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Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study

  • Authors:
    • Qi-Jun Chen
    • Zhi-Yong Yang
    • Chun-You Wang
    • Li-Ming Dong
    • Yu-Shun Zhang
    • Chao Xie
    • Chang-Zhong Chen
    • Shi-Kai Zhu
    • Hong-Ji Yang
    • He-Shui Wu
    • Chong Yang
  • View Affiliations / Copyright

    Affiliations: Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Microarray Core Facility, Dana-Farber Cancer Institute, Boston, MA 02138, USA, Organ Transplantation Center, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3213-3220
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    Published online on: September 23, 2016
       https://doi.org/10.3892/etm.2016.3744
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Abstract

In the present study, we investigated the effects of hydroxyethyl starch (HES) 130/0.4 on serum pro-inflammatory variables, immunologic variables, fluid balance (FB)-negative(-) rate and renal function in severe acute pancreatitis (SAP) patients. From October, 2007 to November, 2008, a total of 120 SAP patients were enrolled in this retrospective study. Fifty‑nine patients in the HES group received 6% HES 130/0.4 combined with crystalloid solution for fluid resuscitation (HES group). In the control group, 61 patients received only crystalloid solution after admission. Interleukin (IL)-1, IL-6, IL-8 and tumor necrosis factor (TNF)-α levels in serum were measured on days 1, 2, 4 and 8. The peripheral blood CD4+CD8+ T lymphocyte rates, serum BUN and Cr values were also measured on days 1, 4 and 8. Patients with FB(-) rates were recorded from day 1 to 8. Interaction term analysis (hospital stay and fluid resuscitation methods) based on mixed-effects regression model revealed significantly lower levels of IL-1 and TNF-α in the HES group compared with the control group. The difference in curve's risk ratio was not significant for IL-6, CD4+CD8+ T lymphocyte rate, BUN and Cr values (P>0.05). In the HES group, we detected a significantly higher rate of patients with FB(-) from day 4 to 8 (P<0.05). Thus, HES 130/0.4 resuscitation could decrease the IL-1 and IL-8 levels, shorten the duration of positive FB, and preserve the patient's immune status as well as renal function during the early phase of SAP.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Q, Yang Z, Wang C, Dong L, Zhang Y, Xie C, Chen C, Zhu S, Yang H, Wu H, Wu H, et al: Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study. Exp Ther Med 12: 3213-3220, 2016.
APA
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C. ... Yang, C. (2016). Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study. Experimental and Therapeutic Medicine, 12, 3213-3220. https://doi.org/10.3892/etm.2016.3744
MLA
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C., Chen, C., Zhu, S., Yang, H., Wu, H., Yang, C."Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study". Experimental and Therapeutic Medicine 12.5 (2016): 3213-3220.
Chicago
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C., Chen, C., Zhu, S., Yang, H., Wu, H., Yang, C."Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3213-3220. https://doi.org/10.3892/etm.2016.3744
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q, Yang Z, Wang C, Dong L, Zhang Y, Xie C, Chen C, Zhu S, Yang H, Wu H, Wu H, et al: Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study. Exp Ther Med 12: 3213-3220, 2016.
APA
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C. ... Yang, C. (2016). Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study. Experimental and Therapeutic Medicine, 12, 3213-3220. https://doi.org/10.3892/etm.2016.3744
MLA
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C., Chen, C., Zhu, S., Yang, H., Wu, H., Yang, C."Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study". Experimental and Therapeutic Medicine 12.5 (2016): 3213-3220.
Chicago
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C., Chen, C., Zhu, S., Yang, H., Wu, H., Yang, C."Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3213-3220. https://doi.org/10.3892/etm.2016.3744
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