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Article

Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis

  • Authors:
    • Yujie Ning
    • Xi Wang
    • Sen Wang
    • Xiong Guo
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 4077-4084
    |
    Published online on: November 7, 2016
       https://doi.org/10.3892/etm.2016.3879
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Abstract

The aim of the present study was to investigate the early diagnostic biomarkers of Kashin‑Beck disease (KBD), and to compare the common signaling pathways of peripheral mononuclear cells between patients with KBD and those with osteoarthritis (OA). A total of 20 and 12 peripheral blood samples were separately collected from KBD patients and normal control subjects, respectively, in an endemic area according to the diagnosis criteria. Total RNAs were extracted and gene expression levels were determined using an Agilent whole genome expression microarrays. The gene expression data of OA were obtained from GEO published database. Significant different pathways between KBD and OA were analyzed using Ingenuity Pathway Analysis software. A total of 82 differentially expressed genes, 51 significant different signaling pathways and five significant biological functions were identified in KBD patient samples, while 89, 50 and five significantly different genes, pathways and functions were identified in OA. Nine common significant pathways and five common differentially expressed genes were identified between the KBD and OA. Nine common significant pathways and five common differentially expressed genes were found between the two diseases. The present results suggest that there are similarities in vascular microcirculation, immunoreactions and cell apoptosis between KBD and OA, which may contribute to the early diagnosis and pathogenetic study of KBD.
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1 

Duan C, Guo XO, Zhang XD, Yu HJ, Yan H, Gao Y, Ma WJ, Gao ZQ, Xu P and Lammi M: Comparative analysis of gene expression profiles between primary knee osteoarthritis and an osteoarthritis endemic to northwestern china, Kashin-beck disease. Arthritis Rheum. 62:771–780. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Hinsenkamp M: Kashin-Beck disease. International Orthopaedics. 25:133. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Wang SJ, Guo X, Zuo H, Zhang YG, Xu P, Ping ZG, Zhang Z and Geng D: Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas and iNOS in articular cartilage in patients with Kashin-Beck disease. J Rheumatol. 33:615–619. 2006.PubMed/NCBI

4 

Fang H, Guo X, Farooq U, Xia C and Dong R: Development and validation of a quality of life instrument for Kashin-Beck disease: An endemic osteoarthritis in China. Osteoarthritis Cartilage. 20:630–637. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ and Lammi MJ: Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthritis Cartilage. 22:1774–1783. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Ministry of Health of the P.R China, . The standard of Medicine sanitary in P.R China-Diagnosis of Kashin-Beck disease [WS/T 207–2010]. http://www.moh.gov.cn/zwgkzt/s9500/201006/47920.shtmlAccessed June 25, 2015.

7 

Wang S, Guo X, Wu XM and Lammi MJ: Genome-wide gene expression analysis suggests an important role of suppressed immunity in pathogenesis of Kashin-Beck disease. Plos One. 7:e284392012. View Article : Google Scholar : PubMed/NCBI

8 

Ma J and Liew CC: Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. J Mol Cell Cardiol. 35:993–998. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Barnes MG, Aronow BJ, Luyrink LK, Moroldo MB, Pavlidis P, Passo MH, Grom AA, Hirsch R, Giannini EH, Colbert RA, et al: Gene expression in juvenile arthritis and spondyloarthropathy: Pro-angiogenic ELR+ chemokine genes relate to course of arthritis. Rheumatology (Oxford). 43:973–979. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Niimoto T, Nakasa T, Ishikawa M, Okuhara A, Izumi B, Deie M, Suzuki O, Adachi N and Ochi M: MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients. Bmc Musculoskeletal Disord. 11:2092010. View Article : Google Scholar

11 

Prasad NB, Somervell H, Tufano RP, Dackiw AP, Marohn MR, Califano JA, Wang Y, Westra WH, Clark DP, Umbricht CB, et al: Identification of genes differentially expressed in benign versus malignant thyroid tumors. Clinical Cancer Res. 14:3327–3337. 2008. View Article : Google Scholar

12 

Ramos YF, Bos SD, Lakenberg N, Böhringer S, den Hollander WJ, Kloppenburg M, Slagboom PE and Meulenbelt I: Genes expressed in blood link osteoarthritis with apoptotic pathways. Ann Rheum Dis. 73:1844–1853. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Wang WZ, Guo X, Duan C, Ma WJ, Zhang YG, Xu P, Gao ZQ, Wang ZF, Yan H, Zhang YF, et al: Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis. Osteoarthritis Cartilage. 17:83–90. 2009. View Article : Google Scholar : PubMed/NCBI

14 

China MoPHo China Health Statistics Yearbook. 2012.57:2013.

15 

Tusher VG, Tibshirani R and Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 98:5116–5121. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Gyrd-Hansen M and Meier P: IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer. 10:561–574. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Tan BM, Zammit NW, Yam AO, Slattery R, Walters SN, Malle E and Grey ST: Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells. Diabetologia. 56:520–532. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Rothe M, Pan MG, Henzel WJ, Ayres TM and Goeddel DV: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral-inhibitor of apoptosis proteins. Cell. 83:1243–1252. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Swirnoff AH and Milbrandt J: DNA-binding specificity of NGFI-A and related zinc-finger transcription factors. Mol Cell Biol. 15:2275–2287. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Aicher WK, Heer AH, Trabandt A, Bridges SL Jr, Schroeder HW Jr, Stransky G, Gay RE, Eibel H, Peter HH and Siebenlist U: Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid-arthritis patients. J Immunol. 152:5940–5948. 1994.PubMed/NCBI

21 

Wang FL, Connor JR, Dodds RA, James IE, Kumar S, Zou C, Lark MW, Gowen M and Nuttall ME: Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage. Osteoarthritis Cartilage. 8:161–169. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzì RM and Meliconi R: Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro. Plos One. 9:e969252014. View Article : Google Scholar : PubMed/NCBI

23 

Fernandes JC, Martel-Pelletier J and Pelletier JP: The role of cytokines in osteoarthritis pathophysiology. Biorheology. 39:237–246. 2002.PubMed/NCBI

24 

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP and Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 7:33–42. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Burguera EF, Vela-Anero A, Magalhães J, Meijide-Failde R and Blanco FJ: Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes. Osteoarthritis Cartilage. 22:1026–1035. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Borzì RM, Mazzetti I, Marcu KB and Facchini A: Chemokines in cartilage degradation. Clin Orthop Relat Res. (Suppl 427). S53–S61. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Hayden MS and Ghosh S: Shared principles in NF-kappaB signaling. Cell. 132:344–362. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Tilstra JS, Clauson CL, Niedernhofer LJ and Robbins PD: NF-kappaB in aging and disease. Aging Dis. 2:449–465. 2011.PubMed/NCBI

29 

Niedernhofer LJ and Robbins PD: Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol. 40:176–180. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Karin M, Cao Y, Greten FR and Li ZW: NF-kappaB in cancer: From innocent bystander to major culprit. Nat Rev Cancer. 2:301–310. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Beg AA, Sha WC, Bronson RT, Ghosh S and Baltimore D: Embryonic lethality and liver degeneration in mice lacking the rela component of Nf-Kappa-B. Nature. 376:167–170. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Pulai JI, Chen H, Im HJ, Kumar S, Hanning C, Hegde PS and Loeser RF: NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol. 174:5781–5788. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Nicholson DW and Thornberry NA: Caspases: Killer proteases. Trends Biochem Sci. 22:299–306. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Roach HI, Erenpreisa J and Aigner T: Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis. J Cell Biol. 131:483–494. 1995. View Article : Google Scholar : PubMed/NCBI

35 

Heraud F, Heraud A and Harmand MF: Apoptosis in normal and osteoarthritic human articular cartilage. Ann Rheum Dis. 59:959–965. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Hashimoto S, Ochs RL, Komiya S and Lotz M: Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum. 41:1632–1638. 1998. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ning Y, Wang X, Wang S and Guo X: Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis. Exp Ther Med 12: 4077-4084, 2016.
APA
Ning, Y., Wang, X., Wang, S., & Guo, X. (2016). Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis. Experimental and Therapeutic Medicine, 12, 4077-4084. https://doi.org/10.3892/etm.2016.3879
MLA
Ning, Y., Wang, X., Wang, S., Guo, X."Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis". Experimental and Therapeutic Medicine 12.6 (2016): 4077-4084.
Chicago
Ning, Y., Wang, X., Wang, S., Guo, X."Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis". Experimental and Therapeutic Medicine 12, no. 6 (2016): 4077-4084. https://doi.org/10.3892/etm.2016.3879
Copy and paste a formatted citation
x
Spandidos Publications style
Ning Y, Wang X, Wang S and Guo X: Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis. Exp Ther Med 12: 4077-4084, 2016.
APA
Ning, Y., Wang, X., Wang, S., & Guo, X. (2016). Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis. Experimental and Therapeutic Medicine, 12, 4077-4084. https://doi.org/10.3892/etm.2016.3879
MLA
Ning, Y., Wang, X., Wang, S., Guo, X."Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis". Experimental and Therapeutic Medicine 12.6 (2016): 4077-4084.
Chicago
Ning, Y., Wang, X., Wang, S., Guo, X."Comparative analysis of signaling pathways in peripheral blood from patients with Kashin‑Beck disease and osteoarthritis". Experimental and Therapeutic Medicine 12, no. 6 (2016): 4077-4084. https://doi.org/10.3892/etm.2016.3879
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