Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease

  • Authors:
    • Caner Arslan
    • Burcu Bayoglu
    • Cigdem Tel
    • Mujgan Cengiz
    • Ahmet Dirican
    • Kazim Besirli
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey, Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey, Department of Biostatistics and Medical Informatics, Istanbul Medical Faculty, Istanbul University, Istanbul 34093, Turkey
  • Pages: 1160-1168
    |
    Published online on: January 24, 2017
       https://doi.org/10.3892/etm.2017.4081
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oxidized low-density lipoprotein receptor 1 (OLR1) and interleukin 17A (IL17A) have pro-inflammatory roles in the development of cardiovascular disorders. The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease. The mRNA expression of OLR1 and IL17A in peripheral blood mononuclear cells as well as the frequency of OLR1 rs11053646 and IL17A rs8193037 and rs3819025 polymorphisms were assessed by polymerase chain reaction in 70 patients with FP artery disease and 80 age‑matched disease‑free controls. Furthermore, the levels of plasma cytokines were assessed by multiplex immunoassay. OLR1 and IL17A mRNA expression was significantly higher in patients with FP artery disease compared with that in controls (P<0.001). No significant difference was observed in the genotypic frequencies of OLR1 rs11053646 (P=0.87) or in IL17A rs8193037 and rs3819025 (P=0.80 and 0.92, respectively) polymorphisms between patients with FP artery disease and controls. Plasma IL4, ‑6, ‑10, ‑22, ‑31 and ‑33 as well as soluble cluster of differentiation 40 ligand and tumor necrosis factor‑α levels were significantly increased among FP artery disease patients compared with controls (P<0.05). Furthermore, OLR1 expression was positively correlated with triglyceride (r=0.463, P<0.001), low‑density lipoprotein cholesterol (r=0.507, P<0.001) and total cholesterol levels (r=0.357, P=0.006) in patients with FP artery disease. To the best of our knowledge, the present study was the first to identify an association between OLR1 and IL17A genes and FP artery disease. OLR1 and IL17A mRNA transcripts may be associated with blood lipid parameters and with the development of FP artery disease.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG; TASC II Working Group; Bell K, Caporusso J, Durand-Zaleski I, et al: Inter-Society consensus for the management of peripheral arterial disease (TASC II). Eur J Vasc Endovasc Surg. 33:(Suppl 1). S1–S75. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Hernando FJ Serrano and Martín Conejero A: Peripheral artery disease: Pathophysiology, diagnosis and treatment. Rev Esp Cardiol. 60:969–982. 2007.(In Spanish). PubMed/NCBI

3 

Mahameed AA: Peripheral arterial disease. http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/peripheral-arterial-disease/Accessed. January 11–2009.

4 

Kullo IJ and Leeper NJ: The genetic basis of peripheral arterial disease: Current knowledge, challenges, and future directions. Circ Res. 116:1551–1560. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Chen XP and Du GH: Lectin-like oxidized low-density lipoprotein receptor-1: Protein, ligands, expression and pathophysiological significance. Chin Med J (Engl). 120:421–426. 2007.PubMed/NCBI

6 

Arjuman A and Chandra NC: Effect of IL-10 on LOX-1 expression, signaling and functional activity: An atheroprotective response. Diab Vasc Dis Res. 10:442–451. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Tesmer LA, Lundy SK, Sarkar S and Fox DA: Th17 cells in human disease. Immunol Rev. 223:87–113. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Taleb S, Tedgui A and Mallat Z: Adaptive T cell immune responses and atherogenesis. Curr Opin Pharmacol. 10:197–202. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Madhur MS, Lob HE, McCann LA, Iwakura Y, Blinder Y, Guzik TJ and Harrison DG: Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension. 55:500–507. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Zhang X, Pei F, Zhang M, Yan C, Huang M, Wang T and Han Y: Interleukin-17A gene variants and risk of coronary artery disease: A large angiography-based study. Clin Chim Acta. 412:327–331. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Mai J, Nanayakkara G, Lopez-Pastrana J, Li X, Li YF, Wang X, Song A, Virtue A, Shao Y, Shan H, et al: Interleukin-17A promotes aortic endothelial cell activation via transcriptionally and post-translationally activating p38 mitogen-activated protein kinase (MAPK) pathway. J Biol Chem. 291:4939–4954. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Biocca S, Falconi M, Filesi I, Baldini F, Vecchione L, Mango R, Romeo F, Federici G, Desideri A and Novelli G: Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity. PLoS One. 4:e46482009. View Article : Google Scholar : PubMed/NCBI

13 

Tatsuguchi M, Furutani M, Hinagata J, Tanaka T, Furutani Y, Imamura S, Kawana M, Masaki T, Kasanuki H, Sawamura T and Matsuoka R: Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. Biochem Biophys Res Commun. 303:247–250. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Hou XW, Wang LF, Wang N, Pang D, Hui B, Zhou YL and He X: The G501C polymorphism of oxidized LDL receptor gene [OLR-1] is associated with susceptibility and serum C-reactive protein concentration in Chinese essential hypertensives. Clin Chim Acta. 388:200–203. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Hattori H, Sonoda A, Sato H, Ito D, Tanahashi N, Murata M, Saito I, Watanabe K and Suzuki N: G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke. Brain Res. 1121:246–249. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Zhang J, Yin C, Zhang Y, Zhao L, Fu H and Feng J: The role of OLR1 polymorphisms in determining the risk and prognosis of ischemic stroke in a Chinese population. NeuroRehabilitation. 32:391–396. 2013.PubMed/NCBI

17 

Liu X, Zhu RX, Li L and He ZY: Association of LOX-1 gene polymorphisms with cerebral infarction in northern Chinese Han population. Lipids Health Dis. 13:552014. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Libby P, Ridker PM and Maseri A: Inflammation and atherosclerosis. Circulation. 105:1135–1143. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Dunn S, Vohra RS, Murphy JE, Homer-Vanniasinkam S, Walker JH and Ponnambalam S: The lectin-like oxidized low-density-lipoprotein receptor: A pro-inflammatory factor in vascular disease. Biochem J. 409:349–355. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Liuzzo G, Trotta F and Pedicino D: Interleukin-17 in atherosclerosis and cardiovascular disease: The good, the bad, and the unknown. Eur Heart J. 34:556–559. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Lim H, Kim YU, Sun H, Lee JH, Reynolds JM, Hanabuchi S, Wu H, Teng BB and Chung Y: Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo. Immunity. 40:153–165. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Goyal T, Mitra S, Khaidakov M, Wang X, Singla S, Ding Z, Liu S and Mehta JL: Current concepts of the role of oxidized LDL receptors in atherosclerosis. Curr Atheroscler Rep. 2012.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

24 

Hansson GK and Hermansson A: The immune system in atherosclerosis. Nat Immunol. 12:204–212. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Gao S and Geng YJ: LOX-1: A male hormone-regulated scavenger receptor for atherosclerosis. Vascul Pharmacol. 59:138–143. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Fukui M, Tanaka M, Senmaru T, Nakanishi M, Mukai J, Ohki M, Asano M, Yamazaki M, Hasegawa G and Nakamura N: LOX-1 is a novel marker for peripheral artery disease in patients with type 2 diabetes. Metabolism. 62:935–938. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Ding Z, Mizeracki AM, Hu C and Mehta JL: LOX-1 deletion and macrophage trafficking in atherosclerosis. Biochem Biophys Res Commun. 440:210–214. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Au A, Griffiths LR, Cheng KK, Wee Kooi C, Irene L and Wei L Keat: The influence of OLR1 and PCSK9 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis. Sci Rep. 5:182242015. View Article : Google Scholar : PubMed/NCBI

29 

Potekhina AV, Pylaeva E, Provatorov S, Ruleva N, Masenko V, Noeva E, Krasnikova T and Arefieva T: Treg/Th17 balance in stable CAD patients with different stages of coronary atherosclerosis. Atherosclerosis. 238:17–21. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Madhur MS, Funt SA, Li L, Vinh A, Chen W, Lob HE, Iwakura Y, Blinder Y, Rahman A, Quyyumi AA and Harrison DG: Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice. Arterioscler Thromb Vasc Biol. 31:1565–1572. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Ge S, Hertel B, Koltsova EK, Sörensen-Zender I, Kielstein JT, Ley K, Haller H and von Vietinghoff S: Increased atherosclerotic lesion formation and vascular leukocyte accumulation in renal impairment are mediated by interleukin-17A. Circ Res. 113:965–974. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Rao LN, Ponnusamy T, Philip S, Mukhopadhyay R, Kakkar VV and Mundkur L: Hypercholesterolemia induced immune response and inflammation on progression of atherosclerosis in Apob(tm2Sgy) Ldlr(tm1Her)/J mice. Lipids. 50:785–797. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Vargas-Alarcón G, Angeles-Martínez J, Villarreal-Molina T, Alvarez-León E, Posadas-Sánchez R, Cardoso-Saldaña G, Ramírez-Bello J, Pérez-Hernández N, Juárez-Rojas JG, Rodríguez-Pérez JM, et al: Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. PLoS One. 10:e01149432015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Arslan C, Bayoglu B, Tel C, Cengiz M, Dirican A and Besirli K: Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease. Exp Ther Med 13: 1160-1168, 2017.
APA
Arslan, C., Bayoglu, B., Tel, C., Cengiz, M., Dirican, A., & Besirli, K. (2017). Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease. Experimental and Therapeutic Medicine, 13, 1160-1168. https://doi.org/10.3892/etm.2017.4081
MLA
Arslan, C., Bayoglu, B., Tel, C., Cengiz, M., Dirican, A., Besirli, K."Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease". Experimental and Therapeutic Medicine 13.3 (2017): 1160-1168.
Chicago
Arslan, C., Bayoglu, B., Tel, C., Cengiz, M., Dirican, A., Besirli, K."Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease". Experimental and Therapeutic Medicine 13, no. 3 (2017): 1160-1168. https://doi.org/10.3892/etm.2017.4081
Copy and paste a formatted citation
x
Spandidos Publications style
Arslan C, Bayoglu B, Tel C, Cengiz M, Dirican A and Besirli K: Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease. Exp Ther Med 13: 1160-1168, 2017.
APA
Arslan, C., Bayoglu, B., Tel, C., Cengiz, M., Dirican, A., & Besirli, K. (2017). Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease. Experimental and Therapeutic Medicine, 13, 1160-1168. https://doi.org/10.3892/etm.2017.4081
MLA
Arslan, C., Bayoglu, B., Tel, C., Cengiz, M., Dirican, A., Besirli, K."Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease". Experimental and Therapeutic Medicine 13.3 (2017): 1160-1168.
Chicago
Arslan, C., Bayoglu, B., Tel, C., Cengiz, M., Dirican, A., Besirli, K."Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease". Experimental and Therapeutic Medicine 13, no. 3 (2017): 1160-1168. https://doi.org/10.3892/etm.2017.4081
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team