Open Access

Vascular response profiles following a nano polymer‑free sirolimus‑eluting stent implantation assessed by optical coherence tomography in a porcine model

  • Authors:
    • Li Ma
    • Qiang Fu
    • Hongyu Hu
    • Wei Chen
    • Li Li
    • Zhixu Tan
    • Buxing Chen
  • View Affiliations

  • Published online on: January 19, 2017     https://doi.org/10.3892/etm.2017.4061
  • Pages: 829-834
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Optical coherence tomography (OCT) is a high resolution imaging modality and has been considered as the ideal tool for the evaluation of neointimal tissue and vascular responses following stent implantation. However, vascular response profiles following the implantation of a novel nano polymer‑free sirolimus‑eluting stent (SES) assessed by OCT has not been fully investigated. Therefore, the aim of the present study was to determine the effects of a nano polymer‑free SES on neointimal formation using OCT. A total of 16 nano polymer‑free SESs were implanted in the coronary arteries of 8 pigs. At 3 (n=4) or 6 months (n=4), the animals were euthanized following OCT evaluation and the stented arterial segments were analyzed by histological analysis. Neointimal area, thickness and burden were evaluated by OCT. In addition, strut‑associated inflammation, stent endothelialization and arterial injury were investigated by histomorphological analysis. OCT examination showed that at 6 months, neointimal thickness (193.3±109.5 vs. 167.2±119.7 µm, P=0.023) and neointimal burden (29.3±14.3 vs. 24.8±17.4%, P=0.006) significantly increased compared with at 3 months. Histomorphological analysis indicated that the endothelialization score was significantly greater at 6 months compared with at 3 months (2.85±0.36 vs. 2.52±0.60, P<0.001). However, at 3 months, nano polymer‑free SES showed a significantly higher inflammatory score [0 (0, 1) vs. 0 (0, 0), P<0.001] compared with at 6 months. In conclusion, nano polymer‑free SES achieves endothelialization at 3 months; however, neointimal proliferation is more significant at 6 months and may be attributed to strut‑associated inflammation.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ma L, Fu Q, Hu H, Chen W, Li L, Tan Z and Chen B: Vascular response profiles following a nano polymer‑free sirolimus‑eluting stent implantation assessed by optical coherence tomography in a porcine model. Exp Ther Med 13: 829-834, 2017
APA
Ma, L., Fu, Q., Hu, H., Chen, W., Li, L., Tan, Z., & Chen, B. (2017). Vascular response profiles following a nano polymer‑free sirolimus‑eluting stent implantation assessed by optical coherence tomography in a porcine model. Experimental and Therapeutic Medicine, 13, 829-834. https://doi.org/10.3892/etm.2017.4061
MLA
Ma, L., Fu, Q., Hu, H., Chen, W., Li, L., Tan, Z., Chen, B."Vascular response profiles following a nano polymer‑free sirolimus‑eluting stent implantation assessed by optical coherence tomography in a porcine model". Experimental and Therapeutic Medicine 13.3 (2017): 829-834.
Chicago
Ma, L., Fu, Q., Hu, H., Chen, W., Li, L., Tan, Z., Chen, B."Vascular response profiles following a nano polymer‑free sirolimus‑eluting stent implantation assessed by optical coherence tomography in a porcine model". Experimental and Therapeutic Medicine 13, no. 3 (2017): 829-834. https://doi.org/10.3892/etm.2017.4061