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Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats

  • Authors:
    • Alisa P. Domnina
    • Polina V. Novikova
    • Olga G. Lyublinskaya
    • Valeriy V. Zenin
    • Irina I. Fridlyanskaya
    • Vyacheslav M. Mikhailov
    • Nikolay N. Nikolsky
  • View Affiliations / Copyright

    Affiliations: Department of Intracellular Signaling and Transport, Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia, Department of Obstetrics, Gynecology and Reproductology, Faculty of Medicine, Saint‑Petersburg State University, 199034 Saint Petersburg, Russia
    Copyright: © Domnina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2447-2454
    |
    Published online on: September 6, 2016
       https://doi.org/10.3892/etm.2016.3671
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Abstract

Stem cell transplantation, which is based on the application of mesenchymal stem/stromal cells (MSCs), is a rapidly developing approach to the regenerative therapy of various degenerative disorders characterized by brain and heart failure, as well as skin lesions. In comparison, the use of stem cell transplantations to treat infertility has received less attention. One of the causes of miscarriages and fetal growth delay is the loss of the decidual reaction of endometrial cells. The present study modeled decidualization processes in pseudopregnant rats. For cell transplantation experiments, the rats were transplanted with MSCs established from endometrial fragments in menstrual blood (eMSCs). These cells express common MSC markers, are multipotent and are able to differentiate into various tissue lineages. Cell therapy frequently requires substantial cell biomass, and cultivation of MSCs may be accompanied by significant changes to their properties, including malignant transformation. In order to minimize the potential for malignant transformation, the proliferation of eMSCs was irreversibly suppressed by irradiation and mitomycin C treatment. Transplantation of the rats with viable, non‑proliferating eMSCs stimulated the development of all elements of decidual tissue. Conversely, transplantation of the rats with cells killed using 95% ethanol did not result in the development of decidual tissue. The present study demonstrated the potential for applying eMSCs to the cellular therapy of infertility associated with endometrial disorders characterized by decidualization insufficiency and implantation failure. In addition, the transplantation of viable but non‑proliferating cells ensured that their oncogenic potential was limited.
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1 

Wang S, Qu X and Zhao RC: Clinical applications of mesenchymal stem cells. J Hematol Oncol. 5:19–20. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Husein KS and Thiemermann C: Mesenchymal stromal cells: current understanding and clinical status. Stem Cells. 28:585–596. 2010.PubMed/NCBI

3 

Parker AM and Katz AJ: Adipose derived stem cells for the regeneration of damaged tissues. Expert Opin Bio Ther. 6:567–578. 2006. View Article : Google Scholar

4 

Harris DT, Badowski M, Ahmad N and Gaballa MA: The potential of cord blood stem cells for use in regenerative medicine. Exper Opin Biol Ther. 7:1311–1322. 2007. View Article : Google Scholar

5 

Coppi P, De Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, et al: Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 25:100–106. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Cho NH, Park YK, Kim YT, Yang H and Kim SK: Lifetime expression of stem cell markers in the uterine endometrium. Fertil Steril. 81:403–407. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Gargett CE: Identification and characterization of human endometrial stem/progenitor cells. Aust Nz J Obstet Gynaecol. 46:250–253. 2006. View Article : Google Scholar

8 

Gargett CE and Masuda H: Adult stem cells in the endometrium. Mol Hum Reprod. 16:818–834. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Meng X, Ichim TE, Zhong J, Rogers A, Yin Z, Jackson J, Wang H, Ge W, Bogin V, Chan KW, et al: Endometrial regenerative cells: A novel stem cell population. J Transl Med. 5:57–66. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Patel AN, Park E, Kuzman M, Benetti F, Silva FJ and Allickson JG: Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation. Cell Transplant. 17:303–311. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Dominina AP, Fridliandskaia II, Zemel'ko VI, Pugovkina NA, Kovaleva ZV, Zenin VV, Grinchuk TM and Nikol'skiĭ NN: Mesenchymal stem cells from human endometrium do not undergo spontaneous transformation during long-term cultivation. Cell tissue biol. 7:221–226. 2013. View Article : Google Scholar

12 

Murphy MP, Wang H, Patel AN, Kambhampati S, Angle N, Chan K, Marleau AM, Pyszniak A, Carrier E, Ichim TE and Riordan NH: Allogeneic endometrial regenerative cells: An ‘off the shelf solution’ for critical limb ischemia? J Transl Med. 6:452008. View Article : Google Scholar : PubMed/NCBI

13 

Mikhailov VM: Life cycle of decidual cells. Int Rev Cytol. 227:1–63. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Kim JJ, Taylor HS, Lu Z, Ladhani O, Hastings JM, Jackson KS, Wu Y, Guo SW and Fazleabas AT: Altered expression of HOXA10 in endometriosis: Potential role in decidualization. Mol Hum Reprod. 13:323–332. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Csemiczky G, Wramsby H, Johannisson E and Landgren BM: Importance of endometrial quality in women with tubal infertility during a natural menstrual cycle for the outcome of IVF treatment. J Assist Reprod Genet. 15:55–61. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Dmowski WP and Greenblatt RB: Asherman';s syndrome and risk of placenta accrete. Obstet Gynecol. 34:288–299. 1969.PubMed/NCBI

17 

Zhao Y, Wang A, Tang X, Li M, Yan L, Shang W and Gao M: Intrauterine transplantation of autologous bone marrow derived mesenchymal stem cells followed by conception in a patient of severe intrauterine adhesions. Open J Obstet Gynecol. 3:377–380. 2013. View Article : Google Scholar

18 

Nagori CB, Panchal SY and Patel H: Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman';s syndrome. J Hum Reprod Sci. 4:43–48. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Domnina AP, Zemelko VI, Mikhailov VM and Nikolsky NN: Stimulation of decidua development by transplantation of endometrial stem cells. J Biomed Sci Eng. 6:59–65. 2013. View Article : Google Scholar

20 

Grinchuk TM, Ivantsov KM, Alekseenko LL, Kozhukharova IV, Zaĭchik AM, Petrov NS, Mikhaĭlov VM and Popov BV: Characterization of cultured murine mesenchymal stem cell line expressing GFP. Tsitologiia. 50:1030–1035. 2008.(In Russian). PubMed/NCBI

21 

Popov BV, Petrov NS, Mikhaĭlov VM, Tomilin AN, Alekseenko LL, Grinchuk TM and Zaĭchik AM: Spontaneous transformation and immortalization of mesenchymal stem cells in vitro. Tsitologiia. 51:91–102. 2009.(In Russian). PubMed/NCBI

22 

Bernardo ME, Zaffaroni N, Novara F, Cometa AM, Avanzini MA, Moretta A, Montagna D, Maccario R, Villa R, Daidone MG, et al: Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res. 67:9142–9149. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Rubio D, Castro J Garcia, Martin MC, de la Fuente R, Cigudosa JC, Lloyd AC and Bernad A: Spontaneous human adult stem cell transformation. Cancer Res. 65:3035–3039. 2005.PubMed/NCBI

24 

Røsland GV, Svendsen A, Torsvik A, Sobala E, McCormack E, Immervoll H, Mysliwietz J, Tonn JC, Goldbrunner R, Lønning PE, et al: Long-term cultures of bone marrow derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 69:5331–5339. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Wu W, He Q, Li X, Zhang X, Lu A, Ge R, Zhen H, Chang AE, Li Q and Shen L: Long-term cultured human neural stem cells undergo spontaneous transformation to tumor-initiating cells. Int J Biol Sci. 7:892–901. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Torsvik A, Rosland GV and Bjerkvig R: Spontaneous transformation of stem cells in vitro and the issue of cross contamination. Int J Biol Sci. 8:1051–1052. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Sokolov MV and Neumann RD: Lessons learned about human stem cell responses to ionizing radiation exposures: A long road still ahead of us. Int J Mol Sci. 14:15695–15723. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Sokolov MV and Neumann RD: Radiation-induced bystander effects in cultured human stem cells. PLoS One. 5:e141952010. View Article : Google Scholar : PubMed/NCBI

29 

Nieto A, Cabrera CM, Catalina P, Cobo F, Barnie A, Cortés JL, del Jesus A Barroso, Montes R and Concha A: Effect of mitomycin C on human foreskin fibroblasts used as feeders in human embryonic stem cells: Immunocytochemistry MIB1 score and DNA ploidy and apoptosis evaluated by flow cytometry. Cell Biol Int. 31:269–278. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Hung DT, Jamison TF and Schreiber SL: Understanding and controlling the cell cycle with natural products. Chem Biol. 3:623–639. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Zemel'ko VI, Grinchuk TM, Domnina AP, Artsybasheva IV, Zenin VV, Kirsanov AA, Bichevaia NK, Korsak VS and Nikol'skiĭ NN: Multipotent mesenchymal stem cells of desquamated endometrium: Isolation, characterization and application as a feeder layer for maintenance of human embryonic stem cells. Cell Tiss Biol. 6.1:1–11. 2011.(In Russian).

32 

Cmielova J, Havelek R, Soukup T, Jiroutová A, Visek B, Suchánek J, Vavrova J, Mokry J, Muthna D, Bruckova L, et al: Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments. Int J Radiat Biol. 88:393–404. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Ko E, Lee KY and Hwang DS: Human umbilical cord blood-derived mesenchymal stem cells undergo cellular senescence in response to oxidative stress. Stem Cells Dev. 21:1877–1886. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Prockop DJ, Brenner M, Fibbe WE, Horwitz E, Le Blanc K, Phinney DG, Simmons PJ, Sensebe L and Keating A: Defining the risks of mesenchymal stromal cell therapy. Cytotherapy. 12:576–578. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Yu SP, Wei Z and Wei L: Preconditioning strategy in stem cell transplantation therapy. Transl Stroke Res. 4:76–88. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Yu P, Wei Z and Wei L: Preconditioning strategy in stem cell transplantation therapy. Transl Stroke Res. 4:76–88. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Alawadhi F, Du H, Cakmak H and Taylor HS: Bone marrow-derived stem cell (bmdsc) transplantation improves fertility in a murine model of Asherman's syndrome. PLoS One. 9:e966622014. View Article : Google Scholar : PubMed/NCBI

38 

Kilic S, Yuksel B, Pinarli F, Albayrak A, Boztok B and Delibasi T: Effect of stem cell application on Asherman syndrome, an experimental rat model. J Assist Reprod Genet. 31:975–982. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Jing Z, Hong G and Li Y: Development of an animal model for thin endometrium using 95% ethanol. J Fert In Vitro. 2:42012.

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Copy and paste a formatted citation
Spandidos Publications style
Domnina AP, Novikova PV, Lyublinskaya OG, Zenin VV, Fridlyanskaya II, Mikhailov VM and Nikolsky NN: Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats. Exp Ther Med 12: 2447-2454, 2016.
APA
Domnina, A.P., Novikova, P.V., Lyublinskaya, O.G., Zenin, V.V., Fridlyanskaya, I.I., Mikhailov, V.M., & Nikolsky, N.N. (2016). Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats. Experimental and Therapeutic Medicine, 12, 2447-2454. https://doi.org/10.3892/etm.2016.3671
MLA
Domnina, A. P., Novikova, P. V., Lyublinskaya, O. G., Zenin, V. V., Fridlyanskaya, I. I., Mikhailov, V. M., Nikolsky, N. N."Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats". Experimental and Therapeutic Medicine 12.4 (2016): 2447-2454.
Chicago
Domnina, A. P., Novikova, P. V., Lyublinskaya, O. G., Zenin, V. V., Fridlyanskaya, I. I., Mikhailov, V. M., Nikolsky, N. N."Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2447-2454. https://doi.org/10.3892/etm.2016.3671
Copy and paste a formatted citation
x
Spandidos Publications style
Domnina AP, Novikova PV, Lyublinskaya OG, Zenin VV, Fridlyanskaya II, Mikhailov VM and Nikolsky NN: Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats. Exp Ther Med 12: 2447-2454, 2016.
APA
Domnina, A.P., Novikova, P.V., Lyublinskaya, O.G., Zenin, V.V., Fridlyanskaya, I.I., Mikhailov, V.M., & Nikolsky, N.N. (2016). Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats. Experimental and Therapeutic Medicine, 12, 2447-2454. https://doi.org/10.3892/etm.2016.3671
MLA
Domnina, A. P., Novikova, P. V., Lyublinskaya, O. G., Zenin, V. V., Fridlyanskaya, I. I., Mikhailov, V. M., Nikolsky, N. N."Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats". Experimental and Therapeutic Medicine 12.4 (2016): 2447-2454.
Chicago
Domnina, A. P., Novikova, P. V., Lyublinskaya, O. G., Zenin, V. V., Fridlyanskaya, I. I., Mikhailov, V. M., Nikolsky, N. N."Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2447-2454. https://doi.org/10.3892/etm.2016.3671
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