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Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture

  • Authors:
    • Yu‑Tao Peng
    • Xiang‑En Shi
    • Zhi‑Qiang Li
    • Xin He
    • Yu‑Ming Sun
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Fu Xing Hospital, Capital Medical University, Beijing 100038, P.R. China, Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100038, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3905-3912
    |
    Published online on: November 7, 2016
       https://doi.org/10.3892/etm.2016.3881
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Abstract

Particularly interesting Cys-His-rich protein (PINCH) has several biological functions in cancer development, invasion and metastasis in malignant cells, and the expression of PINCH is upregulated in several cancer types, including breast cancer, gastric adenocarcinoma and rectal cancer. However, the contribution of PINCH to human cerebral aneurysms remains largely unknown. Therefore, the significance of PINCH expression in cerebral aneurysm growth and rupture was examined in the present study. The protein expression levels of alpha‑smooth muscle actin, osteopontin (OPN), matrix metalloproteinase (MMP) 9 and PINCH were evaluated using immunohistochemistry and western blot analyses. The results demonstrate that the protein expression levels of OPN, MMP9 and PINCH in the unruptured intracranial aneurysm (UA) and ruptured intracranial aneurysm (RA) groups were markedly higher than those of the control group, whereas OPN and PINCH expression levels were decreased in the RA group compared to those of the UA group. In addition, there was a strong correlation between PINCH and tumor size (r=0.650 and P=0.0026), as well as between PINCH and OPN (r=0.639 and P=0.0033) in the unruptured cerebral aneurysms. However, the correlation between PINCH and tumor size (r=0.450 and P=0.1393) and between PINCH and OPN (r=0.366 and P=0.2426) revealed no obvious difference in the ruptured cerebral aneurysms. In conclusion, PINCH was highly expressed in the UAs, which may be a critical factor for preventing aneurysmal rupture. Moreover, PINCH may facilitate intracranial aneurysm progression, at least partially, through the activation of extracellular signal‑regulated kinase signaling and the suppression of c‑Jun N‑terminal kinase signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Peng YT, Shi XE, Li ZQ, He X and Sun YM: Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture. Exp Ther Med 12: 3905-3912, 2016.
APA
Peng, Y., Shi, X., Li, Z., He, X., & Sun, Y. (2016). Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture. Experimental and Therapeutic Medicine, 12, 3905-3912. https://doi.org/10.3892/etm.2016.3881
MLA
Peng, Y., Shi, X., Li, Z., He, X., Sun, Y."Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture". Experimental and Therapeutic Medicine 12.6 (2016): 3905-3912.
Chicago
Peng, Y., Shi, X., Li, Z., He, X., Sun, Y."Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3905-3912. https://doi.org/10.3892/etm.2016.3881
Copy and paste a formatted citation
x
Spandidos Publications style
Peng YT, Shi XE, Li ZQ, He X and Sun YM: Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture. Exp Ther Med 12: 3905-3912, 2016.
APA
Peng, Y., Shi, X., Li, Z., He, X., & Sun, Y. (2016). Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture. Experimental and Therapeutic Medicine, 12, 3905-3912. https://doi.org/10.3892/etm.2016.3881
MLA
Peng, Y., Shi, X., Li, Z., He, X., Sun, Y."Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture". Experimental and Therapeutic Medicine 12.6 (2016): 3905-3912.
Chicago
Peng, Y., Shi, X., Li, Z., He, X., Sun, Y."Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3905-3912. https://doi.org/10.3892/etm.2016.3881
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