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Article

D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study

  • Authors:
    • Yun Li
    • Xingshun Qi
    • Hongyu Li
    • Junna Dai
    • Han Deng
    • Jing Li
    • Ying Peng
    • Xu Liu
    • Xiaolin Sun
    • Xiaozhong Guo
  • View Affiliations / Copyright

    Affiliations: Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning 110840, P.R. China
  • Pages: 285-289
    |
    Published online on: November 28, 2016
       https://doi.org/10.3892/etm.2016.3930
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Abstract

The present study aimed to examine the correlation of D-dimer levels with the Child-Pugh and MELD scores, as well as to determine the predictive ability of D-dimer level for the in-hospital mortality of liver cirrhosis patients. All cirrhotic patients who were consecutively admitted to our hospital between January 2011 and June 2014, and underwent D‑dimer tests on admission were retrospectively analyzed. Pearson's χ2 tests were employed to evaluate the correlations of D‑dimer levels with Child‑Pugh and MELD scores. In addition, receiver operating curve (ROC) analysis was employed to evaluate the specificity and sensitivity of D‑dimer levels for predicting the in‑hospital mortality. In total, 703 cirrhotic patients were included in the study, with an in‑hospital mortality of 5.4% (38/703). The D‑dimer levels were correlated with Child-Pugh (correlation coefficient, 0.219; P<0.001) and MELD scores (correlation coefficient, 0.207; P<0.001). The highest D‑dimer level was observed in the Child‑Pugh class C patients, followed by the class B and A patients. Furthermore, D‑dimer was significantly higher in the MELD score >15 group compared with the MELD score <15 group. The area under the ROC of D‑dimer levels for predicting the in‑hospital mortality of liver cirrhosis was 0.729 (P<0.0001), while the best cut‑off D‑dimer value was 0.28 µg/ml with a sensitivity of 86.84% and a specificity of 49.17%. In conclusion, the D-dimer level is significantly associated with the degree of liver dysfunction. Therefore, D-dimer testing could be employed for the prognostic stratification of liver cirrhosis.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Qi X, Li H, Dai J, Deng H, Li J, Peng Y, Liu X, Sun X, Guo X, Guo X, et al: D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study. Exp Ther Med 13: 285-289, 2017.
APA
Li, Y., Qi, X., Li, H., Dai, J., Deng, H., Li, J. ... Guo, X. (2017). D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study. Experimental and Therapeutic Medicine, 13, 285-289. https://doi.org/10.3892/etm.2016.3930
MLA
Li, Y., Qi, X., Li, H., Dai, J., Deng, H., Li, J., Peng, Y., Liu, X., Sun, X., Guo, X."D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study". Experimental and Therapeutic Medicine 13.1 (2017): 285-289.
Chicago
Li, Y., Qi, X., Li, H., Dai, J., Deng, H., Li, J., Peng, Y., Liu, X., Sun, X., Guo, X."D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study". Experimental and Therapeutic Medicine 13, no. 1 (2017): 285-289. https://doi.org/10.3892/etm.2016.3930
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Qi X, Li H, Dai J, Deng H, Li J, Peng Y, Liu X, Sun X, Guo X, Guo X, et al: D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study. Exp Ther Med 13: 285-289, 2017.
APA
Li, Y., Qi, X., Li, H., Dai, J., Deng, H., Li, J. ... Guo, X. (2017). D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study. Experimental and Therapeutic Medicine, 13, 285-289. https://doi.org/10.3892/etm.2016.3930
MLA
Li, Y., Qi, X., Li, H., Dai, J., Deng, H., Li, J., Peng, Y., Liu, X., Sun, X., Guo, X."D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study". Experimental and Therapeutic Medicine 13.1 (2017): 285-289.
Chicago
Li, Y., Qi, X., Li, H., Dai, J., Deng, H., Li, J., Peng, Y., Liu, X., Sun, X., Guo, X."D-dimer level for predicting the in-hospital mortality in liver cirrhosis: A retrospective study". Experimental and Therapeutic Medicine 13, no. 1 (2017): 285-289. https://doi.org/10.3892/etm.2016.3930
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