Epidemiological analysis of 9,596 patients with acute lung injury at Chinese Military Hospitals

Zhou,Daijun; Qiu,Jun; Liang,Yi; Dai,Wei; Yuan,Danfeng; Zhou,Jihong

doi:10.3892/etm.2017.4068

Epidemiological analysis of 9,596 patients with acute lung injury at Chinese Military Hospitals

Authors:
- Daijun Zhou
- Jun Qiu
- Yi Liang
- Wei Dai
- Danfeng Yuan
- Jihong Zhou
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Affiliations: State Key Laboratory of Trauma, Burns and Combined Injury, Department 4, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China
Published online on: January 20, 2017 https://doi.org/10.3892/etm.2017.4068
Pages: 983-988

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Abstract

Acute lung injury (ALI) is a common and severe disease that has been associated with significant morbidity and mortality. Understanding the epidemiology of ALI is vital for its prevention and treatment. The present study aimed to analyze the epidemiology of ALI by collecting data from patients that were submitted between 2000 and 2008 into the ‘No. 1 Military Medical Project’ information system. A total of 9,596 ALI patients were analyzed retrospectively, including 7,284 males (75.91%) and 2,312 females (24.09%). The median age of the patients was 44 years (interquartile range, 31‑63 years), and there was a significant difference between the median ages of male and female patients (P<0.01). The number of patients with ALI admitted to the hospitals showed an increasing trend over time. However, there was no significant difference in the annual gender distribution (P>0.05). In addition, ALI was more prevalent in May, July, August, October, November and December, as compared with the other months. ALI occurred at any age, although 40‑years‑old was the peak age. There was a significant difference in the age group distributions of male and female ALI patients (P<0.01). Among the predisposing conditions, pulmonary contusion represented the highest proportion (45.71%), followed by pneumonia or respiratory tract infection (23.68%) and pulmonary malignant tumor (6.30%). Of the 581 (6.05%) mortalities, pneumonia was the most common cause (37.87%), followed by malignancies (16.87%) and pulmonary embolism (11.02%). However, the highest mortality rate was associated with cardiopulmonary resuscitation (48.28%). In conclusion, the results of the present study suggested that ALI should be increasingly monitored in the future, and predisposing conditions should be regarded as one of the most important features determining the management of ALI.

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1	Definition Task Force ARDS. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L and Slutsky AS: Acute respiratory distress syndrome: The Berlin Definition. JAMA. 307:2526–2533. 2012.PubMed/NCBI
2	Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A and Spragg R: The American-European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 149:818–824. 1994. View Article : Google Scholar : PubMed/NCBI
3	Vasilyev S, Schaap RN and Mortensen JD: Hospital survival rates of patients with acute respiratory failure in modern respiratory intensive care units. An international, multicenter, prospective survey. Chest. 107:1083–1088. 1995. View Article : Google Scholar : PubMed/NCBI
4	Lewandowski K, Metz J, Deutschmann C, Preiss H, Kuhlen R, Artigas A and Falke KJ: Incidence, severity and mortality of acute respiratory failure in Berlin, Germany. Am J Respir Crit Care Med. 151:1121–1125. 1995. View Article : Google Scholar : PubMed/NCBI
5	Phua J, Badia JR, Adhikari NK, Friedrich JO, Fowler RA, Singh JM, Scales DC, Stather DR, Li A, Jones A, et al: Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review. Am J Respir Crit Care Med. 179:220–227. 2009. View Article : Google Scholar : PubMed/NCBI
6	Luhr OR, Antonsen K, Karlsson M, Aardal S, Thorsteinsson A, Frostell CG and Bonde J: Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark and Iceland. The ARF Study Group. Am J Respir Crit Care Med. 159:1849–1861. 1999. View Article : Google Scholar : PubMed/NCBI
7	Frutos-Vivar F, Nin N and Esteban A: Epidemiology of acute lung injury and acute respiratory distress syndrome. Curr Opin Crit Care. 10:1–6. 2004. View Article : Google Scholar : PubMed/NCBI
8	Webster NR, Cohen AT and Nunn JF: Adult respiratory distress syndrome-how many cases in the UK? Anaesthesia. 43:923–926. 1988. View Article : Google Scholar : PubMed/NCBI
9	Fowler AA, Hamman RF, Good JT, Benson KN, Baird M, Eberle DJ, Petty TL and Hyers TM: Adult respiratory distress syndrome: Risk with common predispositions. Ann Intern Med. 98:593–597. 1983. View Article : Google Scholar : PubMed/NCBI
10	Irish Critical Care Trials Group, . Acute lung injury and the acute respiratory distress syndrome in Ireland: A prospective audit of epidemiology and management. Crit Care. 12:R302008. View Article : Google Scholar : PubMed/NCBI
11	Roupie E, Lepage E, Wysocki M, Fagon JY, Chastre J, Dreyfuss D, Mentec H, Carlet J, Brun-Buisson C, Lemaire F and Brochard L: Prevalence, etiologies and outcome of the acute respiratory distress syndrome among hypoxemic ventilated patients. SRLF collaborative group on mechanical ventilation. Société de Réanimation de Langue Française. Intensive Care Med. 25:920–929. 1999. View Article : Google Scholar : PubMed/NCBI
12	Suchyta MR, Clemmer TP, Elliott CG, Orme JF Jr and Weaver LK: The adult respiratory distress syndrome. A report of survival and modifying factors. Chest. 101:1074–1079. 1992. View Article : Google Scholar : PubMed/NCBI
13	Monchi M, Bellenfant F, Cariou A, Joly LM, Thebert D, Laurent I, Dhainaut JF and Brunet F: Early predictive factors of survival in the acute respiratory distress syndrome. A multivariate analysis. Am J Respir Crit Care Med. 158:1076–1081. 1998. View Article : Google Scholar : PubMed/NCBI
14	Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP and Matthay MA: Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med. 152:1818–1824. 1995. View Article : Google Scholar : PubMed/NCBI
15	Eisner MD, Thompson T, Hudson LD, Luce JM, Hayden D, Schoenfeld D and Matthay MA: Acute Respiratory Distress Syndrome Network: Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med. 164:231–236. 2001. View Article : Google Scholar : PubMed/NCBI
16	Page B, Vieillard-Baron A, Beauchet A, Aegerter P, Prin S and Jardin F: Low stretch ventilation strategy in acute respiratory distress syndrome: Eight years of clinical experience in a single center. Crit Care Med. 31:765–769. 2003. View Article : Google Scholar : PubMed/NCBI
17	Esteban A, Anzueto A, Frutos F, Alía I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguía C, Nightingale P, et al: Characteristics and outcomes in adult patients receiving mechanical ventilation: A 28-day international study. JAMA. 287:345–355. 2002. View Article : Google Scholar : PubMed/NCBI