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Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion

  • Authors:
    • Xiao-Jun Wu
    • Feng Gao
    • Xu Liu
    • Qing Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2617-2621
    |
    Published online on: September 7, 2016
       https://doi.org/10.3892/etm.2016.3681
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Abstract

The aim of the present study was to observe the clinical efficacy and safety of recombinant tissue plasminogen activator (rt-PA) combined with compound anisodine in treating central retinal artery occlusion (CRAO). Forty-eight patients diagnosed with CRAO were randomly divided into a treatment group (24 cases) and a control group (24 cases). For the control group, nitroglycerin, 654-2, methazolamide, puerarin and compound anisodine were used for the treatment, along with oxygen, massage and other conventional treatments. Besides conventional therapy, the treatment group was also given intravenous rt-PA thrombolysis. Visual acuity, fundus oculi, visual field changes were taken as indicators for efficacy evaluation. It was found that the total effective rate of the control group was 70.83%, while that for the treatment group was 91.67%, and the comparative difference between the two groups was of statistical significance (p<0.05). The visual field defect of the control group after treatment was approximately 74.26±12.91%, and the visual field defect of the treatment group after treatment approximately 35.08±16.33%; thus, the comparative difference was statistically significant (p<0.01). The comparative difference of the original contents of fibrous protein in blood in the treatment group before and after treatment was statistically significant (p<0.01). In conclusion, the result show that intravenous thrombolysis with rt-PA combined with compound anisodine is safe and effective in treating CRAO, which can significantly improve the prognosis of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wu X, Gao F, Liu X and Zhao Q: Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion. Exp Ther Med 12: 2617-2621, 2016.
APA
Wu, X., Gao, F., Liu, X., & Zhao, Q. (2016). Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion. Experimental and Therapeutic Medicine, 12, 2617-2621. https://doi.org/10.3892/etm.2016.3681
MLA
Wu, X., Gao, F., Liu, X., Zhao, Q."Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion". Experimental and Therapeutic Medicine 12.4 (2016): 2617-2621.
Chicago
Wu, X., Gao, F., Liu, X., Zhao, Q."Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2617-2621. https://doi.org/10.3892/etm.2016.3681
Copy and paste a formatted citation
x
Spandidos Publications style
Wu X, Gao F, Liu X and Zhao Q: Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion. Exp Ther Med 12: 2617-2621, 2016.
APA
Wu, X., Gao, F., Liu, X., & Zhao, Q. (2016). Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion. Experimental and Therapeutic Medicine, 12, 2617-2621. https://doi.org/10.3892/etm.2016.3681
MLA
Wu, X., Gao, F., Liu, X., Zhao, Q."Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion". Experimental and Therapeutic Medicine 12.4 (2016): 2617-2621.
Chicago
Wu, X., Gao, F., Liu, X., Zhao, Q."Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2617-2621. https://doi.org/10.3892/etm.2016.3681
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