Conservative pharmacotherapy vs. staged percutaneous coronary intervention for non-culprit vessels in patients with ST-segment elevation myocardial infarction

  • Authors:
    • Bo Zhao
    • Jianjun Peng
    • Lihui Ren
    • Licheng Lei
    • Zuoyan Wang
    • Huiming Ye
  • View Affiliations

  • Published online on: November 14, 2016     https://doi.org/10.3892/etm.2016.3895
  • Pages: 4147-4153
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Abstract

The present study aimed to compare the effect of conservative pharmacotherapy (CP) and staged percutaneous coronary intervention (SPCI) on significant non-culprit vessels in patients with ST‑segment elevation myocardial infarction (STEMI). A total of 266 male and 40 female patients were divided into two groups following their first successful PCI treatment: i) Patients in the complete revascularization (CR) group undergoing SPCI; and ii) patients in the CP group undergoing CP. Follow‑up data were collected at 180 or 360 days after surgery to compare the rates of major adverse cardiovascular events (MACE), recurrent myocardial infarction, recurrent angina pectoris and MACE‑free survival rates between the two groups. The rate of MACE in the CP group was higher compared with that in the CR group at the 360-day follow‑up (6.1 vs. 12.7%; P=0.05), and the same was reflected in the rate of recurrent myocardial infarction (10.1 vs. 4.1%; P=0.04). The rate of recurrent angina pectoris in the CP group was significantly higher compared with that in CR group at the 180‑day (13.9 vs. 5.4%; P=0.012) and 360‑day follow‑up (18.4 vs. 8.1%; P=0.009). The MACE‑free survival rate of patients was significantly higher in the CR group compared with that in the CP group at the 360‑day follow‑up (93.9% vs. 87.3%, P<0.05). In conclusion, the SPCI of non-culprit vessels in patients with STEMI is associated with better clinical outcomes than CP.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhao B, Peng J, Ren L, Lei L, Wang Z and Ye H: Conservative pharmacotherapy vs. staged percutaneous coronary intervention for non-culprit vessels in patients with ST-segment elevation myocardial infarction . Exp Ther Med 12: 4147-4153, 2016
APA
Zhao, B., Peng, J., Ren, L., Lei, L., Wang, Z., & Ye, H. (2016). Conservative pharmacotherapy vs. staged percutaneous coronary intervention for non-culprit vessels in patients with ST-segment elevation myocardial infarction . Experimental and Therapeutic Medicine, 12, 4147-4153. https://doi.org/10.3892/etm.2016.3895
MLA
Zhao, B., Peng, J., Ren, L., Lei, L., Wang, Z., Ye, H."Conservative pharmacotherapy vs. staged percutaneous coronary intervention for non-culprit vessels in patients with ST-segment elevation myocardial infarction ". Experimental and Therapeutic Medicine 12.6 (2016): 4147-4153.
Chicago
Zhao, B., Peng, J., Ren, L., Lei, L., Wang, Z., Ye, H."Conservative pharmacotherapy vs. staged percutaneous coronary intervention for non-culprit vessels in patients with ST-segment elevation myocardial infarction ". Experimental and Therapeutic Medicine 12, no. 6 (2016): 4147-4153. https://doi.org/10.3892/etm.2016.3895