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Article

Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation

  • Authors:
    • Hui Yue
    • Jinyu Han
    • Ling Liu
    • Kaiyuan Wang
    • Jincheng Li
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China
  • Pages: 3785-3789
    |
    Published online on: October 20, 2016
       https://doi.org/10.3892/etm.2016.3829
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Abstract

The aim of the present study was to investigate the effect of various doses of rocuronium on bispectral index (BIS) responses to propofol induction and tracheal intubation, as well as the role of the non‑depolarization muscle relaxant rocuronium on the depth of sedation. A total of 72 patients (American Society of Anesthesiologists physical status I‑II) were anaesthetized with propofol using a target‑controlled infusion, and randomly divided into two sedation level groups (n=36). The patients were divided into 2 groups according to the BIS value: A normal sedation group (group 1), with a stable BIS value at 40‑60, and a deep sedation group (group 2), with a BIS value <20 or with burst suppression. Each group was randomly divided into 4 subgroups A‑D (n=9) according to the various doses of rocuronium (0.3, 0.6, 0.9 and 1.2 mg/kg). Tracheal intubation was performed after 2 min of rocuronium administration. BIS, electromyography (EMG), heart rate (HR) and mean arterial pressure (MAP) were recorded continuously and averaged over 1 min during baseline (T1), steady state (T2), 2 min after rocuronium infusion (T3), and 0, 2 and 5 min after tracheal intubation. The results demonstrated that HR and MAP decreased significantly at T2 and T3 compared with T1. Following tracheal intubation (L0), HR and MAP significantly increased compared with T2 and T3, and returned to levels similar to those prior to intubation after 5 min. In group 1C and 1D, BIS was significantly decreased at T3 compared with T2; BIS was significantly increased at L0 compared with T3 in group 1A and 1B. EMG at earlier stages of anesthesia was significantly higher compared with other points, and was significantly increased at L0 compared with T3 in group 1A and 1B. These results demonstrated that BIS response may be associated with the dosage of rocuronium in the normal sedation group, although no association was observed with the deep sedation group. Tracheal intubation resulted in marked hemodynamic changes under both normal and deep sedation.
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1 

Huang YF, Pryor ME, Mather LE and Veering BT: Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. Anesth Analg. 86:797–804. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Gazzanelli S, Vari A, Tarquini S, Fermariello A, Caputo M, Almansour M, Costi U, Basso L, Casullo L and Izzo L: Monitoring of consciousness with BIS during induction of anesthesia. G Chir. 26:163–169. 2005.PubMed/NCBI

3 

Gao JD, Zhao YJ, Xu CS, Zhao J, Huang YG, Wang TL, Pei L, Wang J, Yao LN, Ding Q, et al: Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: A multicenter clinical trial. Chin Med J (Engl). 125:1389–1392. 2012.PubMed/NCBI

4 

Hans P, Giwer J, Brichant JF, Dewandre PY and Bonhomme V: Effect of an intubation dose of rocuronium on spectral entropy and bispectral index responses to laryngoscopy during propofol anaesthesia. Br J Anaesth. 97:842–847. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Pomfrett CJ: Heart rate variability, BIS and 'depth of anaesthesia'. Br J Anaesth. 82:659–662. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Sie MY, Goh PK, Chan L and Ong SY: Bispectral index during modified rapid sequence induction using thiopentone or propofol and rocuronium. Anaesth Intensive Care. 32:28–30. 2004.PubMed/NCBI

7 

Forbes A, Cohen N and Eger EI II: Pancuronium reduces halothane requirement in man. Anesth Analg. 58:497–499. 1979. View Article : Google Scholar : PubMed/NCBI

8 

Riess ML, Graefe UA, Goeters C, Van Aken H and Bone HG: Sedation assessment in critically ill patients with bispectral index. Eur J Anaesthesiol. 19:18–22. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Prell J, Rampp S, Ache J, Laule S, Rachinger J, Scheller C, Alfieri A and Strauss C: The potential of quantified lower cranial nerve EMG for monitoring of anesthetic depth. J Neurosurg Anesthesiol. 24:139–145. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Vivien B, Di Maria S, Ouattara A, Langeron O, Coriat P and Riou B: Overestimation of Bispectral Index in sedated intensive care unit patients revealed by administration of muscle relaxant. Anesthesiology. 99:9–17. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Park SJ, Cho YJ, Oh JH, Hwang JW, Do SH and Na HS: Pretreatment of magnesium sulphate improves intubating conditions of rapid sequence tracheal intubation using alfentanil, propofol, and rocuronium-a randomized trial. Korean J Anesthesiol. 65:221–227. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Kawaguchi M, Takamatsu I and Kazama T: Rocuronium dose-dependently suppresses the spectral entropy response to tracheal intubation during propofol anaesthesia. Br J Anaesth. 102:667–672. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Pearsall FJ, Davidson JA and Asbury AJ: Attitudes to the Association of Anaesthetists recommendations for standards of monitoring during anaesthesia and recovery. Anaesthesia. 50:649–653. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Chun H, Kang J, Kim KJ, Park KS and Kim HC: IT-based diagnostic instrumentation systems for personalized healthcare services. Stud Health Technol Inform. 117:180–190. 2005.PubMed/NCBI

15 

Iannuzzi M, Iannuzzi E, Rossi F, Berrino L and Chiefari M: Relationship between bispectral index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints. Br J Anaesth. 94:492–495. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Morimoto Y, Hagihira S, Koizumi Y, Ishida K, Matsumoto M and Sakabe T: The relationship between bispectral index and electroencephalographic parameters during isoflurane anesthesia. Anesth Analg. 98:1336–1340. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Rampil IJ: A primer for EEG signal processing in anesthesia. Anesthesiology. 89:980–1002. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Hosseinzadeh H and Asl M Nassiri: Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice. BMC Pharmacol. 3:32003. View Article : Google Scholar : PubMed/NCBI

19 

Sanford TJ Jr, Weinger MB, Smith NT, Benthuysen JL, Head N, Silver H and Blasco TA: Pretreatment with sedative-hypnotics, but not with nondepolarizing muscle relaxants, attenuates alfentanil-induced muscle rigidity. J Clin Anesth. 6:473–480. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Dahaba AA, Mattweber M, Fuchs A, Zenz W, Rehak PH, List WF and Metzler H: The effect of different stages of neuromuscular block on the bispectral index and the bispectral index-XP under remifentanil/propofol anesthesia. Anesth Analg. 99:781–787. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Dahaba AA, Bornemann H, Hopfgartner E, Ohran M, Kocher K, Liebmann M, Wilfinger G and Metzler H: Effect of sugammadex or neostigmine neuromuscular block reversal on bispectral index monitoring of propofol/remifentanil anaesthesia. Br J Anaesth. 108:602–606. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Aho AJ, Kamata K, Yli-Hankala A, Lyytikäinen LP, Kulkas A and Jäntti V: Elevated BIS and Entropy values after sugammadex or neostigmine: An electroencephalographic or electromyographic phenomenon? Acta Anaesthesiol Scand. 56:465–473. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Mi WD, Sakai T, Takahashi S and Matsuki A: Haemodynamic and electroencephalograph responses to intubation during induction with propofol or propofol/fentanyl. Can J Anaesth. 45:19–22. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Guignard B, Menigaux C, Dupont X, Fletcher D and Chauvin M: The effect of remifentanil on the bispectral index change and hemodynamic responses after orotracheal intubation. Anesth Analg. 90:161–167. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Ekman A, Lindholm ML, Lennmarken C and Sandin R: Reduction in the incidence of awareness using BIS monitoring. Acta Anaesthesiol Scand. 48:20–26. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Sugiura S, Hidaka K, Seki S and Tsuchida H: Comparative study of two beta adrenergic antagonists on hemodynamics at the endotracheal intubation. Anesthesiology. 107:A3092007.

27 

Messieha ZS, Guirguis S and Hanna S: Bispectral index monitoring (BIS) as a guide for intubation without neuromuscular blockade in office-based pediatric general anesthesia: A retrospective evaluation. Anesth Prog. 58:3–7. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Messner M, Beese U, Romstöck J, Dinkel M and Tschaikowsky K: The bispectral index declines during neuromuscular block in fully awake persons. Anesth Analg. 97:488–491. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Albertin A, Casati A, Federica L, Roberto V, Travaglini V, Bergonzi P and Torri G: The effect-site concentration of remifentanil blunting cardiovascular responses to tracheal intubation and skin incision during bispectral index-guided propofol anesthesia. Anesth Analg. 101:125–130. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yue H, Han J, Liu L, Wang K and Li J: Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation. Exp Ther Med 12: 3785-3789, 2016.
APA
Yue, H., Han, J., Liu, L., Wang, K., & Li, J. (2016). Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation. Experimental and Therapeutic Medicine, 12, 3785-3789. https://doi.org/10.3892/etm.2016.3829
MLA
Yue, H., Han, J., Liu, L., Wang, K., Li, J."Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation". Experimental and Therapeutic Medicine 12.6 (2016): 3785-3789.
Chicago
Yue, H., Han, J., Liu, L., Wang, K., Li, J."Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3785-3789. https://doi.org/10.3892/etm.2016.3829
Copy and paste a formatted citation
x
Spandidos Publications style
Yue H, Han J, Liu L, Wang K and Li J: Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation. Exp Ther Med 12: 3785-3789, 2016.
APA
Yue, H., Han, J., Liu, L., Wang, K., & Li, J. (2016). Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation. Experimental and Therapeutic Medicine, 12, 3785-3789. https://doi.org/10.3892/etm.2016.3829
MLA
Yue, H., Han, J., Liu, L., Wang, K., Li, J."Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation". Experimental and Therapeutic Medicine 12.6 (2016): 3785-3789.
Chicago
Yue, H., Han, J., Liu, L., Wang, K., Li, J."Effect of rocuronium on the bispectral index under anesthesia and tracheal intubation". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3785-3789. https://doi.org/10.3892/etm.2016.3829
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