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Article

Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models

  • Authors:
    • Xuan Yin Chen
    • Hui Bing Ruan
    • Xin Hua Long
    • Ai Fen Peng
    • Long Dian Zhou
    • Jia Ming Liu
    • Yang Zhou
    • Zhi Li Liu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, College of Humanities, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, P.R. China, Department of Orthopedics, Hong‑Du Traditional Chinese Medical Hospital, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 2411-2416
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    Published online on: March 29, 2017
       https://doi.org/10.3892/etm.2017.4284
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Abstract

Previous studies have demonstrated that fatty acid synthase (FASN) is overexpressed in osteosarcoma (OS) cells and tissues and, therefore, knockdown of FASN may inhibit OS cell proliferation, migration and invasion via regulation of the human epidermal growth factor receptor 2 (HER2)/phosphoinositide 3‑kinase (PI3K)/protein kinase B(Akt) signaling pathway in vitro. However, the tumor microenvironment has a crucial role in the determination of tumor malignant phenotype. The aim of the present study was to investigate the effect of knockdown of FASN on OS progression and the potential molecular mechanism in nude mice with orthotopic tumor implants in vivo. Results demonstrated that the knockdown of FASN markedly suppressed the growth and metastasis of OS, at least partially, by blocking the HER2/PI3K/Akt signal pathway in mice with intratibial 143B OS xenografts. These results suggest that the FASN/HER2/PI3K/Akt signaling pathway may be a potential therapeutic target for OS management.
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1 

Salah S, Ahmad R, Sultan I, Yaser S and Shehadeh A: Osteosarcoma with metastasis at initial diagnosis: Current outcomes and prognostic factors in the context of a comprehensive cancer center. Mol Clin Oncol. 2:811–816. 2014.PubMed/NCBI

2 

Jawad MU, Cheung MC, Clarke J, Koniaris LG and Scully SP: Osteosarcoma: Improvement in survival limited to high-grade patients only. J Cancer Res Clin Oncol. 137:597–607. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Mialou V, Philip T, Kalifa C, Perol D, Gentet JC, Marec-Berard P, Pacquement H, Chastagner P, Defaschelles AS and Hartmann O: Metastatic osteosarcoma at diagnosis: Prognostic factors and long-term outcome-the French pediatric experience. Cancer. 104:1100–1109. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Hegyi M, Semsei AF, Jakab Z, Antal I, Kiss J, Szendroi M, Csoka M and Kovacs G: Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. Pediatr Blood Cancer. 57:415–422. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Hess D and Igal RA: Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells. Exp Biol Med (Maywood). 236:707–713. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Alo PL, Amini M, Piro F, Pizzuti L, Sebastiani V, Botti C, Murari R, Zotti G and Di Tondo U: Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma. Anticancer Res. 27:2523–2527. 2007.PubMed/NCBI

7 

Walter K, Hong SM, Nyhan S, Canto M, Fedarko N, Klein A, Griffith M, Omura N, Medghalchi S, Kuhajda F and Goggins M: Serum fatty acid synthase as a marker of pancreatic neoplasia. Cancer Epidemiol Biomarkers Prev. 18:2380–2385. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, Inazuka F, Grisanzio C, Palescandolo E, Shin E, et al: Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst. 101:519–532. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Silva SD, Cunha IW, Younes RN, Soares FA, Kowalski LP and Graner E: ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. Oral Dis. 16:774–780. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Saati GE and Archer MC: Inhibition of Fatty Acid synthase and sp1 expression 3-3′-diindolylmethane in human breast cancer cells. Nutr Cancer. 63:790–794. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Notarnicola M, Pisanti S, Tutino V, Bocale D, Rotelli MT, Gentile A, Memeo V, Bifulco M, Perri E and Caruso MG: Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Genes Nutr. 6:63–69. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Notarnicola M, Messa C, Refolo MG, Tutino V, Miccolis A and Caruso MG: Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line. Lipids Health Dis. 10:102011. View Article : Google Scholar : PubMed/NCBI

13 

Zecchin KG, Rossato FA, Raposo HF, Melo DR, Alberici LC, Oliverira HC, Castilho RF, Coletta RD, Vercesi AE and Graner E: Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis. Lab Invest. 91:232–240. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Murata S, Yanagisawa K, Fukunaga K, Oda T, Kobayashi A, Sasaki R and Ohkohchi N: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. Cancer Sci. 101:1861–1865. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Liu ZL, Wang G, Peng AF, Luo QF, Zhou Y and Huang SH: Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis. Oncol Lett. 4:878–882. 2012.PubMed/NCBI

16 

Wang TF, Wang H, Peng AF, Luo QF, Liu ZL, Zhou RP, Gao S, Zhou Y and Chen WZ: Inhibition of fatty acid synthase suppresses U-2 OS cell invasion and migration via downregulating the activity of HER2/PI3K/AKT signaling pathway in vitro. Biochem Biophys Res Commun. 440:229–234. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Luetke A, Meyers PA, Lewis I and Juergens H: Osteosarcoma treatment - Where do we stand? A state of the art review. Cancer Treat Rev. 40:523–532. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Wang R, Zheng J, Zhang DS, Yang YH and Zhao ZF: Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation. Genet Mol Res. 14:7315–7325. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, et al: NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 34:5069–5079. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Gupte A, Baker EK, Wan SS, Stewart E, Loh A, Shelat AA, Gould CM, Chalk AM, Taylor S, Lackovic K, et al: Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a conserved therapeutic vulnerability in osteosarcoma. Clin Cancer Res. 21:3216–3229. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Tao J, Jiang MM, Jiang L, Salvo JS, Zeng HC, Dawson B, Bertin TK, Rao PH, Chen R, Donehower LA, et al: Notch activation as a driver of osteogenic sarcoma. Cancer Cell. 26:390–401. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Uemoto Y, Abe T, Tameoka N, Hasebe H, Inoue K, Nakajima H, Shoji N, Kobayashi M and Kobayashi E: Whole-genome association study for fatty acid composition of oleic acid in Japanese Black cattle. Anim Genet. 42:141–148. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Kuhajda FP: Fatty acid synthase and cancer: New application of an old pathway. Cancer Res. 66:5977–5980. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Zaytseva YY, Harris JW, Mitov MI, Kim JT, Butterfield DA, Lee EY, Weiss HL, Gao T and Evers BM: Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration. Oncotarget. 6:18891–19904. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Bauerschlag DO, Maass N, Leonhardt P, Verburg FA, Pecks U, Zeppernick F, Morgenroth A, Mottaghy FM, Tolba R, Meinhold-Heerlein I and Bräutigam K: Fatty acid synthase overexpression: Target for therapy and reversal of chemoresistance in ovarian cancer. J Transl Med. 13:1462015. View Article : Google Scholar : PubMed/NCBI

27 

Hamada S, Horiguchi A, Kuroda K, Ito K, Asano T, Miyai K and Iwaya K: Elevated fatty acid synthase expression in prostate needle biopsy cores predicts upgraded Gleason score in radical prostatectomy specimens. Prostate. 74:90–96. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Porta R, Blancafort A, Casòliva G, Casas M, Dorca J, Buxo M, Viñas G, Oliveras G and Puig T: Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients. Menopause. 21:188–191. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Agostini M, Almeida LY, Bastos DC, Ortega RM, Moreira FS, Seguin F, Zecchin KG, Raposo HF, Oliveira HC, Amoêdo ND, et al: The fatty acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongueoral squamous cell carcinomas. Mol Cancer Ther. 13:585–595. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Seguin F, Carvalho MA, Bastos DC, Agostini M, Zecchin KG, Alvarez-Flores MP, Chudzinski-Tavassi AM, Coletta RD and Graner E: The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas. Br J Cancer. 107:977–987. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Liu ZL, Mao JH, Peng AF, Yin QS, Zhou Y, Long XH and Huang SH: Inhibition of fatty acid synthase suppresses osteosarcoma cell invasion and migration via downregulation of the PI3K/Akt signaling pathway in vitro. Mol Med Rep. 7:608–612. 2013.PubMed/NCBI

32 

Liu ZL, Zhou Y, Luo QF, Hu M, Wang G, Huang SH and Shu Y: Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration. Indian J Pathol Microbiol. 55:163–169. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Dong Y, Liang G, Yuan B, Yang C, Gao R and Zhou X: MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway. Tumour Biol. 36:1477–1486. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Tomek K, Wagner R, Varga F, Singer CF, Karlic H and Grunt TW: Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer. Mol Cancer Res. 9:1767–1779. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Puig T, Turrado C, Benhamú B, Aguilar H, Relat J, Ortega-Gutiérrez S, Casals G, Marrero PF, Urruticoechea A, Haro D, et al: Novel inhibitors of fatty acid synthase with anticancer activity. Clin Cancer Res. 15:7608–7615. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Jiang B, Li EH, Lu YY, Jiang Q, Cui D, Jing YF and Xia SJ: Inhibition of fatty-acid synthase suppresses P-AKT and induces apoptosis in bladder cancer. Urology. 80:484. e9–15. 2012. View Article : Google Scholar

37 

Li N, Lu H, Chen C, Bu X and Huang P: Loss of fatty acid synthase inhibits the ‘HER2-PI3K/Akt axis’ activity and malignant phenotype of Caco-2 cells. Lipids Health Dis. 12:832013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen XY, Ruan HB, Long XH, Peng AF, Zhou LD, Liu JM, Zhou Y and Liu ZL: Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models. Exp Ther Med 13: 2411-2416, 2017.
APA
Chen, X.Y., Ruan, H.B., Long, X.H., Peng, A.F., Zhou, L.D., Liu, J.M. ... Liu, Z.L. (2017). Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models. Experimental and Therapeutic Medicine, 13, 2411-2416. https://doi.org/10.3892/etm.2017.4284
MLA
Chen, X. Y., Ruan, H. B., Long, X. H., Peng, A. F., Zhou, L. D., Liu, J. M., Zhou, Y., Liu, Z. L."Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models". Experimental and Therapeutic Medicine 13.5 (2017): 2411-2416.
Chicago
Chen, X. Y., Ruan, H. B., Long, X. H., Peng, A. F., Zhou, L. D., Liu, J. M., Zhou, Y., Liu, Z. L."Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2411-2416. https://doi.org/10.3892/etm.2017.4284
Copy and paste a formatted citation
x
Spandidos Publications style
Chen XY, Ruan HB, Long XH, Peng AF, Zhou LD, Liu JM, Zhou Y and Liu ZL: Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models. Exp Ther Med 13: 2411-2416, 2017.
APA
Chen, X.Y., Ruan, H.B., Long, X.H., Peng, A.F., Zhou, L.D., Liu, J.M. ... Liu, Z.L. (2017). Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models. Experimental and Therapeutic Medicine, 13, 2411-2416. https://doi.org/10.3892/etm.2017.4284
MLA
Chen, X. Y., Ruan, H. B., Long, X. H., Peng, A. F., Zhou, L. D., Liu, J. M., Zhou, Y., Liu, Z. L."Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models". Experimental and Therapeutic Medicine 13.5 (2017): 2411-2416.
Chicago
Chen, X. Y., Ruan, H. B., Long, X. H., Peng, A. F., Zhou, L. D., Liu, J. M., Zhou, Y., Liu, Z. L."Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3‑kinase/protein kinase B signaling pathway in xenograft models". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2411-2416. https://doi.org/10.3892/etm.2017.4284
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