Changes in liver stiffness and its associated factors during oral antiviral therapy in Chinese patients with chronic hepatitis B

Li,Xu; Jin,Qinglong; Zhang,Hong; Jing,Xue; Ding,Zhongyang; Zhou,Hongjie; Zhang,Zetian; Yan,Dongqing; Li,Dongmei; Gao,Pujun; Niu,Junqi

doi:10.3892/etm.2017.4065

March-2017 Volume 13 Issue 3

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March-2017 Volume 13 Issue 3

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Article

Changes in liver stiffness and its associated factors during oral antiviral therapy in Chinese patients with chronic hepatitis B

Authors:
- Xu Li
- Qinglong Jin
- Hong Zhang
- Xue Jing
- Zhongyang Ding
- Hongjie Zhou
- Zetian Zhang
- Dongqing Yan
- Dongmei Li
- Pujun Gao
- Junqi Niu
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Affiliations: Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Phase I Clinical Trials Unit, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Gastroenterology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong 266000, P.R. China
Pages: 1169-1175
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Published online on: January 19, 2017

https://doi.org/10.3892/etm.2017.4065
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Abstract

The present study aimed to assess improvements in liver stiffness determined by transient elastography and associated factors in Chinese patients with chronic hepatitis B (CHB) during long‑term treatment with oral antiviral drugs. A total of 334 consecutive Chinese patients with CHB who underwent oral antiviral therapy and received at least two liver stiffness measurements (LSMs) at the First Hospital of Jilin University (Changchun, China) from December 2012 to February 2015 were enrolled in the present study. The cohort included 201 patients without liver cirrhosis (group 0) and 133 patients with liver cirrhosis (group 1). Each patient was subjected to LSM twice with an interval of 6 months. The mean initial liver stiffness values were 14.01±9.37 and 21.59±10.25 kPa for patients in group 0 and group 1, respectively (P<0.001). Multivariate analysis revealed that higher aspartate aminotransferase and lower alanine aminotransferase levels at baseline as well as higher α‑fetoprotein levels at follow‑up (24 weeks) were associated with a greater decline of liver stiffness in group 0. Furthermore, a higher liver stiffness at baseline and a longer course of antiviral therapy prior to the initial LSM were significantly correlated with a reduction of liver stiffness, whereas higher total bilirubin levels at follow‑up contributed to increased liver stiffness in group 1. In conclusion, LSM at the beginning and the end of a 24‑week observation period showed that antiviral drug therapy significantly improved in group 1, while a marked decreasing trend was also observed in group 0. In group 0, the reduction of liver stiffness was correlated with liver inflammation, whereas in group 1, it was correlated with the treatment duration prior to the initial LSM and serum levels of hepatitis B virus DNA. Furthermore, a higher liver stiffness at baseline was associated with a greater reduction of liver stiffness in each group.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Changes in liver stiffness and its associated factors during oral antiviral therapy in Chinese patients with chronic hepatitis B

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