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Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver

  • Authors:
    • Mihaela Zaulet
    • Steliana Elvira Maria Kevorkian
    • Sorina Dinescu
    • Coralia Cotoraci
    • Maria Suciu
    • Hildegard Herman
    • Laura Buburuzan
    • Liliana Badulescu
    • Aurel Ardelean
    • Anca Hermenean
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania, Department of Experimental and Applied Biology, Institute of Life Sciences, ‘Vasile Goldiș’ Western University of Arad, 310414 Arad, Romania, Department of Hematology, Faculty of Medicine, Pharmacy and Dentistry, ‘Vasile Goldiș’ Western University of Arad, 310414 Arad, Romania, Department of Cell Biology, Faculty of Medicine, ‘Vasile Goldiș’ Western University of Arad, 310414 Arad, Romania, Department of Bioengineering of Horti‑Viticultural System, University of Agronomical Science and Veterinary Medicine, 011464 Bucharest, Romania
    Copyright: © Zaulet et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 821-828
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    Published online on: January 20, 2017
       https://doi.org/10.3892/etm.2017.4066
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Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical released into the environment, with severe consequences for human health, including metabolic syndrome and associated pathological conditions. Due to limited information on BPA‑induced hepatotoxicity, the present study focused on investigating the association between BPA‑induced toxicity and inflammatory markers in the liver, and how these injuries may be alleviated using the natural agent silymarin, a flavonoid with antioxidant properties obtained from Silybum marianum. Administration of BPA to male CD‑1 mice for 10 days caused a significant increase in the number of cells immunopositive for interleukin 6 and tumor necrosis factor‑α, pro‑inflammatory cytokines that mediate the hepatic inflammatory response. Treatment with 200 mg/kg of silymarin concurrently with BPA for 10 days resulted in a diminished level of pro‑inflammatory cytokines and in significantly reduced ultrastructural injuries. Additionally, silymarin was able to restore the significantly decreased glycogen deposits observed following BPA exposure to normal levels, thus favoring hepatic glycogenesis. This study represents the first report of silymarin ability to reduce hepatic lesions and to counteract inflammation caused by BPA in mice. A dose of 200 mg/kg silymarin was sufficient to induce a protective effect against structural and ultrastructural injuries induced by BPA and to lower the levels of pro‑inflammatory cytokines observed in murine liver tissue following exposure to BPA.
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View References

1 

Abdel-Wahab WM: Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats. Pak J Biol Sci. 17:1152–1160. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Pritchett JJ, Kuester RK and Spies IG: Metabolism of bisphenol A in primary cultured hepatocytes from mice, rats, and humans. Drug Metab Dispos. 30:1180–1185. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Takeuchi T, Tsutsumi O, Ikezuki Y, Takai Y and Taketani Y: Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction. Endocr J. 51:165–169. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Mendiola J, Jørgensen N, Andersson AM, Calafat AM, Ye X, Redmon JB, Drobnis EZ, Wang C, Sparks A, Thurston SW, et al: Are environmental levels of bisphenol a associated with reproductive function in fertile men? Environ Health Perspect. 118:1286–1291. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Pupo M, Pisano A, Lappano R, Santolla MF, De Francesco EM, Abonante S, Rosano C and Maggiolini M: Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts. Environ Health Perspect. 120:1177–1182. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB and Melzer D: Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA. 300:1303–1310. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Duan B, Hu X, Zhao H, Qin J and Luo J: The relationship between urinary bisphenol A levels and meningioma in Chinese adults. Int J Clin Oncol. 18:492–497. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Rubin BS: Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol. 127:27–34. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Vom Saal FS, Nagel SC, Coe BL, Angle BM and Taylor JA: The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol Cell Endocrinol. 354:74–84. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Rodríguez-Hernández H, Simental-Mendía LE, Rodríguez-Ramírez G and Reyes-Romero MA: Obesity and inflammation: Epidemiology, risk factors, and markers of inflammation. Int J Endocrinol. 2013:6781592013. View Article : Google Scholar : PubMed/NCBI

11 

Savastano S, Tarantino G, D'Esposito V, Passaretti F, Cabaro S, Liotti A, Liguoro D, Perruolo G, Ariemma F, Finelli C, et al: Bisphenol-A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: A cross-sectional study on adult male population. J Transl Med. 13:1692015. View Article : Google Scholar : PubMed/NCBI

12 

Weinhouse C, Anderson OS, Bergin IL, Vandenbergh DJ, Gyekis JP, Dingman MA, Yang J and Dolinoy DC: Dose-dependent incidence of hepatic tumors in adult mice following perinatal exposure to bisphenol A. Environ Health Perspect. 122:485–491. 2014.PubMed/NCBI

13 

Wetherill YB, Akingbemi BT, Kanno J, McLachlan JA, Nadal A, Sonnenschein C, Watson CS, Zoeller RT and Belcher SM: In vitro molecular mechanisms of bisphenol A action. Reprod Toxicol. 24:178–198. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Asahi J, Kamo H, Baba R, Doi Y, Yamashita A, Murakami D, Hanada A and Hirano T: Bisphenol A induces endoplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes. Life Sci. 87:431–438. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Bindhumol V, Chitra KC and Mathur PP: Bisphenol A induces reactive oxygen species generation in the liver of male rats. Toxicology. 188:117–124. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ and Park KS: Bisphenol a impairs mitochondrial function in the liver at doses below the no observed adverse effect level. J Korean Med Sci. 27:644–652. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Kang JS, Jeon YJ, Park SK, Yang KH and Kim HM: Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1beta and prostaglandin E2 synthesis by silymarin. Biochem Pharmacol. 67:175–181. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Najafzadeh H, Jalali MR, Morovvati H and Taravati F: Comparison of the prophylactic effect of silymarin and deferoxamine on iron overload induced hepatotoxicity in rat. J Med Toxicol. 6:22–26. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Chtourou Y, Garoui E, Boudawara T and Zeghal N: Therapeutic efficacy of silymarin from milk thistle in reducing manganese-induced hepatic damage and apoptosis in rats. Hum Exp Toxicol. 32:70–81. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Panda V, Ashar H and Srinath S: Antioxidant and hepatoprotective effect of Garcinia indica fruit rind in ethanol-induced hepatic damage in rodents. Interdiscip Toxicol. 5:207–213. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Jia R, Cao L, Du J, Xu P, Jeney G and Yin G: The protective effect of silymarin on the carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio). In Vitro Cell Dev Biol Anim. 49:155–161. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Hermenean A, Stan M, Ardelean A, et al: Antiioxidant and hepatoprotective activity of milk thistle (Silybum marianum L. Gaertn.) seed oil. Open Life Sci. 10:225–236. 2015.

23 

Das S, Roy P, Auddy RG and Mukherjee A: Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity. Int J Nanomedicine. 6:1291–1301. 2011.PubMed/NCBI

24 

Mansour HH, Hafez HF and Fahmy NM: Silymarin modulates Cisplatin induced oxidative stress and hepatotoxicity in rats. J Biochem Mol Biol. 39:656–661. 2006.PubMed/NCBI

25 

Sasu A, Herman H, Mariasiu T, Rosu M, Balta C, Anghel N, Miutescu E, Cotoraci C and Hermenean A: Protective effects of silymarin on epirubicin-induced mucosal barrier injury of the gastrointestinal tract. Drug Chem Toxicol. 38:442–451. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Rašković A, Stilinović N, Kolarović J, Vasović V, Vukmirović S and Mikov M: The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats. Molecules. 16:8601–8613. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Vargas-Mendoza N, Madrigal-Santillán E, Morales-González A, Esquivel-Soto J, Esquivel-Chirino C, García-Luna Y, González-Rubio M, Gayosso-de-Lucio JA and Morales-González JA: Hepatoprotective effect of silymarin. World J Hepatol. 6:144–149. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Karimi G, Vahabzadeh M, Lari P, Rashedinia M and Moshiri M: ‘Silymarin’, a promising pharmacological agent for treatment of diseases. Iran J Basic Med Sci. 14:308–317. 2011.PubMed/NCBI

29 

Tsai JH, Liu JY, Wu TT, Ho PC, Huang CY, Shyu JC, Hsieh YS, Tsai CC and Liu YC: Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Viral Hepat. 15:508–514. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Ahmad I, Shukla S, Kumar A, Singh BK, Kumar V, Chauhan AK, Singh D, Pandey HP and Singh C: Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. Chem Biol Interact. 201:9–18. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Wu HJ, Liu C, Duan WX, Xu SC, He MD, Chen CH, Wang Y, Zhou Z, Yu ZP, Zhang L and Chen Y: Melatonin ameliorates bisphenol A-induced DNA damage in the germ cells of adult male rats. Mutat Re. 752:57–67. 2013. View Article : Google Scholar

32 

Roelofs MJ, van den Berg M, Bovee TF, Piersma AH and van Duursen MB: Structural bisphenol analogues differentially target steroidogenesis in murine MA-10 Leydig cells as well as the glucocorticoid receptor. Toxicology. 329:10–20. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Rezg R, El-Fazaa S, Gharbi N and Mornagui B: Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives. Environ Int. 64:83–90. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Markiewski MM, DeAngelis RA and Lambris JD: Liver inflammation and regeneration: Two distinct biological phenomena or parallel pathophysiologic processes? Mol Immunol. 43:45–56. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey DE, Kaufmann W, Küttler K, Deschl U, et al: Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol Pathol. 38(7): Suppl. 5S–81S. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Atsafack SS, Kuiate JR, Mouokeu RS, Mogtomo ML Koanga, Tchinda AT, De Dieu TJ, Nana H Magnifouet, Etame RM Ebelle, Biyiti L and Ngane RA Ngono: Toxicological studies of stem bark extract from Schefflera barteri Harms (Araliaceae). BMC Complement Altern Med. 15:442015. View Article : Google Scholar : PubMed/NCBI

37 

Weiss MJ: Cytokines in liver, biliary and pancreatic diseaseBlumgart's Surgery of the Liver, Pancreas and Biliary Tract. Jarnagin W: 5th. Elsevier, Inc.; Philadelphia, PA: pp. 166–180. 2012, View Article : Google Scholar

38 

Choi I, Kang HS, Yang Y and Pyun KH: IL-6 induces hepatic inflammation and collagen synthesis in vivo. Clin Exp Immunol. 95:530–535. 1994. View Article : Google Scholar : PubMed/NCBI

39 

Norris CA, He M, Kang LI, Ding MQ, Radder JE, Haynes MM, Yang Y, Paranjpe S, Bowen WC, Orr A, et al: Synthesis of IL-6 by hepatocytes is a normal response to common hepatic Stimuli. PLoS One. 9:e960532014. View Article : Google Scholar : PubMed/NCBI

40 

Sherif IO and Al-Gayyar MMH: Antioxidant, anti-inflammatory and hepatoprotective effects of silymarin on hepatic dysfunction induced by sodium nitrite. Eur Cytokine Netw. 24:114–121. 2013.PubMed/NCBI

41 

Lovelace ES, Wagoner J, MacDonald J, Bammler T, Bruckner J, Brownell J, Beyer RP, Zink EM, Kim YM, Kyle JE, et al: Silymarin suppresses cellular inflammation by inducing reparative stress signaling. J Nat Prod. 78:1990–2000. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Pękalski J, Zuk PJ, Kochańczyk M, Junkin M, Kellogg R, Tay S and Lipniacki T: Spontaneous NF-kB activation by autocrine TNFa Signaling: A computational analysis. PLoS One. 8:e788872013. View Article : Google Scholar : PubMed/NCBI

43 

Kabuto H, Amakawa M and Shishibori T: Exposure to bisphenol A during embryonic/fetal life and infancy increases oxidative injury and causes underdevelopment of the brain and testis inmice. Life Sci. 74:2931–2940. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Korkmaz A, Ahbab MA, Kolankaya D and Barlas N: Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats. Food Chem Toxicol. 48:2865–2871. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Suthar H, Verma RJ, Patel S and Jasrai YT: Green tea potentially ameliorates bisphenol a-induced oxidative stress: An in vitro and in silico study. Biochem Res Int. 2014:2597632014. View Article : Google Scholar : PubMed/NCBI

46 

Doerge DR and Fisher JW: Background paper on metabolism and toxicokinetics of bisphenol A. Proceedings of the WHO/HSE/FOS/11.1 Expert Meeting on Bisphenol A (BPA'10). World Health Organization. Geneva. 2010;

47 

Xia W, Jiang Y, Li Y, Wan Y, Liu J, Ma Y, Mao Z, Chang H, Li G, Xu B, et al: Early-life exposure to bisphenol a induces liver injury in rats Involvement of mitochondria-mediated apoptosis. PLoS One. 9:e904432014. View Article : Google Scholar : PubMed/NCBI

48 

Muriel P, Garciapiña T, Perez-Alvarez V and Mourelle M: Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J Appl Toxicol. 12:439–442. 1992. View Article : Google Scholar : PubMed/NCBI

49 

Jayashree S, Indumathi D, Akilavalli N, Sathish S, Selvaraj J and Balasubramanian K: Effect of Bisphenol-A on insulin signal transduction and glucose oxidation in liver of adult male albino rat. Environ Toxicol Pharmacol. 35:300–310. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Abouzeinab NS: Cytoprotective effect and antioxidant properties of silymarin on cisplatin induced hepatotoxicity in rats: A biochemical and histochemical study. International Journal of Cancer Research. 9:9–23. 2013. View Article : Google Scholar

51 

Nelson DL and Cox MM: Lehninger Principles of Biochemistry. 5th. W.H. Freeman and Co.; New York, NY: pp. 540–550. 2008

52 

Ebaid H, Dkhil MA, Danfour MA, Tohamy A and Gabry MS: Piroxicam-induced hepatic and renal histopathological changes in mice. Libyan J Med. 2:82–89. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Miyamato Y, Shimada K, Sakaguchi Y and Miyamoto M: Cisplatin (CCDP)-induced acute toxicity in an experimental model of hepatic fibrosis. J Toxicol Sci. 32:311–319. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Rosner MH and Okusa M: Biomarkers in Renal Disease. 5th. Nova Publishers; New York, NY: pp. 21–45. 2008

55 

Salam OM Abdel, Sleem AA, Omara EA and Hassan NS: Effect of ribavirin alone or combined with silymarin on carbon tetrachloride induced hepatic damage in rats. Drug Target Insights. 2:19–27. 2007.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zaulet M, Kevorkian SE, Dinescu S, Cotoraci C, Suciu M, Herman H, Buburuzan L, Badulescu L, Ardelean A, Hermenean A, Hermenean A, et al: Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver. Exp Ther Med 13: 821-828, 2017.
APA
Zaulet, M., Kevorkian, S.E., Dinescu, S., Cotoraci, C., Suciu, M., Herman, H. ... Hermenean, A. (2017). Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver. Experimental and Therapeutic Medicine, 13, 821-828. https://doi.org/10.3892/etm.2017.4066
MLA
Zaulet, M., Kevorkian, S. E., Dinescu, S., Cotoraci, C., Suciu, M., Herman, H., Buburuzan, L., Badulescu, L., Ardelean, A., Hermenean, A."Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver". Experimental and Therapeutic Medicine 13.3 (2017): 821-828.
Chicago
Zaulet, M., Kevorkian, S. E., Dinescu, S., Cotoraci, C., Suciu, M., Herman, H., Buburuzan, L., Badulescu, L., Ardelean, A., Hermenean, A."Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver". Experimental and Therapeutic Medicine 13, no. 3 (2017): 821-828. https://doi.org/10.3892/etm.2017.4066
Copy and paste a formatted citation
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Spandidos Publications style
Zaulet M, Kevorkian SE, Dinescu S, Cotoraci C, Suciu M, Herman H, Buburuzan L, Badulescu L, Ardelean A, Hermenean A, Hermenean A, et al: Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver. Exp Ther Med 13: 821-828, 2017.
APA
Zaulet, M., Kevorkian, S.E., Dinescu, S., Cotoraci, C., Suciu, M., Herman, H. ... Hermenean, A. (2017). Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver. Experimental and Therapeutic Medicine, 13, 821-828. https://doi.org/10.3892/etm.2017.4066
MLA
Zaulet, M., Kevorkian, S. E., Dinescu, S., Cotoraci, C., Suciu, M., Herman, H., Buburuzan, L., Badulescu, L., Ardelean, A., Hermenean, A."Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver". Experimental and Therapeutic Medicine 13.3 (2017): 821-828.
Chicago
Zaulet, M., Kevorkian, S. E., Dinescu, S., Cotoraci, C., Suciu, M., Herman, H., Buburuzan, L., Badulescu, L., Ardelean, A., Hermenean, A."Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver". Experimental and Therapeutic Medicine 13, no. 3 (2017): 821-828. https://doi.org/10.3892/etm.2017.4066
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