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Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke

  • Authors:
    • Jian Li
    • Yong Zhao
    • Jinying Mao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Neurology Division, Weifang People's Hospital, Weifang, Shangdong 261041, P.R. China, The Second Department of Cardiology, Weifang People's Hospital, Weifang, Shangdong 261041, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 909-912
    |
    Published online on: January 11, 2017
       https://doi.org/10.3892/etm.2017.4035
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Abstract

White matter (WM) injury following acute ischemic stroke (AIS) is associated with cognitive decline. Establishing relationships between the specific cognitive tests used to assess post-AIS cognition and various clinical indices of WM injury severity and distribution may aid in prognosis and early treatment decisions. We enrolled 62 patients with AIS to Weifang People's Hospital between September 2014 and August 2015. WM lesion severity and distribution were examined by computed tomography (CT) and magnetic resonance imaging (MRI). The Blennow scale was used for scoring the distribution and degree of WM lesions (WMLs) on CT images, the Fazekas scale for scoring periventricular and deep WMLs on MRI, and the Cholinergic Pathways Hyperintensities Scale (CHIPS) for scoring MRI manifestation of cholinergic fiber damage. The 8-domain Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive function. Mean ± standard deviation scores on the Blennow scale was 1.6±0.5; Fazekas scale, 3.4±0.8; and CHIPS, 65.7±12.5. The proportion of patients with a MoCA score <26 (indicating cognitive dysfunction) was significantly higher in subgroups with Blennow scale score >2, Fazekas scale score >4, and CHIPS score >51 (all P<0.001). The MoCA score was negatively correlated with Blennow scale score (r=-0.326, P=0.002), Fazekas scale score (r=-0.404, P=0.031), and CHIPS score (r=-0.234, P=0.042). Thus, the degree and distribution of whole-brain, deep, and cholinergic WMLs were associated with cognitive impairment. The Blennow scale, Fazekas scale, and CHIPS all provide good predictive efficacy of post-AIS cognitive dysfunction.
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1 

Huang Q, Song HQ, Ji XM, Cheng WY, Feng J, Wu J and Ma QF: Generalization of the right acute stroke prevention strategies in reducing in-hospital delays. PLoS One. 11:e01549722016. View Article : Google Scholar : PubMed/NCBI

2 

Leonards CO, Ipsen N, Malzahn U, Fiebach JB, Endres M and Ebinger M: White matter lesion severity in mild acute ischemic stroke patients and functional outcome after 1 year. Stroke. 43:3046–3051. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Liao J, Zhu Y, Zhang M, Yuan H, Su MY, Yu X and Wang H: Microstructural white matter abnormalities independent of white matter lesion burden in amnestic mild cognitive impairment and early Alzheimer disease among Han Chinese elderly. Alzheimer Dis Assoc Disord. 24:317–324. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Curtze S, Melkas S, Sibolt G, Haapaniemi E, Mustanoja S, Putaala J, Sairanen T, Tiainen M, Tatlisumak T and Strbian D: Cerebral computed tomography-graded white matter lesions are associated with worse outcome after thrombolysis in patients with stroke. Stroke. 46:1554–1560. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Maier O, Wilms M, von der Gablentz J, Krämer UM, Münte TF and Handels H: Extra tree forests for sub-acute ischemic stroke lesion segmentation in MR sequences. J Neurosci Methods. 240:89–100. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Behl P, Bocti C, Swartz RH, Gao F, Sahlas DJ, Lanctot KL, Streiner DL and Black SE: Strategic subcortical hyperintensities in cholinergic pathways and executive function decline in treated Alzheimer patients. Arch Neurol. 64:266–272. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Fern RF, Matute C and Stys PK: White matter injury: ischemic and nonischemic. Glia. 62:1780–1789. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Yamano S, Horii M, Takami T, Sakuma M, Morimoto T, Okada S, Taoka T, Kichikawa K, Sasamura H, Itoh H, et al: Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of stroke recurrence and longitudinal progression of white matter lesions and silent brain infarcts on MRI (CEREBRAL study): rationale, design, and methodology. Int J Stroke. 10:452–456. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Bolandzadeh N, Davis JC, Tam R, Handy TC and Liu-Ambrose T: The association between cognitive function and white matter lesion location in older adults: a systematic review. BMC Neurol. 12:1262012. View Article : Google Scholar : PubMed/NCBI

10 

Yan T, Yu JR, Zhang YP and Li T: Analysis on correlation of white matter lesion and lacunar infarction with vascular cognitive impairment. Int J Clin Exp Med. 8:14119–14122. 2015.PubMed/NCBI

11 

Tu Q, Ding B, Yang X, Bai S, Tu J, Liu X, Wang R, Tao J, Jin H, Wang Y, et al: The current situation on vascular cognitive impairment after ischemic stroke in Changsha. Arch Gerontol Geriatr. 58:236–247. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Li L, Simoni M, Küker W, Schulz UG, Christie S, Wilcock GK and Rothwell PM: Population-based case-control study of white matter changes on brain imaging in transient ischemic attack and ischemic stroke. Stroke. 44:3063–3070. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Boutet C, Rouffiange-Leclair L, Schneider F, Camdessanché JP, Antoine JC and Barral FG: Visual assessment of age-related white matter hyperintensities using FLAIR images at 3 T: inter- and intra-rater agreement. Neurodegener Dis. 16:279–283. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Obara T, Hasegawa H, Wachi Y, Tanaka M, Sato M, Kobayashi Y, Koshiba H, Nagai K, Yamada Y, Matsui T, et al: The characteristics of a comprehensive geriatric assessment in patients with mild cognitive impairment with a cerebral white matter lesion. Nippon Ronen Igakkai Zasshi. 52:399–410. 2015.(In Japanese). View Article : Google Scholar : PubMed/NCBI

15 

Helenius J, Goddeau RP Jr, Moonis M and Henninger N: Impact of leukoaraiosis burden on hemispheric lateralization of the National Institutes of Health Stroke Scale Deficit in acute ischemic stroke. Stroke. 47:24–30. 2016. View Article : Google Scholar : PubMed/NCBI

16 

McNeely AA, Ramirez J, Nestor SM, Zhao J, Gao F, Kiss A, Stuss DT and Black SE: Cholinergic subcortical hyperintensities in Alzheimer's disease patients from the Sunnybrook Dementia Study: relationships with cognitive dysfunction and hippocampal atrophy. J Alzheimers Dis. 43:785–796. 2015.PubMed/NCBI

17 

Mi T, Qu CQ, Wang X, Sun QJ, Sun H and Du YF: Characteristics of cognitive impairment of different infarct locations among patients after acute ischemic stroke. Zhonghua Yi Xue Za Zhi. 96:1205–1207. 2016.(In Chinese). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Zhao Y and Mao J: Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke. Exp Ther Med 13: 909-912, 2017.
APA
Li, J., Zhao, Y., & Mao, J. (2017). Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke. Experimental and Therapeutic Medicine, 13, 909-912. https://doi.org/10.3892/etm.2017.4035
MLA
Li, J., Zhao, Y., Mao, J."Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke". Experimental and Therapeutic Medicine 13.3 (2017): 909-912.
Chicago
Li, J., Zhao, Y., Mao, J."Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke". Experimental and Therapeutic Medicine 13, no. 3 (2017): 909-912. https://doi.org/10.3892/etm.2017.4035
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Zhao Y and Mao J: Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke. Exp Ther Med 13: 909-912, 2017.
APA
Li, J., Zhao, Y., & Mao, J. (2017). Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke. Experimental and Therapeutic Medicine, 13, 909-912. https://doi.org/10.3892/etm.2017.4035
MLA
Li, J., Zhao, Y., Mao, J."Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke". Experimental and Therapeutic Medicine 13.3 (2017): 909-912.
Chicago
Li, J., Zhao, Y., Mao, J."Association between the extent of white matter damage and early cognitive impairment following acute ischemic stroke". Experimental and Therapeutic Medicine 13, no. 3 (2017): 909-912. https://doi.org/10.3892/etm.2017.4035
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