Open Access

miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2

  • Authors:
    • Sifeng Tang
    • Deyou Wang
    • Qiwen Zhang
    • Leping Li
  • View Affiliations

  • Published online on: November 11, 2016     https://doi.org/10.3892/etm.2016.3893
  • Pages: 3837-3842
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Novel targeted therapies need to be developed for gastric cancer, the third most common cancer type and the second most common cause of cancer‑related mortality in China. Previous studies indicate that angiopoietin (Ang)-2 serves a role in the proliferation, migration, invasion and adhesion of malignant cells. The present study identified, using functional studies, that exogenous expression of miR‑218 increased migration of NCI‑87 and HGC‑27 gastric cancer cells, which coincided with a reduction in the expression of Ang‑2. In addition, intratumoral delivery of miR-218 inhibited proliferation and angiogenesis of gastric cancer cells in vivo, with a corresponding decreased in Ang‑2 expression. These results indicate that miR‑218 serves an important role in gastric cancer tumorigenesis through regulating the expression of Ang-2. Therefore, components of miR-218/Ang-2 signaling could provide novel therapeutic targets for the treatment of gastric cancer.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Tang S, Wang D, Zhang Q and Li L: miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2. Exp Ther Med 12: 3837-3842, 2016
APA
Tang, S., Wang, D., Zhang, Q., & Li, L. (2016). miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2. Experimental and Therapeutic Medicine, 12, 3837-3842. https://doi.org/10.3892/etm.2016.3893
MLA
Tang, S., Wang, D., Zhang, Q., Li, L."miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2". Experimental and Therapeutic Medicine 12.6 (2016): 3837-3842.
Chicago
Tang, S., Wang, D., Zhang, Q., Li, L."miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3837-3842. https://doi.org/10.3892/etm.2016.3893