Clinical and angiographic correlation of high‑sensitivity C‑reactive protein with acute ST elevation myocardial infarction

  • Authors:
    • Syed Tanveer
    • Shaheena Banu
    • Nasimudeen Rehumathbeevi Jabir
    • Mohd Shahnawaz Khan
    • Ghulam Md Ashraf
    • Nanjappa Cholenahally Manjunath
    • Shams Tabrez
  • View Affiliations

  • Published online on: November 8, 2016     https://doi.org/10.3892/etm.2016.3882
  • Pages: 4089-4098
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Abstract

Vascular inflammation and associated ongoing inflammatory responses are considered as the critical culprits in the pathogenesis of acute atherothrombotic events such as acute coronary syndrome (ACS) and myocardial infarction (MI). ST segment elevation myocardial infarction (STEMI) is considered as one of the prominent clinical forms of ACS. Moreover, C‑reactive protein (CRP) is an important acute phase prsotein, which may be estimated using high‑sensitivity methods (hs‑CRP), and its elevated level in body fluids reflects chronic inflammatory status. The circulating hs‑CRP level has been proposed as a promising inflammatory marker of coronary artery disease (CAD). The present study investigated the correlation of hs‑CRP level with clinical and angiographic features of STEMI, various other traditional risk factors, complications of myocardial infarction and angiographically significant CAD. Out of 190 patients with STEMI that were analyzed, the interval between symptom onset and reperfusion therapy (window period) varied from 0.5 to 24 h. The hs‑CRP value was found to be higher in non‑diabetic patients (0.61 mg/dl) compared with diabetic patients (0.87 mg/dl). Moreover, a significant correlation between hs‑CRP and hs‑troponin T was also recorded (P<0.001). However, there was no significant difference in the mean hs‑CRP values in patients with or without mortality. It is considered that the present study will increase the understanding of atherosclerosis in general and may also have clinical applications in the targeting of therapy for this harmful disease.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tanveer S, Banu S, Jabir NR, Khan MS, Ashraf GM, Manjunath NC and Tabrez S: Clinical and angiographic correlation of high‑sensitivity C‑reactive protein with acute ST elevation myocardial infarction. Exp Ther Med 12: 4089-4098, 2016
APA
Tanveer, S., Banu, S., Jabir, N.R., Khan, M.S., Ashraf, G.M., Manjunath, N.C., & Tabrez, S. (2016). Clinical and angiographic correlation of high‑sensitivity C‑reactive protein with acute ST elevation myocardial infarction. Experimental and Therapeutic Medicine, 12, 4089-4098. https://doi.org/10.3892/etm.2016.3882
MLA
Tanveer, S., Banu, S., Jabir, N. R., Khan, M. S., Ashraf, G. M., Manjunath, N. C., Tabrez, S."Clinical and angiographic correlation of high‑sensitivity C‑reactive protein with acute ST elevation myocardial infarction". Experimental and Therapeutic Medicine 12.6 (2016): 4089-4098.
Chicago
Tanveer, S., Banu, S., Jabir, N. R., Khan, M. S., Ashraf, G. M., Manjunath, N. C., Tabrez, S."Clinical and angiographic correlation of high‑sensitivity C‑reactive protein with acute ST elevation myocardial infarction". Experimental and Therapeutic Medicine 12, no. 6 (2016): 4089-4098. https://doi.org/10.3892/etm.2016.3882