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Local application of low-dose insulin in improving wound healing after deep burn surgery

  • Authors:
    • Chejiang Wang
    • Jiazhe Wang
    • Jianke Feng
  • View Affiliations / Copyright

    Affiliations: Department of Burn and Plastic Surgery, The First Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Burn and Plastic Surgery, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2527-2530
    |
    Published online on: September 1, 2016
       https://doi.org/10.3892/etm.2016.3645
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Abstract

The clinical effects of local application of low‑dose insulin in improving wound healing after deep burn self-skin transplantation surgery were examined. Fifty-eight patients with deep burns were selected and randomly divided into 3 groups. In the blank control group, normal saline was injected to the subcutaneous tissue of wounds; in large dose insulin group, 1.0 µ long-term suspended zinc insulin was locally injected; and in the low-dose insulin group, 0.1 µ long‑term suspended zinc insulin was locally injected. The healing effects were compared. After 7 and 14 days of treatments, wound surface area in the low‑dose group was significantly smaller than in the other groups, and differences were statistically significant (P<0.05); wound healing duration and infection rate for patients in the low‑dose group were significantly lower, class A healing rate was significantly improved, and the differences were statistically significant (P<0.05). Insulin resistance index (HOMA-IR) in the low-dose group was significantly lower, insulin secretion index (HOMA-β) and the insulin sensitivity index (HOMA-ISI) significantly increased. The expression levels of vascular endothelial growth factor and tumor necrosis factor-α in local tissue for the low-dose group were significantly higher than those in the other two groups. Differences were statistically significant (P<0.05). In conclusion, local application of low‑dose insulin can effectively improve wound healing after deep burn surgeries.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Wang J and Feng J: Local application of low-dose insulin in improving wound healing after deep burn surgery. Exp Ther Med 12: 2527-2530, 2016.
APA
Wang, C., Wang, J., & Feng, J. (2016). Local application of low-dose insulin in improving wound healing after deep burn surgery. Experimental and Therapeutic Medicine, 12, 2527-2530. https://doi.org/10.3892/etm.2016.3645
MLA
Wang, C., Wang, J., Feng, J."Local application of low-dose insulin in improving wound healing after deep burn surgery". Experimental and Therapeutic Medicine 12.4 (2016): 2527-2530.
Chicago
Wang, C., Wang, J., Feng, J."Local application of low-dose insulin in improving wound healing after deep burn surgery". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2527-2530. https://doi.org/10.3892/etm.2016.3645
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Wang J and Feng J: Local application of low-dose insulin in improving wound healing after deep burn surgery. Exp Ther Med 12: 2527-2530, 2016.
APA
Wang, C., Wang, J., & Feng, J. (2016). Local application of low-dose insulin in improving wound healing after deep burn surgery. Experimental and Therapeutic Medicine, 12, 2527-2530. https://doi.org/10.3892/etm.2016.3645
MLA
Wang, C., Wang, J., Feng, J."Local application of low-dose insulin in improving wound healing after deep burn surgery". Experimental and Therapeutic Medicine 12.4 (2016): 2527-2530.
Chicago
Wang, C., Wang, J., Feng, J."Local application of low-dose insulin in improving wound healing after deep burn surgery". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2527-2530. https://doi.org/10.3892/etm.2016.3645
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