Open Access

Association of Mycoplasma pneumoniae infection with increased risk of asthma in children

  • Authors:
    • Sha-Sha Yin
    • Feng-Lian Ma
    • Xing Gao
  • View Affiliations

  • Published online on: March 10, 2017     https://doi.org/10.3892/etm.2017.4219
  • Pages: 1813-1819
  • Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study was conducted to investigate the relationship between Mycoplasma pneumoniae (MP) infection and the risk of asthma among children by detecting the rate of MP immunoglobulin M (MP-IgM) and the eosinophil (EOS) count. A total of 139 asthmatic children were enrolled as the case group and assigned into three groups: Group A (aged <3 years, n=42), group B (aged 3-8 years, n=45) and group C (aged >8 years, n=52). Additionally, 115 healthy children were enrolled in the control group. Enzyme-linked immunosorbent assay was used to measure the MP-IgM‑positive rate. EOS count was detected in the experimental and control groups by using a hemocytometer analyzer. A meta-analysis was performed by using the Comprehensive Meta‑Analysis version 2.0 software. The positive rates of the MP-IgM and EOS count in the experimental group were significantly higher than those in control group (both P<0.001). Furthermore, the asthmatic children in group C had a higher MP-IgM‑positive rate and EOS count as compared to those in groups A and B, respectively (all P<0.05). Results from groups A and B were not statistically significant (all P>0.05). The meta-analysis further confirmed that asthmatic children had a higher MP-IgM‑positive rate as compared to the healthy controls (P<0.001). Age-stratified analysis revealed that the MP-IgM‑positive rate in asthmatic children aged ≥8 and <8 years was significantly higher than that in the healthy controls (P=0.003 and P<0.001). Asthmatic children had a higher MP-IgM-positive rate and EOS count as compared with controls, suggesting that the MP infection may be closely associated with the risk of asthma. Additionally, the positive rate of MP-IgM may indicate an important biological marker in predicting the development of asthma.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yin S, Ma F and Gao X: Association of Mycoplasma pneumoniae infection with increased risk of asthma in children. Exp Ther Med 13: 1813-1819, 2017
APA
Yin, S., Ma, F., & Gao, X. (2017). Association of Mycoplasma pneumoniae infection with increased risk of asthma in children. Experimental and Therapeutic Medicine, 13, 1813-1819. https://doi.org/10.3892/etm.2017.4219
MLA
Yin, S., Ma, F., Gao, X."Association of Mycoplasma pneumoniae infection with increased risk of asthma in children". Experimental and Therapeutic Medicine 13.5 (2017): 1813-1819.
Chicago
Yin, S., Ma, F., Gao, X."Association of Mycoplasma pneumoniae infection with increased risk of asthma in children". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1813-1819. https://doi.org/10.3892/etm.2017.4219