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Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients

  • Authors:
    • Yuqiang Sun
    • Xiaofeng Wang
    • Ningwei Che
    • Huamin Qin
    • Shuping Liu
    • Xinling Wu
    • Minghai Wei
    • Huakun Cheng
    • Jian Yin
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Neurosurgery, Weinan Central Hospital, Weinan, Shaanxi 714000, P.R. China, Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Psychology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Neurosurgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150036, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2225-2234
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    Published online on: April 6, 2017
       https://doi.org/10.3892/etm.2017.4315
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Abstract

The aim of the present study was to investigate the effects of surgical intervention of focal cortical dysplasia (FCD) IIa on the outcome of epilepsy, and to evaluate the prognostic factors of seizure freedom. Patient data from epilepsy surgeries were retrospectively reviewed at the Second Affiliated Hospital of Dalian Medical University between 2007 and 2015. A total of 110 patients with a definite pathological diagnosis of FCD IIa were included. Moreover, the clinical characteristics, seizure outcome and quality of life in adults with FCD IIa were evaluated. The Engel seizure outcome achievements were class I in 72, class II in 20, class III in 11 and class IV in 7 patients. In addition, the Engel seizure outcome was relevant with the resection range of the lesions (P=0.028). The assessments of electrocorticography (ECoG) patterns and magnetic resonance imaging (MRI) are relevant to determining the extent of the resection, which may influence the surgery outcome (P=0.001 and P=0.023). Using multivariate regression analyses, the extent of resection, seizure frequency, preoperative ECoG and location of resection were the most important risk factors for seizure recurrence. The results of quality of life in epilepsy‑10 scoring revealed that the quality of life improved significantly following surgery (P<0.01). Moreover, surgical intervention, EcoG, MRI positioning and complete resection helped to have improved seizure control, relief of anxiety and quality of life. All these observations strongly recommend an early consideration of epilepsy surgery in FCD IIa patients.
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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Wang X, Che N, Qin H, Liu S, Wu X, Wei M, Cheng H and Yin J: Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients. Exp Ther Med 13: 2225-2234, 2017.
APA
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X. ... Yin, J. (2017). Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients. Experimental and Therapeutic Medicine, 13, 2225-2234. https://doi.org/10.3892/etm.2017.4315
MLA
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X., Wei, M., Cheng, H., Yin, J."Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients". Experimental and Therapeutic Medicine 13.5 (2017): 2225-2234.
Chicago
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X., Wei, M., Cheng, H., Yin, J."Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2225-2234. https://doi.org/10.3892/etm.2017.4315
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Wang X, Che N, Qin H, Liu S, Wu X, Wei M, Cheng H and Yin J: Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients. Exp Ther Med 13: 2225-2234, 2017.
APA
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X. ... Yin, J. (2017). Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients. Experimental and Therapeutic Medicine, 13, 2225-2234. https://doi.org/10.3892/etm.2017.4315
MLA
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X., Wei, M., Cheng, H., Yin, J."Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients". Experimental and Therapeutic Medicine 13.5 (2017): 2225-2234.
Chicago
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X., Wei, M., Cheng, H., Yin, J."Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2225-2234. https://doi.org/10.3892/etm.2017.4315
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