int J Artif Organs. 9:433–438. 1986.PubMed/NCBI
5	Sentürk E, Esen F, Ozcan PE, Rifai K, Pinarbaşi B, Cakar N and Telci L: The treatment of acute liver failure with fractionated plasma separation and adsorption system: experience in 85 applications. J Clin Apher. 25:195–201. 2010. View Article : Google Scholar : PubMed/NCBI
6	He CS, Shi W, Ye ZM, Liang XL, Zhang B, Liu SX and Qin TH: Experiment and clinical research of coupled plasma filtration adsorption with hemofiltration on the treatment of multiple organ dysfunction syndrome. Chin Crit Care Med. 19:47–49. 2007.(In Chinese).
7	Liu Y, He JQ, Che DP and Yang WL: Treatment of artificial liver support system on acute liver failure combined with multiple organ dysfunction syndyrome. Chin Crit Care Med. 18:431–432. 2006.(In Chinese).
8	Yin G, Ya C, Li Q, et al: Clinical research of DPMAS treatment on liver failure by the combination of two blood perfusion machines. Chin J Crit Care Med. 25:738–742. 2013.(In Chinese).
9	Liver Failure; Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association, Severe Liver Diseases and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association, : Diagnostic and treatment guidelines for liver failure. Zhonghua Gan Zang Bing Za Zhi. 14:643–646. 2006.PubMed/NCBI
10	Morgan SM and Zantek ND: Therapeutic plasma exchange for fulminant hepatic failure secondary to Wilson's disease. J Clin Apher. 27:282–286. 2012. View Article : Google Scholar : PubMed/NCBI
11	Weston MJ: Charcoal hemoperfusion for liver failure. Lancet. 2:9831982. View Article : Google Scholar : PubMed/NCBI
12	Chen J, Han W, Su R, Chen J, Zong W, Wang Y, Wang W, Cheng G, Ou L and Yu Y: Non-ionic macroporous polystyrene adsorbents for removal of serum toxins in liver failure by hemoperfusion. Artif Cells Nanomed Biotechnol. Feb 2–2016.(Epub ahead of print). View Article : Google Scholar
13	Ryska O, Pantoflicek T, Laszikova E, Prazak J, Koblihova E and Ryska M: Artificial liver support system reduces intracranial pressure more effectively than bioartificial system: An experimental study. Int J Artif Organs. 35:503–510. 2012. View Article : Google Scholar
14	Stutchfield BM, Simpson K and Wigmore SJ: Systematic review and meta-analysis of survival following extracorporeal liver support. Br J Surg. 98:623–631. 2011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration in the treatment of severe acute liver failure

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