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Article

Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature

  • Authors:
    • Na Duan
    • Xiao Chen
    • Yongkang Liu
    • Jianhua Wang
    • Zhongqiu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 2665-2670
    |
    Published online on: September 8, 2016
       https://doi.org/10.3892/etm.2016.3689
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Abstract

Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years. The second case was a 62-year-old female with arthritis in the larger joints for 5 years, particularly on the right thoracic area. The third case was a 44-year-old male who exhibited a slight bulge accompanied by pain in the upper anterior chest wall for 4 years. All of them lacked cutaneous lesions. CT demonstrated sclerosis and hyperostosis with subchondral erosions in the sternocostoclavicular joints. MRI revealed bone marrow edema that was slightly hypointense on T1‑weighted imaging, and hyperintense on T2‑weighted imaging. Typical ̔bull head̓ signs were observed in bone scintigraphy images. The present case study demonstrated that SAPHO syndrome should be suspected in patients with multifocal osteitis or arthritis affecting the chest wall that lack skin manifestations. Multimodal imaging modalities in combination are helpful for SAPHO diagnosis.
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1 

Chamot AM, Benhamou CL, Kahn MF, Beraneck L, Kaplan G and Prost A: Acne-pustulosishyperostosis-osteitis syndrome: Results of a national survey. 85 cases. Rev Rhum Mal Osteoartic. 54:187–196. 1987.(In French).

2 

Carneiro S and Sampaio-Barros PD: SAPHO syndrome. Rheum Dis Clin North Am. 39:401–418. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Judex AG, Freyschmidt J, Feuerbach S, Schölmerich J and Müller-Ladner U: Sequential combination therapy leading to sustained remission in a patient with SAPHO syndrome. Open Rheumatol J. 3:18–21. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Govoni M, Colina M, Massara A and Trotta F: SAPHO syndrome and infections. Autoimmun Rev. 8:256–259. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Sallés M, Olivé A, Perez-Andres R, Holgado S, Mateo L, Riera E and Tena X: The SAPHO syndrome: A clinical and imaging study. Clin Rheumatol. 30:245–249. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zhang LL, Zhao JX and Liu XY: Successful treatment of SAPHO syndrome with severe spinal disorder using entercept: A case study. Rheumatol Int. 32:1963–1965. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Zhao Z, Li Y, Li Y, Zhao H and Li H: Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with review of the relevant published work. J Dermatol. 38:155–159. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Song X, Sun W, Meng Z, Gong L, Tan J, Jia Q, Yu C and Yu T: Diagnosis and treatment of SAPHO syndrome: A case report. Exp Ther Med. 8:419–422. 2014.PubMed/NCBI

9 

Colina M, Govoni M, Orzincolo C and Trotta F: Clinical and radiologic evolution of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: A single center study of a cohort of 71 subjects. Arthritis Rheum. 61:813–821. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Nguyen MT, Borchers A, Selmi C, Naguwa SM, Cheema G and Gershwin ME: The SAPHO syndrome. Semin Arthritis Rheum. 42:254–265. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Takigawa T, Tanaka M, Nakahara S, Sugimoto Y and Ozaki T: SAPHO syndrome with rapidly progressing destructive spondylitis: Two cases treated surgically. Eur Spine J. 17 Suppl 2:331–337. 2008. View Article : Google Scholar

12 

Benhamou CL, Chamot AM and Kahn MF: Synovitis-acne-pustulosis hyperostosis-osteomyelitis syndrome (SAPHO) A new syndrome among the spondyloarthropathies? Clin Exp Rheumatol. 6:109–112. 1988.PubMed/NCBI

13 

Sweeney SA, Kumar VA, Tayar J, Weber DM, Safdar A, Alonso C and Hymes S: Case 181: Synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. Radiology. 263:613–617. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Depasquale R, Kumar N, Lalam RK, Tins BJ, Tyrrell PN, Singh J and Cassar-Pullicino VN: SAPHO: What radiologists should know. Clin Radiol. 67:195–206. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Earwaker JW and Cotten A: SAPHO: Syndrome or concept? Imaging findings. Skeletal Radiol. 32:311–327. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Freyschmidt J and Sternberg A: The bullhead sign: Scintigraphic pattern of sternocostoclavicular hyperostosis and pustulotic arthroosteitis. Eur Radiol. 8:807–812. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Fritz P, Baldauf G, Wilke HJ and Reitter I: Sternocostoclavicular hyperostosis: Its progression and radiological features. A study of 12 cases. Ann Rheum Dis. 51:658–664. 1992. View Article : Google Scholar

18 

Laredo JD, Vuillemin-Bodaghi V, Boutry N, Cotten A and Parlier-Cuau C: SAPHO syndrome: MR appearance of vertebral involvement. Radiology. 242:825–831. 2007. View Article : Google Scholar : PubMed/NCBI

19 

van Doornum S, Barraclough D, McColl G and Wicks I: SAPHO: Rare or just not recognized? Semin Arthritis Rheum. 30:70–77. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Pahlavan PS and Leslie WD: Multiple imaging findings in SAPHO syndrome. Clin Nucl Med. 33:912–915. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Patel CN, Smith JT, Rankine JJ and Scarsbrook AF: F-18 FDG PET/CT can help differentiate SAPHO syndrome from suspected metastatic bone disease. Clin Nucl Med. 34:254–257. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Boutin RD and Resnick D: The SAPHO syndrome: An evolving concept for unifying several idiopathic disorders of bone and skin. AJR Am J Roentgenol. 170:585–591. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Zemann W, Pau M, Feichtinger M, Ferra-Matschy B and Kaercher H: SAPHO syndrome with affection of the mandible: Diagnosis, treatment, and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 111:190–195. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Shikino K, Ikusaka M and Hirota Y: Magnetic resonance imaging of sternoclavicular joint arthritis due to SAPHO syndrome. Int J Case Rep Images. 5:462–464. 2014. View Article : Google Scholar

25 

Rodríguez M Quirico, Casáns Tormo I, Redal Peña MC and López Castillo V: The importance of bone scintigraphy in the diagnosis of SAPHO syndrome. Rev Esp Med Nucl. 29:127–130. 2010.(In Spanish). View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Duan N, Chen X, Liu Y, Wang J and Wang Z: Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature. Exp Ther Med 12: 2665-2670, 2016.
APA
Duan, N., Chen, X., Liu, Y., Wang, J., & Wang, Z. (2016). Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature. Experimental and Therapeutic Medicine, 12, 2665-2670. https://doi.org/10.3892/etm.2016.3689
MLA
Duan, N., Chen, X., Liu, Y., Wang, J., Wang, Z."Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature". Experimental and Therapeutic Medicine 12.4 (2016): 2665-2670.
Chicago
Duan, N., Chen, X., Liu, Y., Wang, J., Wang, Z."Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2665-2670. https://doi.org/10.3892/etm.2016.3689
Copy and paste a formatted citation
x
Spandidos Publications style
Duan N, Chen X, Liu Y, Wang J and Wang Z: Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature. Exp Ther Med 12: 2665-2670, 2016.
APA
Duan, N., Chen, X., Liu, Y., Wang, J., & Wang, Z. (2016). Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature. Experimental and Therapeutic Medicine, 12, 2665-2670. https://doi.org/10.3892/etm.2016.3689
MLA
Duan, N., Chen, X., Liu, Y., Wang, J., Wang, Z."Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature". Experimental and Therapeutic Medicine 12.4 (2016): 2665-2670.
Chicago
Duan, N., Chen, X., Liu, Y., Wang, J., Wang, Z."Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2665-2670. https://doi.org/10.3892/etm.2016.3689
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