Effects of negative-pressure wound therapy combined with microplasma on treating wounds of ulcer and the expression of heat shock protein 90 Retraction in /10.3892/etm.2025.12881

Li,Zhihong; Wang,Qihong; Mi,Wenxin; Han,Mei; Gao,Fei; Niu,Guangyan; Ma,Yindong

doi:10.3892/etm.2017.4266

May-2017 Volume 13 Issue 5

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May-2017 Volume 13 Issue 5

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Article Open Access

Effects of negative-pressure wound therapy combined with microplasma on treating wounds of ulcer and the expression of heat shock protein 90

Retraction in: /10.3892/etm.2025.12881

Authors:
- Zhihong Li
- Qihong Wang
- Wenxin Mi
- Mei Han
- Fei Gao
- Guangyan Niu
- Yindong Ma
View Affiliations / Copyright

Affiliations: Department of Burns Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China

Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2211-2216
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Published online on: March 27, 2017

https://doi.org/10.3892/etm.2017.4266
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Abstract

The effects of negative pressure wound therapy (NPWT) combined with microplasma on treating wounds of ulcer, and blood perfusion of wound-healing of interface, angiogenesis and the expressions of heat shock protein 90 (HSP90) were explored. We selected continuously 64 patients with wounds of ulcer. The patients were divided into the conventional treatment group (just medical foam dressing and 1% silver sulfadiazine cream for dressing changes) (n=20 cases), the NPWT group (n=22 cases) and the combination group (NPWT combined with microplasma) (n=22 cases), and compared the effects. It was found that in the 7 and 14 day combination group, maturity of granulation tissues and growth degree of epithelium were significantly higher than those in other two groups, and the areas of ulcer reduced significantly, the healing rate increased significantly (P<0.05). In the 7 and 14 day combination group, blood perfusion of wounds and density of new vessels were significantly higher than the other two groups (P<0.05). In the 7 and 14 day combination group, the expression of HSP90 was significantly higher than the other two groups (P<0.05). In conclusion, NPWT combined with microplasma can improve the healing of woulds of ulcers, and it is related to the upregulated expression of HSP90.

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1	Ferreira MC, Carvalho VF, Kamamoto F, Tuma P Jr and Paggiaro AO: Negative pressure therapy (vacuum) for wound bed preparation among diabetic patients: case series. Sao Paulo Med J. 127:166–170. 2009. View Article : Google Scholar : PubMed/NCBI
2	Ferreira MC, Tuma P Jr, Carvalho VF and Kamamoto F: Complex wounds. Clinics (Sao Paulo). 61:571–578. 2006. View Article : Google Scholar : PubMed/NCBI
3	Rahmanian-Schwarz A, Willkomm LM, Gonser P, Hirt B and Schaller HE: A novel option in negative pressure wound therapy (NPWT) for chronic and acute wound care. Burns. 38:573–577. 2012. View Article : Google Scholar : PubMed/NCBI
4	Halachmi S, Orenstein A, Meneghel T and Lapidoth M: A novel fractional micro-plasma radio-frequency technology for the treatment of facial scars and rhytids: a pilot study. J Cosmet Laser Ther. 12:208–212. 2010. View Article : Google Scholar : PubMed/NCBI
5	Halim AS, Khoo TL and Saad AZ: Wound bed preparation from a clinical perspective. Indian J Plast Surg. 45:193–202. 2012. View Article : Google Scholar : PubMed/NCBI
6	Stojadinovic A, Carlson JW, Schultz GS, Davis TA and Elster EA: Topical advances in wound care. Gynecol Oncol. 111:(Suppl 2). S70–S80. 2008. View Article : Google Scholar : PubMed/NCBI
7	Lee HJ, Kim JW, Oh CW, Min WK, Shon OJ, Oh JK, Park BC and Ihn JC: Negative pressure wound therapy for soft tissue injuries around the foot and ankle. J Orthop Surg. 4:142009. View Article : Google Scholar
8	McCallon SK, Knight CA, Valiulus JP, Cunningham MW, McCulloch JM and Farinas LP: Vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds. Ostomy Wound Manage. 46:28–32, 34. 2000.PubMed/NCBI
9	Lancerotto L, Bayer LR and Orgill DP: Mechanisms of action of microdeformational wound therapy. Semin Cell Dev Biol. 23:987–992. 2012. View Article : Google Scholar : PubMed/NCBI
10	Kamolz LP, Andel H, Haslik W, Winter W, Meissl G and Frey M: Use of subatmospheric pressure therapy to prevent burn wound progression in human: first experiences. Burns. 30:253–258. 2004. View Article : Google Scholar : PubMed/NCBI
11	Simman R, Forte R and Silverberg R: A comparative histological pilot study of skin graft take with tie-over bolster dressing versus vacuum assisted closure in a pig model. Wounds. 16:76–80. 2004.
12	Lambert KV, Hayes P and McCarthy M: Vacuum assisted closure: a review of development and current applications. Eur J Vasc Endovasc Surg. 29:219–226. 2005. View Article : Google Scholar : PubMed/NCBI
13	Borgquist O, Anesäter E, Hedström E, Lee CK, Ingemansson R and Malmsjö M: Measurements of wound edge microvascular blood flow during negative pressure wound therapy using thermodiffusion and transcutaneous and invasive laser Doppler velocimetry. Wound Repair Regen. 19:727–733. 2011. View Article : Google Scholar : PubMed/NCBI
14	Baillot R, Cloutier D, Montalin L, Côté L, Lellouche F, Houde C, Gaudreau G and Voisine P: Impact of deep sternal wound infection management with vacuum-assisted closure therapy followed by sternal osteosynthesis: a 15-year review of 23,499 sternotomies. Eur J Cardiothorac Surg. 37:880–887. 2010. View Article : Google Scholar : PubMed/NCBI
15	Kairinos N, Solomons M and Hudson DA: The paradox of negative pressure wound therapy - in vitro studies. J Plast Reconstr Aesthet Surg. 63:174–179. 2010. View Article : Google Scholar : PubMed/NCBI
16	Torbrand C, Ugander M, Engblom H, Arheden H, Ingemansson R and Malmsjö M: Wound contraction and macro-deformation during negative pressure therapy of sternotomy wounds. J Cardiothorac Surg. 5:752010. View Article : Google Scholar : PubMed/NCBI
17	Scherer SS, Pietramaggiori G, Mathews JC and Orgill DP: Short periodic applications of the vacuum-assisted closure device cause an extended tissue response in the diabetic mouse model. Plast Reconstr Surg. 124:1458–1465. 2009. View Article : Google Scholar : PubMed/NCBI
18	Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D and Orgill DP: Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg. 114:1086–1096; discussion 1097–1098. 2004. View Article : Google Scholar : PubMed/NCBI
19	Jacobs S, Simhaee DA, Marsano A, Fomovsky GM, Niedt G and Wu JK: Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model. J Plast Reconstr Aesthet Surg. 62:1331–1338. 2009. View Article : Google Scholar : PubMed/NCBI
20	Elsaie ML and Kammer JN: Evaluation of plasma skin regeneration technology for cutaneous remodeling. J Cosmet Dermatol. 7:309–311. 2008. View Article : Google Scholar : PubMed/NCBI