Lutetium 177‑DOTA‑TATE therapy for esthesioneuroblastoma: A case report

Sabongi,Juliano Guerra; Gonçalves,Mônica Carboni Pereira; Alves,Cira Danielle Casado; Alves,João; Scapulatempo‑Neto,Cristovam; Moriguchi,Sonia Marta

doi:10.3892/etm.2016.3732

Lutetium 177‑DOTA‑TATE therapy for esthesioneuroblastoma: A case report

Authors:
- Juliano Guerra Sabongi
- Mônica Carboni Pereira Gonçalves
- Cira Danielle Casado Alves
- João Alves
- Cristovam Scapulatempo‑Neto
- Sonia Marta Moriguchi
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Affiliations: Imaging Medical Center, Division of Nuclear Medicine, Medical Centre of Sorocaba, Sorocaba, SP 18031‑480, Brazil, Department of Nuclear Medicine, Barretos Cancer Hospital, Barretos, SP 14780‑000, Brazil, Department of Head and Neck Surgery, Barretos Cancer Hospital, Barretos, SP 14780‑000, Brazil, Department of Nuclear Medicine, Dr Ary Pinheiro Base Hospital, Porto Velho, RO 76804‑373, Brazil, Department of Pathological Anatomy, Barretos Cancer Hospital, Barretos, SP 18600‑000, Brazil, Department of Tropical Diseases and Diagnostic Imaging, Botucatu Medical School, São Paulo State University, Botucatu, SP 18618‑970, Brazil
Published online on: September 20, 2016 https://doi.org/10.3892/etm.2016.3732
Pages: 3078-3082

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Abstract

Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high. Treatment of neuroendocrine tumors using radionuclides bound to somatostatin analogues is well established in clinical practice. However, a standard and effective therapeutic approach has not been reported for ENB. The current study described the case of a 74‑year‑old female with numerous recurrences of ENB following multiple treatments and without possibility of resection. The patient was treated with the radiolabeled‑somatostatin analogue, 177Lutetium‑DOTA‑octreotate (177Lu‑DOTA‑TATE), which successfully controlled the disease. This suggests that 177Lu‑DOTA‑TATE is a potential treatment for ENB and may represent an effective alternative and novel therapeutic strategy for this disease.

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