Open Access

Effects of polyvinylpyrrolidone-iodine on tendon-bone healing in a rabbit extra-articular model

  • Authors:
    • Peng Zhang
    • Yunlong Zhi
    • Hongwei Fang
    • Ziying Wu
    • Tianwu Chen
    • Jia Jiang
    • Shiyi Chen
  • View Affiliations

  • Published online on: April 19, 2017     https://doi.org/10.3892/etm.2017.4359
  • Pages: 2751-2756
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Polyvinylpyrrolidone-iodine (PVP-I) is a broad-spectrum antimicrobial agent, but its effects on tendon‑bone healing are unclear. The purpose of this study was to investigate the effects of PVP‑I on bone marrow mesenchymal stem cells (BMSCs) in vitro and on tendon‑bone healing in vivo. In this study, following investigation of the concentration‑dependent effects of PVP‑I on the viability and osteogenic differentiation of BMSCs, the appropriate concentration of PVP‑I was selected for animal experiments. New Zealand white rabbits received autologous tendon transplantation with and without PVP‑I treatment of the graft tendon. Subsequently, histological examination, biomechanical testing and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analyses were conducted. At 6 weeks post‑surgery, connective tissue and osteogenesis was observed at the tendon‑bone interface in the PVP-I group. At 12 weeks post‑surgery, the interface width in the PVP‑I group was much narrower compared with that of the control group. Furthermore, the biomechanical properties of the PVP‑I group were significantly stronger than those in the control group (P<0.05). RT‑qPCR examination revealed that the mRNA levels of bone morphogenetic protein‑2 and osteopontin in the PVP‑I group were higher than those in the control group at 6 weeks (P<0.05). In conclusion, these results indicated that PVP‑I promoted tendon‑bone healing via osteogenesis.

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June-2017
Volume 13 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang P, Zhi Y, Fang H, Wu Z, Chen T, Jiang J and Chen S: Effects of polyvinylpyrrolidone-iodine on tendon-bone healing in a rabbit extra-articular model. Exp Ther Med 13: 2751-2756, 2017
APA
Zhang, P., Zhi, Y., Fang, H., Wu, Z., Chen, T., Jiang, J., & Chen, S. (2017). Effects of polyvinylpyrrolidone-iodine on tendon-bone healing in a rabbit extra-articular model. Experimental and Therapeutic Medicine, 13, 2751-2756. https://doi.org/10.3892/etm.2017.4359
MLA
Zhang, P., Zhi, Y., Fang, H., Wu, Z., Chen, T., Jiang, J., Chen, S."Effects of polyvinylpyrrolidone-iodine on tendon-bone healing in a rabbit extra-articular model". Experimental and Therapeutic Medicine 13.6 (2017): 2751-2756.
Chicago
Zhang, P., Zhi, Y., Fang, H., Wu, Z., Chen, T., Jiang, J., Chen, S."Effects of polyvinylpyrrolidone-iodine on tendon-bone healing in a rabbit extra-articular model". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2751-2756. https://doi.org/10.3892/etm.2017.4359