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Article

Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK

  • Authors:
    • Jiansheng Wang
    • Baishan Su
    • Hongbin Zhu
    • Chao Chen
    • Gang Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Second Hospital of Tangshan, Tangshan, Hebei 063000, P.R. China
  • Pages: 3607-3613
    |
    Published online on: October 27, 2016
       https://doi.org/10.3892/etm.2016.3850
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Abstract

Geraniol is a type of monoterpenoid with a rose scent and a slightly sweet flavor. It is found in the volatile oil of various plants, and has anti-inflammatory and anti‑oxidant effects. The present study aimed to investigate the protective effect of geraniol in inhibiting the inflammatory response, oxidative stress and apoptosis in traumatic spinal cord injury (SCI), as well as to analyze the mechanism underlying its effect. Adult male Sprague‑Dawley rats were induced to traumatic SCI through a surgical procedure and were defined as the SCI model group. SCI or normal rats were then administered 250 mg/kg/day geraniol for 4 weeks. The Basso, Beattie and Bresnahan (BBB) test and the spinal cord water content were used to analyze the effect of geraniol against traumatic SCI in rats. The inflammatory response, oxidative stress, and caspase‑9 and ‑3 activities were measured using commercial ELISA kits. In addition, the associated mechanism was analyzed, using western blot analysis to determine the protein expression levels of nuclear factor (NF)‑κB and p38 mitogen-activated protein kinase (MAPK). The results of the present study demonstrated that BBB scores were significantly increased and the spinal cord water content was significantly inhibited in SCI rats after 3 weeks of geraniol treatment. Furthermore, the inflammatory response, oxidative stress, and the caspase‑9 and ‑3 activities were significantly suppressed upon treatment with geraniol. Finally, the mechanism of geraniol against traumatic SCI downregulated the NF‑κB and p38 MAPK pathways in SCI rats. Therefore, the protective effect of geraniol is suggested to inhibit the inflammatory response, oxidative stress and apoptosis in traumatic SCI through the modulation of NF-κB and p38 MAPK.
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1 

Kuo CY, Liou TH, Chang KH, Chi WC, Escorpizo R, Yen CF, Liao HF, Chiou HY, Chiu WT and Tsai JT: Functioning and disability analysis of patients with traumatic brain injury and spinal cord injury by using the world health organization disability assessment schedule 2.0. Int J Environ Res Public Health. 12:4116–4127. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Lin B, Xu Y, Zhang B, He Y, Yan Y and He MC: MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury. Exp Ther Med. 7:66–72. 2014.PubMed/NCBI

3 

Turbes CC: Repair, reconstruction, regeneration and rehabilitation strategies to spinal cord injury. Biomed Sci Instrum. 34:351–356. 1997.PubMed/NCBI

4 

Reichenfelser W, Hackl H, Hufgard J, Kastner J, Gstaltner K and Gföhler M: Monitoring of spasticity and functional ability in individuals with incomplete spinal cord injury with a functional electrical stimulation cycling system. J Rehabil Med. 44:444–449. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Emon ST, Irban AG, Bozkurt SU, Akakin D, Konya D and Ozgen S: Effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury. Turk Neurosurg. 21:197–202. 2011.PubMed/NCBI

6 

Vuckovic A, Hasan MA, Fraser M, Conway BA, Nasseroleslami B and Allan DB: Dynamic oscillatory signatures of central neuropathic pain in spinal cord injury. J Pain. 15:645–655. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Tederko P, Krasuski M, Ptyushkin P, Selb M, Pawlak K, Skrzypczyk R and Escorpizo R: Need for a comprehensive epidemiologic study of spinal cord injury in Poland: Findings from a systematic review. Spinal Cord. 51:802–808. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Price S: Specific anosmia to geraniol in mice. Neurosci Lett. 4:49–50. 1977. View Article : Google Scholar : PubMed/NCBI

9 

Lapczynski A, Bhatia SP, Foxenberg RJ, Letizia CS and Api AM: Fragrance material review on geraniol. Food Chem Toxicol. 46:(Suppl 11). S160–S170. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Merlini V, Luparia M, Porta A, Zanoni G and Vidari G: Biomimetic cyclization of geraniol derivatives, a useful tool in the total synthesis of bioactive monocyclic terpenoids. Nat Prod Commun. 6:465–476. 2011.PubMed/NCBI

11 

Leite MC, de Brito Bezerra AP, de Sousa JP and de Oliveira Lima E: Investigating the antifungal activity and mechanism(s) of geraniol against Candida albicans strains. Med Mycol. 53:275–284. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A and Noble-Haeusslein LJ: Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci. 26:9841–9850. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Basso DM, Beattie MS, Bresnahan JC, Anderson DK, Faden AI, Gruner JA, Holford TR, Hsu CY, Noble LJ, Nockels R, et al: MASCIS evaluation of open field locomotor scores: Effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma. 13:343–359. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Weeks DL, Greer CL, Bray BS, Schwartz CR and White JR Jr: Association of antidepressant medication therapy with inpatient rehabilitation outcomes for stroke, traumatic brain injury, or traumatic spinal cord injury. Arch Phys Med Rehabil. 92:683–695. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Zhang X, Chen C, Ma S, Wang Y, Zhang X and Su X: Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord injury. Mol Med Rep. 11:4262–4266. 2015.PubMed/NCBI

16 

Tan J, Zhang F, Liang F, Wang Y, Li Z, Yang J and Liu X: Protective effects of hyperbaric oxygen treatment against spinal cord injury in rats via toll-like receptor 2/nuclear factor-κB signaling. Int J Clin Exp Pathol. 7:1911–1919. 2014.PubMed/NCBI

17 

Yao AH, Jia LY, Zhang YK, Ma QR, Cheng P, Liu L, Ju G and Kuang F: Early blockade of TLRs MyD88-dependent pathway may reduce secondary spinal cord injury in the rats. Evid Based Complement Alternat Med. 2012:5912982012. View Article : Google Scholar : PubMed/NCBI

18 

Marcuzzi A, Crovella S and Pontillo A: Geraniol rescues inflammation in cellular and animal models of mevalonate kinase deficiency. In Vivo. 25:87–92. 2011.PubMed/NCBI

19 

Chaudhary SC, Siddiqui MS, Athar M and Alam MS: Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis. J Appl Toxicol. 33:828–837. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Zuo DC, Choi S, Shahi PK, Kim MY, Park CG, Kim YD, Lee J, Chang IY, So I and Jun JY: Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase. World J Gastroenterol. 19:1210–1218. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Raha S, Lee HJ, Yumnam S, Hong GE, Saralamma VV, Ha YL, Kim JO, Kim YS, Heo JD, Lee SJ, Eun HK and Kim GS: Vitamin D2 suppresses amyloid-beta 25–35 induced microglial activation in BV2 cells by blocking the NF-kappaB inflammatory signaling pathway. Life Sci. July 28–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

22 

Yarar-Fisher C, Bickel CS, Kelly NA, Stec MJ, Windham ST, McLain AB, Oster RA and Bamman MM: Heightened TWEAK-NF-kappaB signaling and inflammation-associated fibrosis in paralyzed muscles of men with chronic spinal cord injury. Am J Physiol Endocrinol Metab. 310:E754–E761. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Khan AQ, Khan R, Qamar W, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Hasan SK and Sultana S: Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: Possible role of p38 MAP Kinase and NF-κB. Exp Mol Pathol. 94:419–429. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Su YW, Chao SH, Lee MH, Ou TY and Tsai YC: Inhibitory effects of citronellol and geraniol on nitric oxide and prostaglandin E2 production in macrophages. Planta Med. 76:1666–1671. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Xiong Y, Rabchevsky AG and Hall ED: Role of peroxynitrite in secondary oxidative damage after spinal cord injury. J Neurochem. 100:639–649. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Leski ML, Bao F, Wu L, Qian H, Sun D and Liu D: Protein and DNA oxidation in spinal injury: Neurofilaments - an oxidation target. Free Radic Biol Med. 30:613–624. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Knechtle B, Müller G, Willmann F, Eser P and Knecht H: Comparison of fat oxidation in arm cranking in spinal cord-injured people versus ergometry in cyclists. Eur J Appl Physiol. 90:614–619. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Bao F, Chen Y, Dekaban GA and Weaver LC: An anti-CD11d integrin antibody reduces cyclooxygenase-2 expression and protein and DNA oxidation after spinal cord injury in rats. J Neurochem. 90:1194–1204. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Hagvall L, Bäcktorp C, Svensson S, Nyman G, Börje A and Karlberg AT: Fragrance compound geraniol forms contact allergens on air exposure. Identification and quantification of oxidation products and effect on skin sensitization. Chem Res Toxicol. 20:807–814. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Prasad SN and Muralidhara: Protective effects of geraniol (a monoterpene) in a diabetic neuropathy rat model: Attenuation of behavioral impairments and biochemical perturbations. J Neurosci Res. 92:1205–1216. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Rodríguez-Barrera R, Fernández-Presas AM, García E, Flores-Romero A, Martiñón S, González-Puertos VY, Mestre H, Flores-Dominguez C, Rodriguez-Mata V, Königsberg M, et al: Immunization with a neural-derived peptide protects the spinal cord from apoptosis after traumatic injury. Biomed Res Int. 2013:8275172013. View Article : Google Scholar : PubMed/NCBI

32 

Vinothkumar V, Manoharan S, Sindhu G, Nirmal MR and Vetrichelvi V: Geraniol modulates cell proliferation, apoptosis, inflammation, and angiogenesis during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Mol Cell Biochem. 369:17–25. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Gong G, Yuan L, Cai L, Ran M, Zhang Y, Gong H, Dai X, Wu W and Dong H: Tetramethylpyrazine suppresses transient oxygen-glucose deprivation-induced connexin32 expression and cell apoptosis via the ERK1/2 and p38 MAPK pathway in cultured hippocampal neurons. PLoS One. 9:e1059442014. View Article : Google Scholar : PubMed/NCBI

34 

Kim JH, Choi JS and Lee BH: PI3K/Akt and MAPK pathways evoke activation of FoxO transcription factor to undergo neuronal apoptosis in brain of the silkworm Bombyx mori (Lepidoptera: Bombycidae). Cell Mol Biol (Noisy-le-grand) Suppl. 58:OL1780–OL1785. 2012.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Su B, Zhu H, Chen C and Zhao G: Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK. Exp Ther Med 12: 3607-3613, 2016.
APA
Wang, J., Su, B., Zhu, H., Chen, C., & Zhao, G. (2016). Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK. Experimental and Therapeutic Medicine, 12, 3607-3613. https://doi.org/10.3892/etm.2016.3850
MLA
Wang, J., Su, B., Zhu, H., Chen, C., Zhao, G."Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK". Experimental and Therapeutic Medicine 12.6 (2016): 3607-3613.
Chicago
Wang, J., Su, B., Zhu, H., Chen, C., Zhao, G."Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3607-3613. https://doi.org/10.3892/etm.2016.3850
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Su B, Zhu H, Chen C and Zhao G: Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK. Exp Ther Med 12: 3607-3613, 2016.
APA
Wang, J., Su, B., Zhu, H., Chen, C., & Zhao, G. (2016). Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK. Experimental and Therapeutic Medicine, 12, 3607-3613. https://doi.org/10.3892/etm.2016.3850
MLA
Wang, J., Su, B., Zhu, H., Chen, C., Zhao, G."Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK". Experimental and Therapeutic Medicine 12.6 (2016): 3607-3613.
Chicago
Wang, J., Su, B., Zhu, H., Chen, C., Zhao, G."Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-κB and p38 MAPK". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3607-3613. https://doi.org/10.3892/etm.2016.3850
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