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Article

Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats

  • Authors:
    • Myung‑Joo Choi
    • Hong‑Mei Zheng
    • Hee Dong Park
    • Hee Kyung Jeong
    • Soon‑Sun Hong
    • Jae Min Kim
    • Don Haeng Lee
  • View Affiliations / Copyright

    Affiliations: Department of New Drug Development, College of Medicine, Inha University, Incheon 22332, Republic of Korea, LG Life Sciences, Ltd., R&D Center, Yuseong‑gu, Daejeon 34122, Republic of Korea, National Centre of Efficacy Evaluation for The Development of Health Products, Inha University Hospital, Jung‑gu, Incheon 22332, Republic of Korea
  • Pages: 2043-2049
    |
    Published online on: March 6, 2017
       https://doi.org/10.3892/etm.2017.4185
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Abstract

LD02GIFRO is a novel prokinetic agent formulated with Poncirus fructus and Zanthoxylum sp. fruits. The aim of the present study was to evaluate the effect of LD02GIFRO on delayed gastrointestinal transit (GIT) and colorectal hypersensitivity. To investigate the effect of LD02GIFRO, a rat model of delayed GIT was induced via three mechanisms; postoperative ileus (POI), morphine, and POI plus morphine. Visceromotor responses (VMR) to colorectal distension (CRD) were also evaluated. POI was induced by laparotomy surgery and manipulation of the small intestine under anesthesia, and GIT was calculated by measuring the length that Evans Blue travelled through the gastrointestinal tract in a given time. Oral administration of 260 mg/kg LD02GIFRO caused Evans Blue to migrate significantly further in the delayed GIT models induced by POI, morphine and POI plus morphine compared with the control (P<0.05). This effect was inhibited by atropine, a muscarinic receptor antagonist, and completely abolished by GR125487, a 5‑HT4‑receptor antagonist. Furthermore, intraperitoneal administration of 600 and 900 mg/kg LD02GIFRO significantly reduced VMR to CRD in acute and chronic colorectal hypersensitive rat models, induced by acetic acid and trinitrobenzenesulfonic acid, to almost normal levels (P<0.01). In the present study, LD02GIFRO successfully ameliorated delayed GIT models and colorectal hypersensitivity models, suggesting that LD02GIFRO may be an effective therapeutic treatment for patients with functional gastrointestinal disorders and abnormalities in GIT.
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Copy and paste a formatted citation
Spandidos Publications style
Choi MJ, Zheng HM, Park HD, Jeong HK, Hong SS, Kim JM and Lee DH: Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats. Exp Ther Med 13: 2043-2049, 2017.
APA
Choi, M., Zheng, H., Park, H.D., Jeong, H.K., Hong, S., Kim, J.M., & Lee, D.H. (2017). Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats. Experimental and Therapeutic Medicine, 13, 2043-2049. https://doi.org/10.3892/etm.2017.4185
MLA
Choi, M., Zheng, H., Park, H. D., Jeong, H. K., Hong, S., Kim, J. M., Lee, D. H."Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats". Experimental and Therapeutic Medicine 13.5 (2017): 2043-2049.
Chicago
Choi, M., Zheng, H., Park, H. D., Jeong, H. K., Hong, S., Kim, J. M., Lee, D. H."Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2043-2049. https://doi.org/10.3892/etm.2017.4185
Copy and paste a formatted citation
x
Spandidos Publications style
Choi MJ, Zheng HM, Park HD, Jeong HK, Hong SS, Kim JM and Lee DH: Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats. Exp Ther Med 13: 2043-2049, 2017.
APA
Choi, M., Zheng, H., Park, H.D., Jeong, H.K., Hong, S., Kim, J.M., & Lee, D.H. (2017). Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats. Experimental and Therapeutic Medicine, 13, 2043-2049. https://doi.org/10.3892/etm.2017.4185
MLA
Choi, M., Zheng, H., Park, H. D., Jeong, H. K., Hong, S., Kim, J. M., Lee, D. H."Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats". Experimental and Therapeutic Medicine 13.5 (2017): 2043-2049.
Chicago
Choi, M., Zheng, H., Park, H. D., Jeong, H. K., Hong, S., Kim, J. M., Lee, D. H."Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2043-2049. https://doi.org/10.3892/etm.2017.4185
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