Preventative effects of fermented Chimonobambusa quadrangularis shoot on activated carbon‑induced constipation

Li,Guijie; Zou,Xiaochuan; Kuang,Gang; Ren,Yanrong; Deng,Chaofang; Lin,Qiang; Zhao,Xin; Xu,Song; Song,Jia‑Le

doi:10.3892/etm.2017.4036

Preventative effects of fermented Chimonobambusa quadrangularis shoot on activated carbon‑induced constipation

Authors:
- Guijie Li
- Xiaochuan Zou
- Gang Kuang
- Yanrong Ren
- Chaofang Deng
- Qiang Lin
- Xin Zhao
- Song Xu
- Jia‑Le Song
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Affiliations: Chongqing Collaborative Innovation Center for Functional Food, Chongqing 400067, P.R. China, Chongqing Xuerui Shengquan Agricultural Development Co., Ltd., Chongqing 400802, P.R. China
Published online on: January 11, 2017 https://doi.org/10.3892/etm.2017.4036
Pages: 1093-1100

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Abstract

The present study aimed to determine the preventative effects of fermented Chimonobambusa quadrangularis shoot (FCQS) on activated carbon constipation in Kun Ming mice. FCQS has a more loose fiber tissue structure than unfermented fresh C. quadrangularis shoot (CQS), which is preferable for relieving constipation. In mice fed with FCQS for 9 days the time from consumption to their first black stool defecation (117 min) was shorter than the control group (192 min) and the CQS group (148 min); however, it was longer than the normal (85 min) and bisacodyl treatment (99 min) groups. The gastrointestinal transit of the FCQS group (73.8%) was increased, as compared with the control (37.9%) and CQS (61.7%) groups; however, it was decreased as compared with the normal (100%) and bisacodyl (88.3%) groups. By observing the hemotoxylin and eosin‑stained section of mice intestine, it was demonstrated that FCQS reduced injury to the intestinal tract resulting from constipation and alleviated the damage caused to the intestinal villi over the effects observed in the CQS group. Furthermore, FCQS was also able to increase the serum levels of motilin, endothelin‑1, vasoactive intestinal peptide and acetylcholinesterase compared with the control group. c‑Kit, stem cell factor (SCF), glial cell‑derived neurotrophic factor (GDNF) mRNA and protein expression levels in the small intestinal cells of FCQS‑fed mice were increased, as compared with CQS‑fed mice. Transient receptor potential cation channel subfamily V member 1 (TRPV1) and nitric oxide synthase (NOS) expression levels of small intestinal cells of FCQS‑fed mice were reduced, as compared with CQS‑fed mice. These findings demonstrated that FCQS may induce improved preventative effects on constipation, compared with CQS.

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1	Li R, Wu LR and Zhou CP: A study on the mineral nutrition composition of Chimonobambusa quadrangularis bamboo shoots. J Bamboo Res. 26:37–39. 2007.
2	Feng HY, Li M and Ma YH: Technology of harvesting processing on Chimonobambusa utilis (Keng) Keng f. World Bamboo Rattan. 14:27–28. 2006.
3	Zhang RG, Li M, Wang XQ and Liu LC: Preliminary study of the forming of special quality of Chimonobambusa utilis bamboo shoot in Nanchuan, Chongqing. World Bamboo Rattan. 8:30–33. 2010.
4	Li AP, Xie BX, Tian YF and Gu ML: Effect of fermentation on anti-nutritional factor contents and adsorption of dietary fiber for Ca²⁺, Mg²⁺, Pb²⁺. Food Sci Technol (Campinas). 35:96–99. 2010.
5	Hsu HH, Leung WH and Hu GC: Treatment of irritable bowel syndrome with a novel colonic irrigation system: A pilot study. Tech Coloproctol. 20:551–557. 2016. View Article : Google Scholar : PubMed/NCBI
6	Christer R, Robinson L and Bird C: Constipation: Causes and cures. Nurs Times. 99:26–27. 2003.PubMed/NCBI
7	Liu W, Liu XH, Fang XC, Zhou LK, Yang XL, Ke MY, Zhao HC, Zhang M, Xie PY, Hao JY, et al: A multicenter epidemiological investigation on outpatients with chronic constipation in Beijing area. Clin J Gastroenterol. 15:95–98. 2010.
8	Zhou HJ, Zhang QS, Shi L, Li H, Xu JY, Huang CY, Chen G and Li M: Effect of direct vat set Lactobacillus on intestinal function in mice with constipation. Food Ferment Technol. 49:26–29. 2003.
9	Wang Y, Cai DL, Yuan JY, Zhang YZ, Zhou JH and Li HQ: Effect of dietary fibers on patient with functional constipation. Wu Jing Yi Xue. 25:13–15. 2014.(In Chinese).
10	Jiang NQ, Xie BX, He G, Li AP and Xie T: Studies on intestinal peristalsis induced by fermenting bamboo-shoots dietary fiber. Acta Nutr Sinica. 24:439–440. 2002.
11	Qian Y, Zhao X and Kan J: Preventive effect of resistant starch on activated carbon-induced constipation in mice. Exp Ther Med. 6:228–232. 2013.PubMed/NCBI
12	Li G, Wang Q, Qian Y, Zhou Y, Wang R and Zhao X: Component analysis of Pu-erh and its anti-constipation effects. Mol Med Rep. 9:2003–2009. 2014.PubMed/NCBI
13	Li GJ, Qian Y, Sun P, Feng X, Zhu K and Zhao X: Preventive effect of polysaccharide of Larimichthys Crocea swimming bladder on activated carbon-induced constipation in mice. J Korean Soc Appl Biol Chem. 57:167–172. 2014. View Article : Google Scholar
14	Chen LH, Song JL, Qian Y, Zhao X, Suo HY and Li J: Increased preventive effect on colon carcinogenesis by use of resistant starch (RS3) as the carrier for polysaccharide of Larimichthys crocea swimming bladder. Int J Mol Sci. 15:817–829. 2014. View Article : Google Scholar : PubMed/NCBI
15	Zhao X, Wang Q, Li GJ, Chen F, Qian Y and Wang R: In vitro antioxidant, anti-mutagenic, anti-cancer and anti-angiogenic effects of Chinese Bowl tea. J Funct Food. 7:590–598. 2014. View Article : Google Scholar
16	Zhao X, Suo HY, Qian Y, Li GJ, Liu ZH and Li J: Therapeutic effects of Lactobacillus casei Qian treatment in activated carbon-induced constipated mice. Mol Med Rep. 12:3191–3199. 2015.PubMed/NCBI
17	Wu LR, Gao GB, Bai RH, Shao Q and Li R: Research and application of dietary fiber from bamboo shoots. J Bamboo Res. 29:1–5+33. 2010.
18	Whitehead WE, Palsson OS and Simrén M: Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation. Neurogastroenterol Motil. 28:783–792. 2016. View Article : Google Scholar : PubMed/NCBI
19	Qian Y, Suo H, Du M, Zhao X, Li J, Li GJ, Song JL and Liu Z: Preventive effect of Lactobacillus fermentum Lee on activated carbon-induced constipation in mice. Exp Ther Med. 9:272–278. 2015.PubMed/NCBI
20	Liu Y, Zhao XR, Wang R, Qiu GQ and Zhang M: Effect of Zhizhuwan on gastrointestinal peptide concentrations in plasma of diabetic gastroenteropathy with constipation patients. Zhongguo Zhong Yao Za Zhi. 33:2966–2968. 2008.(In Chinese). PubMed/NCBI
21	Zhao X, Qian Y, Suo HY, Du MY, Li GJ, Liu ZH, et al: Preventive effect of Lactobacillus fermentum Zhao on activated carbon-induced constipation in mice. J Nutr Sci Vitaminol. 61:131–137. 2015. View Article : Google Scholar : PubMed/NCBI
22	Song HL, Tian FS, Qiao P and Duan HB: Effects of Sanhuang tablet on plasma ET and NO levels in patients with diabetic constipation. Chinese J Tradit Med Sci Technol. 17:285–286. 2010.
23	King SK, Sutcliffe JR, Ong SY, Lee M, Koh TL, Wong SQ, Farmer PJ, Peck CJ, Stanton MP, Keck J, et al: Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow-transit constipation. Neurogastroenterol Motil. 22:883–892. 2010. View Article : Google Scholar : PubMed/NCBI
24	Suo H, Zhao X, Qian Y, Li G, Liu Z, Xie J and Li J: Therapeutic effect of activated carbon-induced constipation mice with Lactobacillus fermentum Suo on treatment. Int J Mol Sci. 15:21875–21895. 2014. View Article : Google Scholar : PubMed/NCBI
25	Brading AF and McCloskey KD: Mechanisms of disease: Specialized interstitial cells of the urinary tract-An assessment of current knowledge. Nat Clin Pract Urol. 2:546–554. 2005. View Article : Google Scholar : PubMed/NCBI
26	Geppetti P and Trevisani M: Activation and sensitisation of the vanilloid receptor: Role in gastrointestinal inflammation and function. Br J Pharmacol. 141:1313–1320. 2004. View Article : Google Scholar : PubMed/NCBI
27	Xu GP, Fan YH and Lv B: Advances in understanding the role of neurotrophins in physiological and pathological processes in the intestinal tract. World Chinese J Digestol. 18:2884–2888. 2010.
28	Tomita R, Igarashi S, Fujisaki S and Tanjoh K: The effects of neurotensin in the colon of patients with slow transit constipation. Hepatogastroenterology. 54:1662–1666. 2007.PubMed/NCBI