Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical study on the association between pregnancy-induced hypertension and insulin resistance

  • Authors:
    • Zhifang Chen
    • Weiling Liu
    • Xiaoqin Sun
    • Lingling Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nantong Maternity and Child Health Care Hospital Affiliated to Nantong University, Nantong, Jiangsu 226018, P.R. China
  • Pages: 2065-2070
    |
    Published online on: March 2, 2017
       https://doi.org/10.3892/etm.2017.4169
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to explore the association between pregnancy-induced hypertension (PIH) and insulin resistance (IR). A total of 50 cases of PIH and 50 healthy pregnant women with a similar gestational age were enrolled. The hyperinsulinemic-euglycemic clamp technique was used to evaluate the degree of IR and all 100 subjects were divided into an IR and a non‑IR group accordingly. Subsequently, the correlation between the systolic or diastolic blood pressure was assessed; furthermore, a homeostasis model assessment of IR (HOMA‑IR), a HOMA of the insulin sensitivity index (HOMA‑ISI) and a HOMA of β cell function (HOMA‑β%) were performed. Moreover, the effect of IR on PIH was assessed and the protein expression of insulin receptor substrate (IRS)‑1, phosphorylated (p)‑IRS‑1, AKT and p‑AKT were detected in the placental plasma by western blot analysis. The results showed that in the PIH group, the p‑IRS‑1/IRS‑1 and p-AKT/AKT ratios were decreased compared with those in the control group. Blood flow parameters, including perfusion index, retinal resistive index and systolic maximum velocity/end‑diastolic velocity ratio in the IR group were higher, while time averaged velocity was lower compared with that in the non‑IR group. Furthermore, the HOMA‑ISI and HOMA‑β% were decreased, while the HOMA‑IR was increased in the PIH group compared to that in the control group; alongside the blockage of the insulin signaling pathway, these factors may therefore cause PIH. The present study may provide novel therapeutic approaches for PIH.
View Figures

Figure 1

View References

1 

Salge AK, Xavier RM, Ramalho WS, Rocha EL, Coelho AS, Guimarães JV, Siqueira KM, Abdalla DR, Michelin MA and Murta EF: Placental and umbilical cord macroscopic changes associated with fetal and maternal events in the hypertensive disorders of pregnancy. Clin Exp Obstet Gynecol. 40:198–202. 2013.PubMed/NCBI

2 

Flores KF, Robledo CA, Hwang BS, Leishear K, Grantz Laughon K and Mendola P: Does maternal asthma contribute to racial/ethnic disparities in obstetrical and neonatal complications? Ann Epidemiol. 25:392–397. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Yang JJ, Lee SA, Choi JY, Song M, Han S, Yoon HS, Lee Y, Oh J, Lee JK and Kang D: Subsequent risk of metabolic syndrome in women with a history of preeclampsia: Data from the health examinees study. J Epidemiol. 25:281–288. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Walker CK, Krakowiak P, Baker A, Hansen RL, Ozonoff S and Hertz-Picciotto I: Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay. JAMA Pediatr. 169:154–162. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Katulski K, Czyzyk A, Podfigurna-Stopa A, Genazzani AR and Meczekalski B: Pregnancy complications in polycystic ovary syndrome patients. Gynecol Endocrinol. 31:87–91. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Rahmanian M, Salari Z, Mirmohammadkhani M and Ghorbani R: Is the sex hormone binding globulin related to preeclampsia independent of insulin resistance? J Pak Med Assoc. 64:640–643. 2014.PubMed/NCBI

7 

Tuuri AL, Jauhiainen MS, Tikkanen MJ and Kaaja RJ: Systolic blood pressure and fatty acid-binding protein 4 predict pregnancy-induced hypertension in overweight nulliparous women. Placenta. 35:797–801. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Abhari FR, Andarieh Ghanbari M, Farokhfar A and Ahmady S: Estimating rate of insulin resistance in patients with preeclampsia using HOMA-IR index and comparison with nonpreeclampsia pregnant women. Biomed Res Int. 2014:1408512014. View Article : Google Scholar : PubMed/NCBI

9 

Zhang H, Zhao D, Shen J, Zhou X, Chen W and Jiang S: Evaluation of oral glucose tolerance test, β-cell function and adverse obstetric outcomes. Biomed Rep. 1:807–811. 2013.PubMed/NCBI

10 

Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol. 183:S1–S22. 2000. View Article : Google Scholar

11 

Cunningham FG, Gant NF, Leveno KJ, Gilstrap LC, Hauth JC, Wenstrom KD, Werner CL and Cox SM: Williams Obstetrics. 21st. McGraw-Hill; New York, NY: 2001

12 

Sahasrabuddhe A, Pitale S, Raje D and Sagdeo MM: Cord blood levels of insulin and glucose in full-term pregnancies. J Assoc Physicians India. 61:378–382. 2013.PubMed/NCBI

13 

Mastrogiannis DS, Spiliopoulos M, Mulla W and Homko CJ: Insulin resistance: The possible link between gestational diabetes mellitus and hypertensive disorders of pregnancy. Curr Diab Rep. 9:296–302. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Garcés MF, Peralta JJ, Ruiz-Linares CE, Lozano AR, Poveda NE, Torres-Sierra AL, Eslava-Schmalbach JH, Alzate JP, Sánchez AY, Sanchez E, et al: Irisin levels during pregnancy and changes associated with the development of preeclampsia. J Clin Endocrinol Metab. 99:2113–2119. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Huda SS, Forrest R, Paterson N, Jordan F, Sattar N and Freeman DJ: In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy. Hypertension. 63:1094–1101. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Tran M, Gallo LA, Hanvey AN, Jefferies AJ, Westcott KT, Cullen-McEwen LA, Gardner DK, Moritz KM and Wlodek ME: Embryo transfer cannot delineate between the maternal pregnancy environment and germ line effects in the transgenerational transmission of disease in rats. Am J Physiol Regul Integr Comp Physiol. 306:R607–R618. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Valdés E, Sepúlveda-Martínez A, Manukián B and Parra-Cordero M: Assessment of pregestational insulin resistance as a risk factor of preeclampsia. Gynecol Obstet Invest. 77:111–116. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Lampinen KH, Rönnback M, Groop PH, Nicholls MG, Yandle TG and Kaaja RJ: Increased plasma norepinephrine levels in previously pre-eclamptic women. J Hum Hypertens. 28:269–273. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Scioscia M, Nigro M and Montagnani M: The putative metabolic role of d-chiro inositol phosphoglycan in human pregnancy and preeclampsia. J Reprod Immunol. 101–102:140–147. 2014. View Article : Google Scholar

20 

Tuuri AL, Jauhiainen MS, Ehnholm CP, Tikkanen MJ, Nicholls MG and Kaaja RJ: Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension: A preliminary study. Hypertens Pregnancy. 32:203–213. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Harper LM, Renth A, Cade WT, Colvin R, Macones GA and Cahill AG: Impact of obesity on maternal and neonatal outcomes in insulin-resistant pregnancy. Am J Perinatol. 31:383–388. 2014.PubMed/NCBI

22 

Romero J and Spinedi E: Two-hour insulinemia after oral glucose overload and women at risk of pregnancy-induced hypertensive disorders. Hypertens Pregnancy. 32:355–366. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Oxenkrug G: Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways. Mol Neurobiol. 48:294–301. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Duehlmeier R, Noldt S and Ganter M: Pancreatic insulin release and peripheral insulin sensitivity in German black headed mutton and Finish Landrace ewes: Evaluation of the role of insulin resistance in the susceptibility to ovine pregnancy toxemia. Domest Anim Endocrinol. 44:213–221. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Duehlmeier R, Fluegge I, Schwert B and Ganter M: Insulin sensitivity during late gestation in ewes affected by pregnancy toxemia and in ewes with high and low susceptibility to this disorder. J Vet Intern Med. 27:359–366. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Kayemba-Kay's S, Peters C, Geary MP, Hill NR, Mathews DR and Hindmarsh PC: Maternal hyperinsulinism and glycaemic status in the first trimester of pregnancy are associated with the development of pregnancy-induced hypertension and gestational diabetes. Eur J Endocrinol. 168:413–418. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Smith GN, Pudwell J, Walker M and Wen SW: Risk estimation of metabolic syndrome at one and three years after a pregnancy complicated by preeclampsia. J Obstet Gynaecol Can. 34:836–841. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Spaan JJ, Sep SJ, van Balen VL, Spaanderman ME and Peeters LL: Metabolic syndrome as a risk factor for hypertension after preeclampsia. Obstet Gynecol. 120:311–317. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen Z, Liu W, Sun X and Zhu L: Clinical study on the association between pregnancy-induced hypertension and insulin resistance. Exp Ther Med 13: 2065-2070, 2017.
APA
Chen, Z., Liu, W., Sun, X., & Zhu, L. (2017). Clinical study on the association between pregnancy-induced hypertension and insulin resistance. Experimental and Therapeutic Medicine, 13, 2065-2070. https://doi.org/10.3892/etm.2017.4169
MLA
Chen, Z., Liu, W., Sun, X., Zhu, L."Clinical study on the association between pregnancy-induced hypertension and insulin resistance". Experimental and Therapeutic Medicine 13.5 (2017): 2065-2070.
Chicago
Chen, Z., Liu, W., Sun, X., Zhu, L."Clinical study on the association between pregnancy-induced hypertension and insulin resistance". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2065-2070. https://doi.org/10.3892/etm.2017.4169
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Z, Liu W, Sun X and Zhu L: Clinical study on the association between pregnancy-induced hypertension and insulin resistance. Exp Ther Med 13: 2065-2070, 2017.
APA
Chen, Z., Liu, W., Sun, X., & Zhu, L. (2017). Clinical study on the association between pregnancy-induced hypertension and insulin resistance. Experimental and Therapeutic Medicine, 13, 2065-2070. https://doi.org/10.3892/etm.2017.4169
MLA
Chen, Z., Liu, W., Sun, X., Zhu, L."Clinical study on the association between pregnancy-induced hypertension and insulin resistance". Experimental and Therapeutic Medicine 13.5 (2017): 2065-2070.
Chicago
Chen, Z., Liu, W., Sun, X., Zhu, L."Clinical study on the association between pregnancy-induced hypertension and insulin resistance". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2065-2070. https://doi.org/10.3892/etm.2017.4169
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team