Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2016 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2016 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure

  • Authors:
    • Xiaojian Zhang
    • Chengwu Shen
    • Shujun Zhai
    • Yukun Liu
    • Wen‑Wei Yue
    • Li Han
  • View Affiliations / Copyright

    Affiliations: Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan, Shandong 250021, P.R. China, Laiwu Health School, Laiwu, Shandong 271100, P.R. China, The Fourth People's Hospital of Ji'nan, Ji'nan, Shandong 250021, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2489-2496
    |
    Published online on: September 5, 2016
       https://doi.org/10.3892/etm.2016.3657
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Adrenergic β‑blockers are drugs that bind to, but do not activate β‑adrenergic receptors. Instead they block the actions of β-adrenergic agonists and are used for the treatment of various diseases such as cardiac arrhythmias, angina pectoris, myocardial infarction, hypertension, headache, migraines, stress, anxiety, prostate cancer, and heart failure. Several meta‑analysis studies have shown that β‑blockers improve the heart function and reduce the risks of cardiovascular events, rate of mortality, and sudden death through chronic heart failure (CHF) of patients. The present study identified results from recent meta‑analyses of β‑adrenergic blockers and their usefulness in CHF. Databases including Medline/Embase/Cochrane Central Register of Controlled Trials (CENTRAL), and PubMed were searched for the periods May, 1985 to March, 2011 and June, 2013 to August, 2015, and a number of studies identified. Results of those studies showed that use of β‑blockers was associated with decreased sudden cardiac death in patients with heart failure. However, contradictory results have also been reported. The present meta‑analysis aimed to determine the efficacy of β‑blockers on mortality and morbidity in patients with heart failure. The results showed that mortality was significantly reduced by β‑blocker treatment prior to the surgery of heart failure patients. The results from the meta‑analysis studies showed that β‑blocker treatment in heart failure patients correlated with a significant decrease in long‑term mortality, even in patients that meet one or more exclusion criteria of the MERIT‑HF study. In summary, the findings of the current meta-analysis revealed beneficial effects different β‑blockers have on patients with heart failure or related heart disease.
View Figures
View References

1 

Lechat P, Packer M, Chalon S, Cucherat M, Arab T and Boissel JP: Clinical effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomized trials. Circulation. 98:1184–1191. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Packer M: The neurohormonal hypothesis: A theory to explain the mechanism of disease progression in heart failure. J Am Coll Cardiol. 20:248–254. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Doughty RN, Rodgers A, Sharpe N and MacMahon S: Effects of beta-blocker therapy on mortality in patients with heart failure: A systematic overview of randomized controlled trials. Eur Heart J. 18:560–565. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Heidenreich PA, Lee TT and Massie BM: Effect of beta-blockade on mortality in patients with heart failure: a meta-analysis of randomized clinical trials. J Am Coll Cardiol. 30:27–34. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Al-Gobari M, El Khatib C, Pillon F and Gueyffier F: β-Blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 13:522013. View Article : Google Scholar : PubMed/NCBI

6 

DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI

7 

Higgins JPT, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Anderson JL, Lutz JR, Gilbert EM, Sorensen SG, Yanowitz FG, Menlove RL and Bartholomew M: A randomized trial of low-dose beta-blockade therapy for idiopathic dilated cardiomyopathy. Am J Cardiol. 55:471–475. 1985. View Article : Google Scholar : PubMed/NCBI

9 

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ and McQuay HJ: Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 17:1–12. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Piccini JP, Berger JS and O'Connor CM: Amiodarone for the prevention of sudden cardiac death: A meta-analysis of randomized controlled trials. Eur Heart J. 30:1245–1253. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Beta-Blocker Evaluation of Survival Trial Investigators: A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure. N Engl J Med. 344:1659–1667. 2001. View Article : Google Scholar : PubMed/NCBI

12 

No authors listed: Randomised, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease. Australia/New Zealand Heart Failure Research Collaborative Group. Lancet. 349:375–380. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Chadda K, Goldstein S, Byington R and Curb JD: Effect of propranolol after acute myocardial infarction in patients with congestive heart failure. Circulation. 73:503–510. 1986. View Article : Google Scholar : PubMed/NCBI

14 

Bristow MR, O'Connell JB, Gilbert EM, French WJ, Leatherman G, Kantrowitz NE, Orie J, Smucker ML, Marshall G and Kelly P: Bucindolol Investigators: Dose-response of chronic beta-blocker treatment in heart failure from either idiopathic dilated or ischemic cardiomyopathy. Bucindolol Investigators. Circulation. 89:1632–1642. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Bristow MR, Gilbert EM, Abraham WT, Adams KF, Fowler MB, Hershberger RE, Kubo SH, Narahara KA, Ingersoll H, Krueger S, et al: Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators. Circulation. 94:2807–2816. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Dargie HJ: Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. Lancet. 357:1385–1390. 2001. View Article : Google Scholar : PubMed/NCBI

17 

No authors listed: The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): A randomized trial. Lancet. 353:9–13. 1999. View Article : Google Scholar : PubMed/NCBI

18 

No authors listed: A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees. Circulation. 90:1765–1773. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Witchitz S, Cohen-Solal A, Dartois N, Weisslinger N, Juste K and Darmon JY: Treatment of heart failure with celiprolol, a cardioselective beta blocker with beta-2 agonist vasodilatory properties. The CELICARD Group. Am J Cardiol. 85:1467–1471. 2000. View Article : Google Scholar

20 

Colucci WS, Packer M, Bristow MR, Gilbert EM, Cohn JN, Fowler MB, Krueger SK, Hershberger R, Uretsky BF, Bowers JA, et al: Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure. US Carvedilol Heart Failure Study Group. Circulation. 94:2800–2806. 1996.

21 

Packer M, Fowler MB, Roecker EB, Coats AJS, Katus HA, Krum H, Mohacsi P, Rouleau JL, Tendera M, Staiger C, et al: Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study Group: Effect of carvedilol on the morbidity of patients with severe chronic heart failure: Results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation. 106:2194–2199. 2002. View Article : Google Scholar : PubMed/NCBI

22 

de Milliano PA, de Groot AC, Tijssen JG, van Eck-Smit BL, Van Zwieten PA and Lie KI: Beneficial effects of metoprolol on myocardial sympathetic function: Evidence from a randomized, placebo-controlled study in patients with congestive heart failure. Am Heart J. 144:E32002. View Article : Google Scholar : PubMed/NCBI

23 

Conraads VM, Metra M, Kamp O, De Keulenaer GW, Pieske B, Zamorano J, Vardas PE, Böhm M and Dei Cas L: Effects of the long-term administration of nebivolol on the clinical symptoms, exercise capacity, and left ventricular function of patients with diastolic dysfunction: results of the ELANDD study. Eur J Heart Fail. 14:219–225. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Engelmeier RS, O'Connell JB, Walsh R, Rad N, Scanlon PJ and Gunnar RM: Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: A double-blind, randomized, placebo-controlled trial. Circulation. 72:536–546. 1985. View Article : Google Scholar : PubMed/NCBI

25 

Fisher ML, Gottlieb SS, Plotnick GD, Greenberg NL, Patten RD, Bennett SK and Hamilton BP: Beneficial effects of metoprolol in heart failure associated with coronary artery disease: A randomized trial. J Am Coll Cardiol. 23:943–950. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Hansteen V, Møinichen E, Lorentsen E, Andersen A, Strøm O, Søiland K, Dyrbekk D, Refsum AM, Tromsdal A, Knudsen K, et al: One year's treatment with propranolol after myocardial infarction: Preliminary report of Norwegian multicentre trial. Br Med J (Clin Res Ed). 284:155–160. 1982. View Article : Google Scholar : PubMed/NCBI

27 

Krum H, Sackner-Bernstein JD, Goldsmith RL, Kukin ML, Schwartz B, Penn J, Medina N, Yushak M, Horn E, Katz SD, et al: Double-blind, placebo-controlled study of the long-term efficacy of carvedilol in patients with severe chronic heart failure. Circulation. 92:1499–1506. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Waagstein F, Bristow MR, Swedberg K, Camerini F, Fowler MB, Silver MA, Gilbert EM, Johnson MR, Goss FG and Hjalmarson A: Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group. Lancet. 342:1441–1446. 1993.

29 

No authors listed: Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet. 353:2001–2007. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Metra M, Nardi M, Giubbini R and Dei Cas L: Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 24:1678–1687. 1994. View Article : Google Scholar : PubMed/NCBI

31 

Olsen SL, Gilbert EM, Renlund DG, Taylor DO, Yanowitz FD and Bristow MR: Carvedilol improves left ventricular function and symptoms in chronic heart failure: A double-blind randomized study. J Am Coll Cardiol. 25:1225–1231. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM and Shusterman NH: The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carve-dilol Heart Failure Study Group. N Engl J Med. 334:1349–1355. 1996.

33 

Pollock SG, Lystash J, Tedesco C, Craddock G and Smucker ML: Usefulness of bucindolol in congestive heart failure. Am J Cardiol. 66:603–607. 1990. View Article : Google Scholar : PubMed/NCBI

34 

No authors listed: Effects of metoprolol CR in patients with ischemic and dilated cardiomyopathy: the randomized evaluation of strategies of left ventricular dysfunction pilot study. Circulation. 101:378–384. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Flather MD, Shibata MC, Coats AJS, van Veldhuisen DJ, Parkhomenko A, Borbola J, Cohen-Solal A, Dumitrascu D, Ferrari R, Lechat P, et al: Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J. 26:215–225. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Sturm B, Pacher R, Strametz-Juranek J, Berger R, Frey B and Stanek B: Effect of beta 1 blockade with atenolol on progression of heart failure in patients pretreated with high-dose enalapril. Eur J Heart Fail. 2:407–412. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Uhlir O, Dvorak I, Gregor P, Malek I, Spinarova L, Vojacek J and Van Nueten L: Nebivolol in the treatment of cardiac failure: A double-blind controlled clinical trial. J Card Fail. 3:271–276. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Wisenbaugh T, Katz I, Davis J, Essop R, Skoularigis J, Middlemost S, Röthlisberger C, Skudicky D and Sareli P: Long-term (3-month) effects of a new beta-blocker (nebivolol) on cardiac performance in dilated cardiomyopathy. J Am Coll Cardiol. 21:1094–1100. 1993. View Article : Google Scholar : PubMed/NCBI

39 

Woodley SL, Gilbert EM, Anderson JL, O'Connell JB, Deitchman D, Yanowitz FG, Mealey PC, Volkman K, Renlund DG and Menlove R: Beta-blockade with bucindolol in heart failure caused by ischemic versus idiopathic dilated cardiomyopathy. Circulation. 84:2426–2441. 1991. View Article : Google Scholar : PubMed/NCBI

40 

Bonet S, Agusti A, Arnau JM, Vidal X, Diogène E, Galve E and Laporte JR: Beta-adrenergic blocking agents in heart failure: benefits of vasodilating and non-vasodilating agents according to patients' characteristics: a meta-analysis of clinical trials. Arch Intern Med. 160:621–627. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Hanania NA, Singh S, El-Wali R, Flashner M, Franklin AE, Garner WJ, Dickey BF, Parra S, Ruoss S, Shardonofsky F, et al: The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study. Pulm Pharmacol Ther. 21:134–141. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Larochelle P, Tobe SW and Lacourcière Y: β-Blockers in Hypertension: studies and meta-analyses over the years. Can J Cardiol. 30 Suppl 5:S16–S22. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Matowa PR: Beta Blockers Use in Cardiac Failure: Does the Current Prescribing Practice at a Large Urban Hospital in Zimbabwe Exhibit Evidence Based Care and Offer Optimal Therapy for Cardiac Failure Patients? Pharmacology & Pharmacy. 6:267–279. 2015. View Article : Google Scholar

44 

Bangalore S, Makani H, Radford M, Thakur K, Toklu B, Katz SD, DiNicolantonio JJ, Devereaux PJ, Alexander KP, Wetterslev J and Messerli FH: Clinical outcomes with β-blockers for myocardial infarction: a meta-analysis of randomized trials. Am J Med. 127:939–953. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Bavishi C, Chatterjee S, Ather S, Patel D and Messerli FH: Beta-blockers in heart failure with preserved ejection fraction: A meta-analysis. Heart Fail Rev. 20:193–201. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Lu H, Liu X, Guo F, Tan S, Wang G, Liu H, Wang J, He X, Mo Y and Shi B: Impact of beta-blockers on prostate cancer mortality: a meta-analysis of 16,825 patients. Onco Targets Ther. 8:985–990. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Andrews TC, Reimold SC, Berlin JA and Antman EM: Prevention of supraventricular arrhythmias after coronary artery bypass surgery. A meta-analysis of randomized control trials. Circulation. 84 Suppl 5:III236–III244. 1991.

48 

Chatterjee S, Biondi-Zoccai G, Abbate A, D'Ascenzo F, Castagno D, van Tassell B, Mukherjee D and Lichstein E: Benefits of β blockers in patients with heart failure and reduced ejection fraction: network meta-analysis. BMJ. 346:f552013. View Article : Google Scholar : PubMed/NCBI

49 

Ma ST, Zhao W, Liu B, Jia RY, Zhao CJ and Cui LQ: Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis. Genet Mol Res. 14:5922–5929. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Mostafaie K, Bedenis R and Harrington D: Beta-adrenergic blockers for perioperative cardiac risk reduction in people undergoing vascular surgery. Cochrane Database Syst Rev. 1:CD0063422015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Shen C, Zhai S, Liu Y, Yue WW and Han L: A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure. Exp Ther Med 12: 2489-2496, 2016.
APA
Zhang, X., Shen, C., Zhai, S., Liu, Y., Yue, W., & Han, L. (2016). A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure. Experimental and Therapeutic Medicine, 12, 2489-2496. https://doi.org/10.3892/etm.2016.3657
MLA
Zhang, X., Shen, C., Zhai, S., Liu, Y., Yue, W., Han, L."A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure". Experimental and Therapeutic Medicine 12.4 (2016): 2489-2496.
Chicago
Zhang, X., Shen, C., Zhai, S., Liu, Y., Yue, W., Han, L."A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2489-2496. https://doi.org/10.3892/etm.2016.3657
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Shen C, Zhai S, Liu Y, Yue WW and Han L: A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure. Exp Ther Med 12: 2489-2496, 2016.
APA
Zhang, X., Shen, C., Zhai, S., Liu, Y., Yue, W., & Han, L. (2016). A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure. Experimental and Therapeutic Medicine, 12, 2489-2496. https://doi.org/10.3892/etm.2016.3657
MLA
Zhang, X., Shen, C., Zhai, S., Liu, Y., Yue, W., Han, L."A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure". Experimental and Therapeutic Medicine 12.4 (2016): 2489-2496.
Chicago
Zhang, X., Shen, C., Zhai, S., Liu, Y., Yue, W., Han, L."A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2489-2496. https://doi.org/10.3892/etm.2016.3657
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team