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Article

18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats

  • Authors:
    • Weina Xu
    • Shupeng Yu
    • Jun Xin
    • Qiyong Guo
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China, Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China
  • Pages: 4154-4158
    |
    Published online on: November 3, 2016
       https://doi.org/10.3892/etm.2016.3869
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Abstract

The present study aimed to evaluate the early therapeutic effects of chemotherapy on Walker 256 tumor-bearing Wistar rats via F-18-fluoro-3'-deoxy-3'-L-fluorothymidine (18F-FLT) and F-18-fluoro-deoxyglucose (18F-FDG) positron emission tomography‑computed tomography (PET‑CT) imaging. Walker 256 tumor‑bearing Wistar rats were subjected to 18F‑FLT and 18F‑FDG PET‑CT imaging prior to and 24 and 48 h after epirubicin chemotherapy. 18F‑FLT and 18F‑FDG uptake [tumor/muscle (T/M)], the percentage of injected dose per gram (% ID/g), and the Ki‑67 labeling index (LI‑Ki‑67) were quantitatively determined for each rat prior to and following epirubicin chemotherapy. The correlation between % ID/g and tumor LI‑Ki‑67 was analyzed. Both 18F‑FLT and 18F‑FDG tumor uptake decreased significantly at 24 and 48 h after chemotherapy (P<0.01 and P<0.05, respectively). LI‑Ki‑67 also significantly reduced 24 and 48 h after chemotherapy (P<0.001). Furthermore, 18F‑FLT and 18F‑FDG T/M tumor uptake correlated positively with LI‑Ki‑67 before and after chemotherapy (r=0.842 and 0.813, respectively). During the early post‑chemotherapy stage, 18F‑FLT and 18F‑FDG uptake in Walker 256 tumors reduced significantly, which correlated positively with the tumor cell proliferative activity.
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Copy and paste a formatted citation
Spandidos Publications style
Xu W, Yu S, Xin J and Guo Q: 18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats. Exp Ther Med 12: 4154-4158, 2016.
APA
Xu, W., Yu, S., Xin, J., & Guo, Q. (2016). 18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats. Experimental and Therapeutic Medicine, 12, 4154-4158. https://doi.org/10.3892/etm.2016.3869
MLA
Xu, W., Yu, S., Xin, J., Guo, Q."18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats". Experimental and Therapeutic Medicine 12.6 (2016): 4154-4158.
Chicago
Xu, W., Yu, S., Xin, J., Guo, Q."18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats". Experimental and Therapeutic Medicine 12, no. 6 (2016): 4154-4158. https://doi.org/10.3892/etm.2016.3869
Copy and paste a formatted citation
x
Spandidos Publications style
Xu W, Yu S, Xin J and Guo Q: 18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats. Exp Ther Med 12: 4154-4158, 2016.
APA
Xu, W., Yu, S., Xin, J., & Guo, Q. (2016). 18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats. Experimental and Therapeutic Medicine, 12, 4154-4158. https://doi.org/10.3892/etm.2016.3869
MLA
Xu, W., Yu, S., Xin, J., Guo, Q."18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats". Experimental and Therapeutic Medicine 12.6 (2016): 4154-4158.
Chicago
Xu, W., Yu, S., Xin, J., Guo, Q."18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats". Experimental and Therapeutic Medicine 12, no. 6 (2016): 4154-4158. https://doi.org/10.3892/etm.2016.3869
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