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Article

α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage

  • Authors:
    • Yong Zhu
    • Fangfang Bi
    • Yanchun Li
    • Huiming Yin
    • Na Deng
    • Haiquan Pan
    • Dongfang Li
    • Bo Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Affiliated Hospital of Hunan University of Medicine, Huaihua, Hunan 418000, P.R. China, Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Respiration, The First Affiliated Hospital of Hunan University of Medicine, Huaihua, Hunan 418000, P.R. China
  • Pages: 1143-1150
    |
    Published online on: January 13, 2017
       https://doi.org/10.3892/etm.2017.4045
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Abstract

Previous studies have demonstrated an association between neurological diseases and oxidative stress (OS). Naphthoflavone is a synthetic derivative of naturally occurring flavonoids that serves an important role in the treatment and prevention of OS‑related diseases. The current study was designed to apply α‑ and β‑Naphthoflavone individually and in combination to counteract the detrimental effects of OS on neurons in vitro. Neuronal SH‑SY5Y cells were subjected to 20 µM H2O2, followed by exposure to 20 µM α‑Naphthoflavone and/or 10 µM β‑Naphthoflavone. Results indicated that α‑ and β‑Naphthoflavone effectively antagonized the apoptosis‑promoting effect of H2O2 on neuronal SH‑SY5Y cells, and that β‑Naphthoflavone significantly (P<0.05) reversed H2O2‑inhibited cell viability. Notably, co‑treatment of α‑ and β‑Naphthoflavone reversed the H2O2‑induced apoptosis rate elevation and cell viability reduction. Further analysis demonstrated that H2O2 inhibited the activities of antioxidant enzymes including catalase, superoxide dismutase and glutathione peroxidase, but this was reversed by the co‑treatment with α‑ and β‑Naphthoflavone and selectively enhanced by the treatment with α‑ or β‑Naphthoflavone. H2O2‑stimulated p38 mitogen‑activated protein kinase activation was repressed following treatment with α‑ and/or β‑Naphthoflavone, along with a decreased expression of the apoptosis‑related factors and inhibited caspase‑3 activation. In conclusion, co‑treatment with α‑ and β‑Naphthoflavone minimized H2O2‑led neuron damage compared with treatment with α‑ or β‑Naphthoflavone, suggesting a synergetic effect between α‑ and β‑Naphthoflavone. This indicates that utilizing α‑ and β‑Naphthoflavone together in the clinical setting may provide a novel therapeutic for neurological disease.
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1 

Weaver J and Liu KJ: Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature. Med Gas Res. 5:112015. View Article : Google Scholar : PubMed/NCBI

2 

Amara F, Berbenni M, Fragni M, Leoni G, Viggiani S, Ippolito VM, Larocca M, Rossano R, Alberghina L, Riccio P and Colangelo AM: Neuroprotection by cocktails of dietary antioxidants under conditions of nerve growth factor deprivation. Oxid Med Cell Longev. 2015:2172582015. View Article : Google Scholar : PubMed/NCBI

3 

Choong CJ and Say YH: Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K. Neurotoxicology. 32:857–863. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Tchantchou F, Graves M, Ortiz D, Rogers E and Shea TB: Dietary supplementation with apple juice concentrate alleviates the compensatory increase in glutathione synthase transcription and activity that accompanies dietary- and genetically-induced oxidative stress. J Nutr Health Aging. 8:492–496. 2004.PubMed/NCBI

5 

Villegas-Rivera G, Román-Pintos LM, Cardona-Muñoz EG, Arias-Carvajal O, Rodríguez-Carrizalez AD, Troyo-Sanromán R, Pacheco-Moisés FP, Moreno-Ulloa A and Miranda-Díaz AG: Effects of ezetimibe/simvastatin and rosuvastatin on oxidative stress in diabetic neuropathy: A randomized, double-blind, placebo-controlled clinical trial. Oxid Med Cell Longev. 2015:7562942015. View Article : Google Scholar : PubMed/NCBI

6 

Yang T, Li X, Zhu W, Chen C, Sun Z, Tan Z and Kang J: Alteration of antioxidant enzymes and associated genes induced by grape seed extracts in the primary muscle cells of goats in vitro. PLoS One. 9:e1076702014. View Article : Google Scholar : PubMed/NCBI

7 

Soundararajan R, Wishart AD, Rupasinghe HP, Arcellana-Panlilio M, Nelson CM, Mayne M and Robertson GS: Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. J Biol Chem. 283:2231–2245. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Xu XH, Li GL, Wang BA, Qin Y, Bai SR, Rong J, Deng T and Li Q: Diallyl trisufide protects against oxygen glucose deprivation-induced apoptosis by scavenging free radicals via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway in B35 neural cells. Brain Res. 1614:38–50. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Wang Z, Ji C, Wu L, Qiu J, Li Q, Shao Z and Chen G: Tert-butylhydroquinone alleviates early brain injury and cognitive dysfunction after experimental subarachnoid hemorrhage: Role of Keap1/Nrf2/ARE pathway. PLoS One. 9:e976852014. View Article : Google Scholar : PubMed/NCBI

10 

Singh N, Agrawal M and Doré S: Neuroprotective properties and mechanisms of resveratrol in vitro and in vivo experimental cerebral stroke models. ACS Chem Neurosci. 4:1151–1162. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Bournival J, Plouffe M, Renaud J, Provencher C and Martinoli MG: Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system. Oxid Med Cell Longev. 2012:9219412012. View Article : Google Scholar : PubMed/NCBI

12 

Mena MA, Casarejos MJ, Solano R, Rodríguez-Navarro JA, Gómez A, Rodal I, Medina M and de Yebenes JG: NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice. FEBS Lett. 583:168–174. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Jazvinšćak Jembrek M, Hof PR and Šimić G: Ceramides in Alzheimer's disease: Key mediators of neuronal apoptosis induced by oxidative stress and Aβ accumulation. Oxid Med Cell Longev. 2015:3467832015. View Article : Google Scholar : PubMed/NCBI

14 

Leonardo CC and Doré S: Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins. Nutr Neurosci. 14:226–236. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Lin WL, Wang SM, Ho YJ, Kuo HC, Lee YJ and Tseng TH: Ethyl acetate extract of Wedelia chinensis inhibits tert-butyl hydroperoxide-induced damage in PC12 cells and D-galactose-induced neuronal cell loss in mice. BMC Complement Altern Med. 14:4912014. View Article : Google Scholar : PubMed/NCBI

16 

Zhu A, Wu Z, Meng J, McGeer PL, Zhu Y, Nakanishi H and Wu S: The neuroprotective effects of ratanasampil on oxidative stress-mediated neuronal damage in human neuronal SH-SY5Y cells. Oxid Med Cell Longev. 2015:7923422015. View Article : Google Scholar : PubMed/NCBI

17 

Dhawan K: Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.-a brief perspective. Addict Biol. 8:379–386. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Hu Q, Yu J, Yang W, Kimatu BM, Fang Y, Ma N and Pei F: Identification of flavonoids from Flammulina velutipes and its neuroprotective effect on pheochromocytoma-12 cells. Food Chem. 204:274–282. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Nannelli A, Rossignolo F, Tolando R, Rossato P, Longo V and Gervasi PG: Effect of beta-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig. Toxicology. 265:69–79. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Morrissy S, Strom J, Purdom-Dickinson S and Chen QM: NAD(P)H: Quinone oxidoreductase 1 is induced by progesterone in cardiomyocytes. Cardiovasc Toxicol. 12:108–114. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Higgins LG and Hayes JD: Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents. Drug Metab Rev. 43:92–137. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Reed JR, Cawley GF and Backes WL: Inhibition of cytochrome P450 1A2-mediated metabolism and production of reactive oxygen species by heme oxygenase-1 in rat liver microsomes. Drug Metab Lett. 5:6–16. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Hsu SY, Liou JW, Cheng TL, Peng SY, Lin CC, Chu YY, Luo WC, Huang ZK and Jiang SJ: Beta-Naphthoflavone protects from peritonitis by reducing TNF-alpha-induced endothelial cell activation. Pharmacol Res. 102:192–199. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Milardovic S, Kereković I, Derrico R and Rumenjak V: A novel method for flow injection analysis of total antioxidant capacity using enzymatically produced ABTS*+ and biamperometric detector containing interdigitated electrode. Talanta. 71:213–220. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Tsikas D: Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Anal Biochem. Oct 24–2016.(Epub ahead of print). View Article : Google Scholar

26 

Park HR, Lee H, Park H, Jeon JW, Cho WK and Ma JY: Neuroprotective effects of Liriope platyphylla extract against hydrogen peroxide-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. BMC Complement Altern Med. 15:1712015. View Article : Google Scholar : PubMed/NCBI

27 

Liao PL, Li CH, Chang CY, Lu SR, Lin CH, Tse LS and Cheng YW: Anti-ageing effects of alpha-naphthoflavone on normal and UVB-irradiated human skin fibroblasts. Exp Dermatol. 21:546–548. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Mense SM, Singh B, Remotti F, Liu X and Bhat HK: Vitamin C and alpha-naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female ACI rats. Carcinogenesis. 30:1202–1208. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Xiao Y, Xue X, Wu YF, Xin GZ, Qian Y, Xie TP, Gong LK and Ren J: Beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta Pharmacol Sin. 30:1559–1565. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Sinha A, Muthiah K, Jiang W, Couroucli X, Barrios R and Moorthy B: Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone. Toxicol Sci. 87:204–212. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Kober SL, Meyer-Alert H, Grienitz D, Hollert H and Frohme M: Intact cell mass spectrometry as a rapid and specific tool for the differentiation of toxic effects in cell-based ecotoxicological test systems. Anal Bioanal Chem. 407:7721–7731. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Csepregi K, Neugart S, Schreiner M and Hideg É: Comparative evaluation of total antioxidant capacities of plant polyphenols. Molecules. 21:pii.E208. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Orozco TJ, Wang JF and Keen CL: Chronic consumption of a flavanol- and procyanindin-rich diet is associated with reduced levels of 8-hydroxy-2′-deoxyguanosine in rat testes. J Nutr Biochem. 14:104–110. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Burri SH, Kim CN, Fang G, Chang BS, Perkins C, Harris W, Davis LW, Thompson CB and Bhalla KN: ‘Loop’ domain deletional mutant of Bcl-xL is as effective as p29Bcl-xL in inhibiting radiation-induced cytosolic accumulation of cytochrome c (cyt c), caspase-3 activity and apoptosis. Int J Radiat Oncol Biol Phys. 43:423–430. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Bi F, Li Y, Yin H, Deng N, Pan H, Li D and Xiao B: α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med 13: 1143-1150, 2017.
APA
Zhu, Y., Bi, F., Li, Y., Yin, H., Deng, N., Pan, H. ... Xiao, B. (2017). α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Experimental and Therapeutic Medicine, 13, 1143-1150. https://doi.org/10.3892/etm.2017.4045
MLA
Zhu, Y., Bi, F., Li, Y., Yin, H., Deng, N., Pan, H., Li, D., Xiao, B."α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage". Experimental and Therapeutic Medicine 13.3 (2017): 1143-1150.
Chicago
Zhu, Y., Bi, F., Li, Y., Yin, H., Deng, N., Pan, H., Li, D., Xiao, B."α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage". Experimental and Therapeutic Medicine 13, no. 3 (2017): 1143-1150. https://doi.org/10.3892/etm.2017.4045
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Bi F, Li Y, Yin H, Deng N, Pan H, Li D and Xiao B: α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med 13: 1143-1150, 2017.
APA
Zhu, Y., Bi, F., Li, Y., Yin, H., Deng, N., Pan, H. ... Xiao, B. (2017). α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Experimental and Therapeutic Medicine, 13, 1143-1150. https://doi.org/10.3892/etm.2017.4045
MLA
Zhu, Y., Bi, F., Li, Y., Yin, H., Deng, N., Pan, H., Li, D., Xiao, B."α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage". Experimental and Therapeutic Medicine 13.3 (2017): 1143-1150.
Chicago
Zhu, Y., Bi, F., Li, Y., Yin, H., Deng, N., Pan, H., Li, D., Xiao, B."α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage". Experimental and Therapeutic Medicine 13, no. 3 (2017): 1143-1150. https://doi.org/10.3892/etm.2017.4045
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