Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2017 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2017 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell

  • Authors:
    • Shujie Gan
    • Shenlong Qiu
    • Yiwen Feng
    • Yanping Zhang
    • Qin Qian
    • Zhong Wan
    • Jingdong Tang
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, The First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, P.R. China, Department of Vascular Surgery, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai 201399, P.R. China
    Copyright: © Gan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1303-1312
    |
    Published online on: February 21, 2017
       https://doi.org/10.3892/etm.2017.4138
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Vascular smooth muscle cell (VSMC) accumulation and hypertrophy are common in vascular disorders, and inflammation has a crucial role in the development of these diseases. To investigate the effect of inflammation on the neurotransmission of VSMC, bioinformatic analysis was performed, following next generation sequencing. Genes of lipopolysaccharide (LPS)-treated A7r5 cells and phosphate‑buffered saline (PBS)‑treated A7r5 cells were sequenced via next generation sequencing, and each assay was repeated three times. Differentially expressed genes (DEGs) were obtained using the NOISeq package in R. Subsequently, their potential functions were predicted by functional and pathway enrichment analyses using the Database for Annotation, Visualization and Integrated Discovery online tool. Interaction relationships of the proteins enriched in pathways associated with neurological diseases, the proteins which had interaction relationships with adrenoceptor α 1D (ADRA1D) or calcium voltage‑gated channel subunit α1 S (CACNA1S), separately, were obtained from STRING, and protein‑protein interaction (PPI) networks were constructed using Cytoscape software. A total of 2,038 DEGs, including 1,094 upregulated and 944 downregulated genes in the LPS treatment group were identified when compared with the control group. Enrichment analyses showed that NADH:Ubiquinone Oxidoreductase Core Subunit V2 (NDUFV2) was involved in several neurological diseases, including oxidative phosphorylation, Alzheimer's disease, Parkinson's disease and Huntington's disease. Furthermore, NDUFV2 (degree, 20) had a higher degree in the PPI network for DEGs enriched in pathways associated with neurological diseases. In the PPI network for ADRA1D, CACNA1S and the DEGs interacting with them, prohibitin (PHB), oxytocin receptor (OXTR), collapsin response mediator protein 1 (CRMP1) and dihydropyrimidinase like 2 (DPYSL2) had interaction relationships with both ADRA1D and CACNA1S. To conclude, the present study revealed that NDUFV2, PHB, OXTR, CRMP1 and DPYSL2 may have key roles in the effect of inflammation on neurotransmission of VSMC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Owens GK: Regulation of differentiation of vascular smooth muscle cells. Physiol Rev. 75:487–517. 1995.PubMed/NCBI

2 

Fukata Y, Amano M and Kaibuchi K: Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci. 22:32–39. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, Kumada M, Hotta K, Nishida M, Takahashi M, et al: Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 105:2893–2898. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Heo SK, Yun HJ, Noh EK, Park WH and Park SD: LPS induces inflammatory responses in human aortic vascular smooth muscle cells via Toll-like receptor 4 expression and nitric oxide production. Immunol Lett. 120:57–64. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Irani K: Oxidant signaling in vascular cell growth, death, and survival a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res. 87:179–183. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Eltzschig HK and Carmeliet P: Hypoxia and inflammation. N Engl J Med. 364:656–665. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Deten A, Volz HC, Holzl A, Briest W and Zimmer HG: Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. Mol Cell Biochem. 251:127–137. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Davel AP, Fukuda LE, De Sá LL, Munhoz CD, Scavone C, Sanz-Rosa D, Cachofeiro V, Lahera V and Rossoni LV: Effects of isoproterenol treatment for 7 days on inflammatory mediators in the rat aorta. Am J Physiol Heart Circ Physiol. 295:H211–H219. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Zhu Y, Tuerxun A, Hui Y and Abliz P: Effects of propranolol and isoproterenol on infantile hemangioma endothelial cells in vitro. Exp Ther Med. 8:647–651. 2014.PubMed/NCBI

10 

Romacho T, Azcutia V, Vázquez-Bella M, Matesanz N, Cercas E, Nevado J, Carraro R, Rodríguez-Mañas L, Sánchez-Ferrer CF and Peiró C: Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity. Diabetologia. 52:2455–2463. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Cuff CA, Kothapalli D, Azonobi I, Chun S, Zhang Y, Belkin R, Yeh C, Secreto A, Assoian RK, Rader DJ and Puré E: The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Invest. 108:10312001. View Article : Google Scholar : PubMed/NCBI

12 

Dichtl W, Dulak J, Frick M, Alber HF, Schwarzacher SP, Ares MP, Nilsson J, Pachinger O and Weidinger F: HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 23:58–63. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Christodoulou DC, Gorham JM, Herman DS and Seidman J: Construction of normalized RNA-seq libraries for next-generation sequencing using the crab duplex-specific nuclease. Curr Protoc Mol Biol Chapter. 4:Unit4.12. 2011. View Article : Google Scholar

14 

Trapnell C, Pachter L and Salzberg SL: TopHat: Discovering splice junctions with RNA-Seq. Bioinformatics. 25:1105–1111. 2009. View Article : Google Scholar : PubMed/NCBI

15 

D'Antonio M, Picardi E, Castrignanò T, D'Erchia AM and Pesole G: Exploring the RNA editing potential of RNA-Seq data by ExpEdit. Methods Mol Biol. 1269:327–328. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL and Pachter L: Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc. 7:562–578. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Tarazona S, Furio-Tari P, Ferrer A and Conesa A: NOISeq: Exploratory analysis and differential expression for RNA-seq data. R package version 200. 2012.

18 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nature genetics. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Altermann E and Klaenhammer TR: PathwayVoyager: Pathway mapping using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. BMC Genomics. 6:602005. View Article : Google Scholar : PubMed/NCBI

20 

da W Huang, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2008. View Article : Google Scholar

21 

Snel B, Lehmann G, Bork P and Huynen MA: STRING: A web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res. 28:3442–3444. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Willoughby D, Dunn C, Yamamoto S, Capasso F, Deporter D and Giroud J: Calcium pyrophosphate-induced pleurisy in rats: A new model of acute inflammation. 1975. Agents Actions. 43:221–224. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Nishioka K, Vilariño-Güell C, Cobb SA, Kachergus JM, Ross OA, Hentati E, Hentati F and Farrer MJ: Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson's disease. Parkinsonism Relat Disord. 16:686–687. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Washizuka S, Kametani M, Sasaki T, Tochigi M, Umekage T, Kohda K and Kato T: Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with schizophrenia in the Japanese population. Am J Med Genet B Neuropsychiatr Genet. 141B:301–304. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Liu HY, Liao PC, Chuang KT and Kao MC: Mitochondrial targeting of human NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy. J Biomed Sci. 18:292011. View Article : Google Scholar : PubMed/NCBI

27 

Teoh J, Boulos S, Chieng J, Knuckey NW and Meloni BP: Over-expressing prohibitin (PHB) in neuronal cultures exacerbates cell death following hydrogen peroxide and L-glutamic acid induced injury. Neurosci Med. 5:149–160. 2014. View Article : Google Scholar

28 

Muraguchi T, Kawawa A and Kubota S: Prohibitin protects against hypoxia-induced H9c2 cardiomyocyte cell death. Biomed Res. 31:113–122. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T and Koike K: Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein. Hepatology. 50:378–386. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Amrani Y, Syed F, Huang C, Li K, Liu V, Jain D, Keslacy S, Sims MW, Baidouri H, Cooper PR, et al: Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13. Respir Res. 11:1042010. View Article : Google Scholar : PubMed/NCBI

31 

Kimura T, Tanizawa O, Mori K, Brownstein MJ and Okayama H: Structure and expression of a human oxytocin receptor. Nature. 356:3561992. View Article : Google Scholar : PubMed/NCBI

32 

Heinrichs M, Baumgartner T, Kirschbaum C and Ehlert U: Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry. 54:1389–1398. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Thompson RJ, Parker KJ, Hallmayer JF, Waugh CE and Gotlib IH: Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology. 36:144–147. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Li K, Qi Y, Xia T, Yao Y, Zhou L, Lau KM and Ng HK: CRMP1 inhibits proliferation of medulloblastoma and is regulated by HMGA1. PLoS One. 10:e01279102015. View Article : Google Scholar : PubMed/NCBI

35 

Yao L, Liu YH, Li X, Ji YH, Yang XJ, Hang XT, Ding ZM, Liu F, Wang YH and Shen AG: CRMP1 interacted with Spy1 during the collapse of growth cones induced by Sema3A and acted on regeneration after sciatic nerve crush. Mol Neurobiol. 53:879–893. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Indraswari F, Wong PT, Yap E, Ng YK and Dheen ST: Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Neurochem Int. 55:235–242. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Tanaka H, Morimura R and Ohshima T: Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish. Dev Biol. 370:223–236. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Xiong T, Tang J, Zhao J, Chen H, Zhao F, Li J, Qu Y, Ferriero D and Mu D: Involvement of the Akt/GSK-3β/CRMP-2 pathway in axonal injury after hypoxic-ischemic brain damage in neonatal rat. Neuroscience. 216:123–132. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Zhang CY, Feng SJ, Xu L, Bu XN, Zhang N, Zheng YX, Yuan XW, Li XG and Li JF: CRMP-2 is involved in hypoxic preconditioning-induced neuroprotection against cerebral ischemic injuries of mice. Chin J Basic Clin Med. 11:0072009.(In Chinese).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gan S, Qiu S, Feng Y, Zhang Y, Qian Q, Wan Z and Tang J: Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell. Exp Ther Med 13: 1303-1312, 2017.
APA
Gan, S., Qiu, S., Feng, Y., Zhang, Y., Qian, Q., Wan, Z., & Tang, J. (2017). Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell. Experimental and Therapeutic Medicine, 13, 1303-1312. https://doi.org/10.3892/etm.2017.4138
MLA
Gan, S., Qiu, S., Feng, Y., Zhang, Y., Qian, Q., Wan, Z., Tang, J."Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell". Experimental and Therapeutic Medicine 13.4 (2017): 1303-1312.
Chicago
Gan, S., Qiu, S., Feng, Y., Zhang, Y., Qian, Q., Wan, Z., Tang, J."Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1303-1312. https://doi.org/10.3892/etm.2017.4138
Copy and paste a formatted citation
x
Spandidos Publications style
Gan S, Qiu S, Feng Y, Zhang Y, Qian Q, Wan Z and Tang J: Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell. Exp Ther Med 13: 1303-1312, 2017.
APA
Gan, S., Qiu, S., Feng, Y., Zhang, Y., Qian, Q., Wan, Z., & Tang, J. (2017). Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell. Experimental and Therapeutic Medicine, 13, 1303-1312. https://doi.org/10.3892/etm.2017.4138
MLA
Gan, S., Qiu, S., Feng, Y., Zhang, Y., Qian, Q., Wan, Z., Tang, J."Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell". Experimental and Therapeutic Medicine 13.4 (2017): 1303-1312.
Chicago
Gan, S., Qiu, S., Feng, Y., Zhang, Y., Qian, Q., Wan, Z., Tang, J."Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1303-1312. https://doi.org/10.3892/etm.2017.4138
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team