Open Access

Effects of dexpanthenol on acetic acid‑induced colitis in rats

  • Authors:
    • Yasir Furkan Cagin
    • Hakan Parlakpinar
    • Nigar Vardi
    • Alaadin Polat
    • Yahya Atayan
    • Mehmet Ali Erdogan
    • Kevser Tanbek
  • View Affiliations

  • Published online on: September 20, 2016     https://doi.org/10.3892/etm.2016.3728
  • Pages: 2958-2964
  • Copyright: © Cagin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

While the pathogenesis of acetic acid (AA)‑induced colitis is unclear, reactive oxygen species are considered to have a significant effect. The aim of the present study was to elucidate the therapeutic potential of dexpanthenol (Dxp) on the amelioration of colitis in rats. Group I (n=8; control group) was intrarectally administered 1 ml saline solution (0.9%); group II [n=8; AA] was administered 4% AA into the colon via the rectum as a single dose for three consecutive days; group III (n=8; AA + Dxp) was administered AA at the same dosage as group II from day 4, and a single dose of Dxp was administered intraperitoneally; and group IV (n=8; Dxp) was administered Dxp similarly to Group III. Oxidative stress and colonic damage were assessed via biochemical and histologic examination methods. AA treatment led to an increase in oxidative parameters and a decrease in antioxidant systems. Histopathological examination showed that AA treatment caused tissue injury and increased caspase‑3 activity in the distal colon and triggered apoptosis. Dxp treatment caused biochemical and histopathological improvements, indicating that Dxp may have an anti‑oxidant effect in colitis; therefore, Dxp may be a potential therapeutic agent for the amelioration of IBD.
View Figures
View References

Related Articles

Journal Cover

November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cagin YF, Parlakpinar H, Vardi N, Polat A, Atayan Y, Erdogan MA and Tanbek K: Effects of dexpanthenol on acetic acid‑induced colitis in rats. Exp Ther Med 12: 2958-2964, 2016.
APA
Cagin, Y.F., Parlakpinar, H., Vardi, N., Polat, A., Atayan, Y., Erdogan, M.A., & Tanbek, K. (2016). Effects of dexpanthenol on acetic acid‑induced colitis in rats. Experimental and Therapeutic Medicine, 12, 2958-2964. https://doi.org/10.3892/etm.2016.3728
MLA
Cagin, Y. F., Parlakpinar, H., Vardi, N., Polat, A., Atayan, Y., Erdogan, M. A., Tanbek, K."Effects of dexpanthenol on acetic acid‑induced colitis in rats". Experimental and Therapeutic Medicine 12.5 (2016): 2958-2964.
Chicago
Cagin, Y. F., Parlakpinar, H., Vardi, N., Polat, A., Atayan, Y., Erdogan, M. A., Tanbek, K."Effects of dexpanthenol on acetic acid‑induced colitis in rats". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2958-2964. https://doi.org/10.3892/etm.2016.3728