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Article Open Access

Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus

  • Authors:
    • Li Jin
    • Gao Min
    • Chen Wei
    • He Min
    • Zhou Jie
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation Medicine, Center Hospital of Xuzhou, Xuzhou, Jiangsu 221009, P.R. China, Department of Cardiopulmonary Rehabilitation, Rehabilitation Hospital of Xuzhou, Xuzhou, Jiangsu 221003, P.R. China, Academy of Medical Technology, Medical College of Xuzhou, Xuzhou, Jiangsu 221004, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 899-904
    |
    Published online on: January 24, 2017
       https://doi.org/10.3892/etm.2017.4084
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Abstract

The study was designed to observe the effects and relationship of exercise on chronotropic response (CR) and exercise capacity in patients with type 2 diabetes mellitus (T2DM). A total of 30 patients with T2DM underwent symptom‑limited cardiopulmonary exercise testing (CPET) after excluding contraindication. For each subject individualized exercise prescription was formulated, and they received 12 weeks of exercise training after CPET retest to complete the comparison of CR indicators, including the ratio of maximum exercise heart rate to predicted maximum heart rate value (rHR), heart rate reserve rate (HRRes), heart rate recovery (HRR) of 1-6 min after exercise termination (HRR1‑6), exercise capacity (peak VO2/kg) and other indicators. The results showed that after 12 weeks of exercise treatment, rHR, HRRes, HRR1-6, and peak VO2/kg were significantly higher than before (P<0.05), with peak VO2/kg being positively correlated to rHR and HRRes (P<0.01). In conclusion, exercise training can improve cardiac dysfunction, abnormal HRR, enhance exercise capacity and adaptability of the cardiovascular system to exercise stress in T2DM patients.
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1 

Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H, Ji Q, et al: China National Diabetes and Metabolic Disorders Study Group: Prevalence of diabetes among men and women in China. N Engl J Med. 362:1090–1101. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Chinese Diabetes Society (CDS), . Chinese guidelines of exercise therapy in diabetes mellitus. Chinese Diabetes Society; Beijing: pp. 46–57. 2013

3 

Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C and White RD: Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 29:1433–1438. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Brubaker PH and Kitzman DW: Chronotropic incompetence: causes, consequences, and management. Circulation. 123:1010–1020. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Dresing TJ, Blackstone EH, Pashkow FJ, Snader CE, Marwick TH and Lauer MS: Usefulness of impaired chronotropic response to exercise as a predictor of mortality, independent of the severity of coronary artery disease. Am J Cardiol. 86:602–609. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Wang ST: Effect of aerobic exercise on the balance of cardiovascular autonomic nerve. Beijing Sport University; pp. 6–9. 2006

7 

Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, et al: DIAD Investigators: Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA. 301:1547–1555. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Kaplan JM, Okin PM and Kligfield P: The diagnostic value of heart rate during exercise electrocardiography. J Cardiopulm Rehabil. 25:127–134. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Lin XF, Liu Z and Dong FY: Application and research progress of heart rate recovery in the rehabilitation of cardiovascular diseases. Chinese J Physical Med Rehabil. 35:498–500. 2013.(In Chinese).

10 

Halon DA, Dobrecky-Mery I, Gaspar T, Azencot M, Yaniv N, Peled N and Lewis BS: Heart rate recovery after exercise and coronary atheroma in asymptomatic individuals with type 2 diabetes mellitus: a study using 64-slice coronary CT angiogpaphy. Int J Cardiol. 145:102–103. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Chacko KM, Bauer TA, Dale RA, Dixon JA, Schrier RW and Estacio RO: Heart rate recovery predicts mortality and cardiovascular events in patients with type 2 diabetes. Med Sci Sports Exerc. 40:288–295. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Zhu L, Liu YN and Yu RJ: Clinical pulmonary function. 1st. People's Health Publishing House; Beijing: pp. 296–297. 2004

13 

Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, Chasan-Taber L, Albright AL and Braun B: American College of Sports Medicine; American Diabetes Association: Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care. 33:e147–e167. 2010. View Article : Google Scholar : PubMed/NCBI

14 

American Diabetes Association, . Standards of medical care in diabetes - 2010. Diabetes Care. 33:(Suppl 1). S11–S61. 2010. View Article : Google Scholar : PubMed/NCBI

15 

American College of Sports Medicine (ACSM), . ACSM's Guidelines for Exercise Testing and Prescription. 6th. Lippincott Williams & Wilkins; Philadelphia, PA: 2000

16 

Orso F, Baldasseroni S and Maggioni AP: Heart rate in coronary syndromes and heart failure. Prog Cardiovasc Dis. 52:38–45. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Lauer MS: Autonomic function and prognosis. Cleve Clin J Med. 76:(Suppl 2). S18–S22. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Goldberger JJ, Le FK, Lahiri M, Kannankeril PJ, Ng J and Kadish AH: Assessment of parasympathetic reactivation after exercise. Am J Physiol Heart Circ Physiol. 290:H2446–H2452. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Gao M, Chen W, Gong ZK, Han L and Zhang L: Correlation between chronotropic incompetence and metabolic equivalents in patients with type 2 diabetes mellitus and concomitant metabolic syndrome. Panminerva Med. 57:115–119. 2015.PubMed/NCBI

20 

Ho JS, Fitzgerald SJ, Barlow CE, Cannaday JJ, Kohl HW III, Haskell WL and Cooper KH: Risk of mortality increases with increasing number of abnormal non-ST parameters recorded during exercise testing. Eur J Cardiovasc Prev Rehabil. 17:462–468. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Zhou J, Gao M and Chen W: Relationship between heart rate recovery after exercises and mobility in type 2 diabetes patients. Acta Acad Med Xuzhou. 35:238–241. 2015.

22 

Ho PM, Maddox TM, Ross C, Rumsfeld JS and Magid DJ: Impaired chronotropic response to exercise stress testing in patients with diabetes predicts future cardiovascular events. Diabetes Care. 31:1531–1533. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Jae SY, Kurl S, Laukkanen JA, Heffernan KS, Choi YH and Park WH: Chronotropic response to exercise and risk of type 2 diabetes in men. Eur Heart J. 34:58152013. View Article : Google Scholar

24 

Jae SY, Carnethon MR, Heffernan KS, Fernhall B, Lee MK and Park WH: Heart rate recovery after exercise and incidence of type 2 diabetes in men. Clin Auton Res. 19:189–192. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Cheng YJ, Lauer MS, Earnest CP, Church TS, Kampert JB, Gibbons LW and Blair SN: Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. Diabetes Care. 26:2052–2057. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Georgoulias P, Demakopoulos N, Orfanakis A, Xydis K, Xaplanteris P, Vardas P and Fezoulidis I: Evaluation of abnormal heart-rate recovery after exercise testing in patients with diabetes mellitus: correlation with myocardial SPECT and chronotropic parameters. Nucl Med Commun. 28:165–171. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Georgoulias P, Demakopoulos N, Valotassiou V, Orfanakis A, Zaganides A, Tsougos I and Fezoulidis I: Long-term prognostic value of heart-rate recovery after treadmill testing in patients with diabetes mellitus. Int J Cardiol. 134:67–74. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Li J, Chen W and Gao M: Effect of individualized exercise on cardiac autonomic nerve function. J Chinese Modern Med. 16:27–31. 2014.(In Chinese).

29 

Ribisl PM, Gaussoin SA, Lang W, Bahnson J, Connelly SA, Horton ES, Jakicic JM, Killean T, Kitzman DW, Knowler WC, et al: Look AHEAD Research Group: Lifestyle intervention improves heart rate recovery from exercise in adults with type 2 diabetes: results from the Look AHEAD study. J Obes. 2012:3091962012. View Article : Google Scholar : PubMed/NCBI

30 

Schwarz PE, Lindström J, Kissimova-Scarbeck K, Szybinski Z, Barengo NC, Peltonen M and Tuomilehto J: DE-PLAN project: The European perspective of type 2 diabetes prevention: diabetes in Europe - prevention using lifestyle, physical activity and nutritional intervention (DE-PLAN) project. Exp Clin Endocrinol Diabetes. 116:167–172. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Church TS, LaMonte MJ, Barlow CE and Blair SN: Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med. 165:2114–2120. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Albright A, Franz M, Hornsby G, Kriska A, Marrero D, Ullrich I and Verity LS: American College of Sports Medicine position stand. Exercise and type 2 diabetes. Med Sci Sports Exerc. 32:1345–1360. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Pagkalos M, Koutlianos N, Kouidi E, Pagkalos E, Mandroukas K and Deligiannis A: Heart rate variability modifications following exercise training in type 2 diabetic patients with definite cardiac autonomic neuropathy. Br J Sports Med. 42:47–54. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Hedelin R, Bjerle P and Henriksson-Larsén K: Heart rate variability in athletes: relationship with central and peripheral performance. Med Sci Sports Exerc. 33:1394–1398. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Reitman JS, Vasquez B, Klimes I and Nagulesparan M: Improvement of glucose homeostasis after exercise training in non-insulin-dependent diabetes. Diabetes Care. 7:434–441. 1984. View Article : Google Scholar : PubMed/NCBI

36 

Kraus WE and Levine BD: Exercise training for diabetes: The ‘strength’ of the evidence. Ann Intern Med. 147:423–424. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jin L, Min G, Wei C, Min H and Jie Z: Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus. Exp Ther Med 13: 899-904, 2017.
APA
Jin, L., Min, G., Wei, C., Min, H., & Jie, Z. (2017). Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 13, 899-904. https://doi.org/10.3892/etm.2017.4084
MLA
Jin, L., Min, G., Wei, C., Min, H., Jie, Z."Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 13.3 (2017): 899-904.
Chicago
Jin, L., Min, G., Wei, C., Min, H., Jie, Z."Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 13, no. 3 (2017): 899-904. https://doi.org/10.3892/etm.2017.4084
Copy and paste a formatted citation
x
Spandidos Publications style
Jin L, Min G, Wei C, Min H and Jie Z: Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus. Exp Ther Med 13: 899-904, 2017.
APA
Jin, L., Min, G., Wei, C., Min, H., & Jie, Z. (2017). Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 13, 899-904. https://doi.org/10.3892/etm.2017.4084
MLA
Jin, L., Min, G., Wei, C., Min, H., Jie, Z."Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 13.3 (2017): 899-904.
Chicago
Jin, L., Min, G., Wei, C., Min, H., Jie, Z."Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 13, no. 3 (2017): 899-904. https://doi.org/10.3892/etm.2017.4084
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