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Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model

  • Authors:
    • Şeref Ezirganli
    • Hakki Oğuz Kazancioğlu
    • Ahmet Hüseyin Acar
    • Hakan Özdemir
    • Emre Kuzu
    • Deniz Şahin İnan
  • View Affiliations / Copyright

    Affiliations: Program of Dental Assisting, Vocational School of Health Services, Institute of Health Science, Nişantası University, Bayrampaşa, 34030 Istanbul, Turkey, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, Fatih, 34093 Istanbul, Turkey, Department of Periodontology, Faculty of Dentistry, Osmangazi University, 26480 Eskişehir, Turkey, Dental Health Centre of Sivas, Rebublic of Turkey Ministry of Health, 58020 Sivas, Turkey, Department of Histology and Embryology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
    Copyright: © Ezirganli et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1827-1831
    |
    Published online on: March 1, 2017
       https://doi.org/10.3892/etm.2017.4166
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Abstract

Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma or infection represent a significant and common clinical problem. The present study aimed to evaluate the effects of a commercially-available medicinal plant extract product, Ankaferd BloodStopper (ABS), on bone healing. The present study was performed on 24 female ovariectomized (OVX) rats. A defect on each rat calvarium was created using a trephine burr prior to the rats being divided into two groups. Defects were grafted with a gelatin sponge soaked with normal saline (control group) or plant extract (experimental group). Half of the animals were sacrificed after 2 weeks and the others after 4 weeks. In the control group, the defects were not filled with regenerated bone. By contrast, in the experimental group, all defect areas had an increased amount of regenerated bone and connective tissue. Osteoblastic activity appeared to be greater in the experimental group however, osteoclastic activity was observed to be higher in the control group. At 2 and 4 weeks, there was a significant difference in the amount of newly regenerated bone observed in the experimental group compared with the control group (P<0.05). Therefore, the results of the present study indicated that local ABS application had a positive effect on bone healing in the OVX rat model.
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1 

Terella A, Mariner P, Brown N, Anseth K and Streubel SO: Repair of a calvarial defect with biofactor and stem cell-embedded polyethylene glycol scaffold. Arch Facial Plast Surg. 12:166–171. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Ezirganlı Ş, Polat S, Barış E, Tatar İ and Çelik HH: Comparative investigation of the effects of different materials used with a titanium barrier on new bone formation. Clin Oral Implants Res. 24:312–319. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Rubin JP and Yaremchuk MJ: Complications and toxicities of implantable biomaterials used in facial reconstructive and aesthetic surgery: A comprehensive review of the literature. Plast Reconstr Surg. 100:1336–1353. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Choi JY, Jung UW, Kim CS, Eom TK, Kang EJ, Cho KS, Kim CK and Choi SH: The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects. J Periodontal Implant Sci. 40:11–18. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Toker H, Ozdemir H, Ozer H and Eren K: Alendronate enhances osseous healing in a rat calvarial defect model. Arch Oral Biol. 57:1545–1550. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Acar AH, Yolcu Ü, Gül M, Keleş A, Erdem NF and Altundag Kahraman S: Micro-computed tomography and histomorphometric analysis of the effects of platelet-rich fibrin on bone regeneration in the rabbit calvarium. Arch Oral Biol. 60:606–614. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Acar AH, Yolcu Ü, Altındiş S, Gül M, Alan H and Malkoç S: Bone regeneration by low-level laser therapy and low-intensity pulsed ultrasound therapy in the rabbit calvarium. Arch Oral Biol. 61:60–65. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Guney A, Karaman I, Oner M and Yerer MB: Effects of propolis on fracture healing: An experimental study. Phytother Res. 25:1648–1652. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kirui PK, Cameron J, Benghuzzi HA, Tucci M, Patel R, Adah F and Russell G: Effects of sustained delivery of thymoqiunone on bone healing of male rats. Biomed Sci Instrum. 40:111–116. 2004.PubMed/NCBI

10 

Duygulu F, Yakan B, Karaoglu S, Kutlubay R, Karahan OI and Ozturk A: The effect of zymosan and the protective effect of various antioxidants on fracture healing in rats. Arch Orthop Trauma Surg. 127:493–501. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Işler SC, Demircan S, Cakarer S, Cebi Z, Keskin C, Soluk M and Yüzbaşioğlu E: Effects of folk medicinal plant extract Ankaferd Blood Stopper on early bone healing. J Appl Oral Sci. 18:409–414. 2010.PubMed/NCBI

12 

Kazancıoğlu HO, Cakır O, Ak G and Zülfikar B: The effectiveness of a new hemostatic agent (ankaferd blood stopper) for the control of bleeding following tooth extraction in Hemophilia: A controlled clinical trial. Turk J Haematol. 30:19–24. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Tamimi FM, Torres J, Tresguerres I, Clemente C, López-Cabarcos E and Blanco LJ: Bone augmentation in rabbit calvariae: Comparative study between Bio-Oss and a novel beta-TCP/DCPD granulate. J Clin Periodontol. 33:922–928. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Akimoto K, Becker W, Donath K, Becker BE and Sanchez R: Formation of bone around titanium implants placed into zero wall defects: Pilot project using reinforced e-PTFE membrane and autogenous bone grafts. Clin Implant Dent Relat Res. 1:98–104. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Comelekoglu U, Bagis S, Yalin S, Ogenler O, Yildiz A, Sahin NO, Oguz I and Hatungil R: Biomechanical evaluation in osteoporosis: Ovariectomized rat model. Clin Rheumatol. 26:380–384. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Kalu DN: The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15:175–191. 1991. View Article : Google Scholar : PubMed/NCBI

17 

Herron S, Thordarson DB, Winet H, Luk A and Bao JY: Ingrowth of bone into absorbable bone cement: An in vivo microscopic evaluation. Am J Orthop (Belle Mead NJ). 32:581–584. 2003.PubMed/NCBI

18 

Luize DS, Bosco AF, Bonfante S and de Almeida JM: Influence of ovariectomy on healing of autogenous bone block grafts in the mandible: A histomorphometric study in an aged rat model. Int J Oral Maxillofac Implants. 23:207–214. 2008.PubMed/NCBI

19 

Thorwarth M, Schultze-Mosgau S, Wehrhan F, Kessler P, Srour S, Wiltfang J and Schlegel Andrea K: Bioactivation of an anorganic bone matrix by P-15 peptide for the promotion of early bone formation. Biomaterials. 26:5648–5657. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Merkx MA, Maltha JC, Freihofer HP and Kuijpers-Jagtman AM: Incorporation of particulated bone implants in the facial skeleton. Biomaterials. 20:2029–2035. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Maeda T, Kawane T and Horiuchi N: Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology. 144:681–692. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Nyan M, Miyahara T, Noritake K, Hao J, Rodriguez R, Kuroda S and Kasugai S: Molecular and tissue responses in the healing of rat calvarial defects after local application of simvastatin combined with alpha tricalcium phosphate. J Biomed Mater Res B Appl Biomater. 93:65–73. 2010.PubMed/NCBI

23 

Ezirganli S, Kazancıoğlu HO, Mihmanli A, Aydin MS, Sharifov R and Alkan A: The effect of local simvastatin application on critical size defects in the diabetic rats. Clin Oral Implants Res. 25:969–976. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Goker H, Haznedaroglu IC, Ercetin S, Kirazli S, Akman U, Ozturk Y and Firat HC: Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper. J Int Med Res. 36:163–170. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Leblebisatan G, Bay A, Karakus SC, Kekilli M and Haznedaroglu IC: Topical Ankaferd hemostat application for the management of oral cavity bleedings in children with hemorrhagic diathesis. Blood Coagul Fibrinolysis. 23:494–497. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ezirganli Ş, Kazancioğlu HO, Acar AH, Özdemir H, Kuzu E and İnan DŞ: Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model. Exp Ther Med 13: 1827-1831, 2017.
APA
Ezirganli, Ş., Kazancioğlu, H.O., Acar, A.H., Özdemir, H., Kuzu, E., & İnan, D.Ş. (2017). Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model. Experimental and Therapeutic Medicine, 13, 1827-1831. https://doi.org/10.3892/etm.2017.4166
MLA
Ezirganli, Ş., Kazancioğlu, H. O., Acar, A. H., Özdemir, H., Kuzu, E., İnan, D. Ş."Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model". Experimental and Therapeutic Medicine 13.5 (2017): 1827-1831.
Chicago
Ezirganli, Ş., Kazancioğlu, H. O., Acar, A. H., Özdemir, H., Kuzu, E., İnan, D. Ş."Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1827-1831. https://doi.org/10.3892/etm.2017.4166
Copy and paste a formatted citation
x
Spandidos Publications style
Ezirganli Ş, Kazancioğlu HO, Acar AH, Özdemir H, Kuzu E and İnan DŞ: Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model. Exp Ther Med 13: 1827-1831, 2017.
APA
Ezirganli, Ş., Kazancioğlu, H.O., Acar, A.H., Özdemir, H., Kuzu, E., & İnan, D.Ş. (2017). Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model. Experimental and Therapeutic Medicine, 13, 1827-1831. https://doi.org/10.3892/etm.2017.4166
MLA
Ezirganli, Ş., Kazancioğlu, H. O., Acar, A. H., Özdemir, H., Kuzu, E., İnan, D. Ş."Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model". Experimental and Therapeutic Medicine 13.5 (2017): 1827-1831.
Chicago
Ezirganli, Ş., Kazancioğlu, H. O., Acar, A. H., Özdemir, H., Kuzu, E., İnan, D. Ş."Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1827-1831. https://doi.org/10.3892/etm.2017.4166
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