Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models

  • Authors:
    • Xuan Yin Chen
    • Hui Bing Ruan
    • Xin Hua Long
    • Ai Fen Peng
    • Long Dian Zhou
    • Jia Ming Liu
    • Yang Zhou
    • Zhi Li Liu
  • View Affiliations

  • Published online on: March 29, 2017     https://doi.org/10.3892/etm.2017.4284
  • Pages: 2411-2416
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Abstract

Previous studies have demonstrated that fatty acid synthase (FASN) is overexpressed in osteosarcoma (OS) cells and tissues and, therefore, knockdown of FASN may inhibit OS cell proliferation, migration and invasion via regulation of the human epidermal growth factor receptor 2 (HER2)/phosphoinositide 3‑kinase (PI3K)/protein kinase B(Akt) signaling pathway in vitro. However, the tumor microenvironment has a crucial role in the determination of tumor malignant phenotype. The aim of the present study was to investigate the effect of knockdown of FASN on OS progression and the potential molecular mechanism in nude mice with orthotopic tumor implants in vivo. Results demonstrated that the knockdown of FASN markedly suppressed the growth and metastasis of OS, at least partially, by blocking the HER2/PI3K/Akt signal pathway in mice with intratibial 143B OS xenografts. These results suggest that the FASN/HER2/PI3K/Akt signaling pathway may be a potential therapeutic target for OS management.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen XY, Ruan HB, Long XH, Peng AF, Zhou LD, Liu JM, Zhou Y and Liu ZL: Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models. Exp Ther Med 13: 2411-2416, 2017
APA
Chen, X.Y., Ruan, H.B., Long, X.H., Peng, A.F., Zhou, L.D., Liu, J.M. ... Liu, Z.L. (2017). Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models. Experimental and Therapeutic Medicine, 13, 2411-2416. https://doi.org/10.3892/etm.2017.4284
MLA
Chen, X. Y., Ruan, H. B., Long, X. H., Peng, A. F., Zhou, L. D., Liu, J. M., Zhou, Y., Liu, Z. L."Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models". Experimental and Therapeutic Medicine 13.5 (2017): 2411-2416.
Chicago
Chen, X. Y., Ruan, H. B., Long, X. H., Peng, A. F., Zhou, L. D., Liu, J. M., Zhou, Y., Liu, Z. L."Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2411-2416. https://doi.org/10.3892/etm.2017.4284