Experimental and Therapeutic Medicine Special Issues

Autistic Spectrum Disorder - from puzzling to manageable

Lead Editor:

    Dr Felician Stancioiu
    Fundatia Bio-Forum

Much information was accumulated in the past decades about the autistic spectrum disorder (ASD) and yet this has not given us a good understanding of this multi-faceted pathology, which can be compared to "mother nature" mixing together the overlapping pieces from a few different puzzles and expecting us to solve the one which correctly applies to each patient. Pharmacological interventions (oxytocin, antipsychotics and stimulants) and intensive psychotherapy have yielded good results, and recently cellular therapies with mesenchymal and hematopoietic stem cells yielded excellent progress in some children. However, we are faced with a seemingly increasing incidence (about 1 in 50-100 births which may be increased by the pandemic), and we are proposing a collaborative approach for trying to identify the pieces of the puzzles and help put it back together in working order.

Submission deadline: 17 July 2023

Digestive-cutaneous molecular interrelations in the pathogenesis of inflammatory disorders.

Lead Editor:

    Dr Raluca Simona Costache
    Carol Davila University Of Medicine and Pharmacy

Both digestive and skin disorders appear to share some pathogenic molecular pathways that clarify intricate relations and therapeutic opportunities. Even more, the relatively new concerns on the microbiota colonizing both skin and intestinal mucous surfaces and its relationship with various pathologic states seem to represent a promising research field for the next years.

Submission deadline: 06 July 2023

Novel Approaches to Diagnosis and Treatment of Sino-nasal Pathology

Lead Editor:

    Professor Horia Mocanu
    Titu Maiorescu University

The nose and paranasal sinuses as part of the respiratory system, represent a first contact point for various harmful factors and are, therefore, the site for an array of pathologies that include, amongst others, inflammation, allergies, trauma and tumors. In recent years, the diagnostic and therapeutic methods for nasal and sinus pathologies, such as Chronic Rhinosinusitis (CRS) and Allergic Rhinitis have developed consistently but many parameters still remain unknown regarding medical treatments, formulations, doses, treatment duration. Also, the patient’s lack of compliance to classical treatment can sometimes prompt the physician to experimenting with nonconventional treatment and techniques. The surgical approach to sinusitis is even more complicated as the results are inconsistent and the techniques develop constantly. Tumoral and traumatic pathology of the nose and sinuses are also key points that raise a number of questions regarding techniques, guidelines and results. In this special issue, we propose submission of full original communications, both original research and review articles, related to the above-mentioned topics. We especially encourage the presentation of novel and original treatments and techniques including immunologic, homeopathic and alternative treatments as well as novel diagnostic techniques and protocols expanding to real world practice.

Submission deadline: 06 July 2023

Digestive and cutaneous inflammatory disorders - molecular pathogenic bridges and therapies

Lead Editor:

    Dr Daniel Costache
    Carol Davila University Central Emergency Military Hospital

Recent years allows us to realize that there are so many interdisciplinarities among various specialties. If dermatological and rheumatological disorders are more and more closely related, it appears that also dermatological and gastroenterological diseases span over mutual molecular mechanisms, which proposes a unitary therapeutic approach.

Submission deadline: 04 July 2023

New strategy and technology following surgical resection.

Lead Editor:

    Mr Norikatsu Miyoshi
    Osaka University

In recent years, the new strategy and technology are reported very effective, such as liquid biopsy (cfDNA/ctDNA), NGS, artificial intelligence, and minimally invasive surgery (robotic/laparoscopic surgery, and regenerative medicine, in order to improve the patients' QOL after radical surgery. Here, we introduce and discuss these new strategy and technology supposed after surgical resection, and the future.

Submission deadline: 04 July 2023


Lead Editor:

    Dr Rui-Qun Qi
    The First Hospital of China Medical University

There are more than 2000 kinds of skin diseases. Immune factors affect the occurrence and development of many diseases. In recent years, immunization related biological agents, represented by monoclonal antibodies, have achieved amazing results in clinical treatment. Physical treatments such as light and hyperthermia have been found to clearly induce anti infection immunity, which has the potential to replace previous trauma treatment, bring better non-invasive treatment experience to patients, and significantly reduce the recurrence rate. Basic and clinical immunology related to immune dermatosis has become a research hotspot, and will have a more far-reaching impact on diagnosis and treatment in the future.

Submission deadline: 01 June 2023

Experimental target biomarkers for oral diseases diagnosis and treatment

Lead Editor:

    Professor Gaetano Isola
    University of Catania

Nowadays, with the development of new and highly sensitive, blood is not the only medium of choice for the diagnosis of several diseases and pathological conditions. Saliva and related oral biomarkers are now considered a safe and non-invasive sample to study oral and systemic diseases, showing great diagnostic potential. According to several recent studies, saliva has emerged as an emerging biofluid for the early diagnosis of several diseases, indicated as a mirror of oral and systemic health and a valuable source of clinically relevant information. Indeed, several studies have observed that saliva is useful for detecting and diagnosing malignant tumours, human immunodeficiency virus, heart disease, and autoimmune diseases. The growing realisation that saliva is an inexhaustible source of information has led to the coining of the term ‘Salivaomics’, which includes five “omics” in connection with the main constituents of saliva: genome and epigenome, transcriptomics, metabolomics, lipidomics, proteomics and microbiota. All those may be changed by disease state, so they offer significant advantages in the early diagnosis and prognosis of oral diseases. The aim of the present special issue is to update and highlight the new frontiers of salivaomics and related oral biomarkers in diagnosing and managing oral disorders, such as periodontitis, premalignant disorders, and oral squamous cell carcinoma (OSCC).

Submission deadline: 01 June 2023

Preeclampsia and Eclampsia, Biochemical mechanisms of Pathophysiology. Prediction,diagnosis and management.

Lead Editor:

    Dr Panagiotis Peitsidis
    Rea Maternity Hospital

Dear Colleagues, Preeclampsia and Eclampsia are serious hypertensive disorders of pregnancy.These clinical entities are diagnosed after 20 weeks of gestation and may affect many organs such as , liver,kidneys,brain etc. The mechanisms that trigger these conditions are not fully understood however the role of placenta is crucial and several mechanisms of development of hypertensive disease have been proposed. Prediction,diagnosis and management is a difficult task that may require a multidisciplinary clinical approach by several specialties. In this issue we welcome Narrative reviews,Systematic reviews, Mini-reviews,Observational,Experimental studies regarding Preeclampsia and Eclampsia. Emphasis is given in mechanisms of development biochemical,molecular,genetic; in the prediction,diagnosis and management. Furthermore the cardinal topic of future directions should be discussed.

Submission deadline: 01 June 2023

Air Pollution Exposure and Respiratory Diseases

Lead Editor:

    Professor Elizabeth C Matsui
    the University of Texas at Austin
    United States

The respiratory system, as the first point of contact with inhaled pollutants, is uniquely vulnerable and eventually reveals signs and symptoms if abnormal. Around 90% of the population worldwide breathes in the air with pollution, consisting of harmful or poisonous substances in outdoor or indoor air. The indoor air quality may be even more important than outdoor quality because of exposure time to pollution. Air pollution is the cause and aggravating factor of many respiratory diseases like chronic obstructive pulmonary disease (COPD), asthma, and lung cancer. In general, children and the elderly are considered more susceptible to air pollution effects than other groups. PM2.5 particulates and metallic elements are also known to contribute to health diseases. Both short-term and long-term exposure to air pollutants were associated with respiratory diseases. Individual exposures depend on many time- and location-specific impact factors, including pollutant type, pollutant concentration in the air, indoor sources, and second-hand smoke. In addition, many studies have shown that people can reduce their susceptibility to pollution through air filters, face masks, medical or chemoprevention methods. Recently, most multi-omics studies have focused on the relationship between environmental exposures and human health, assessing and measuring advances in DNA methylation, microRNA expression and proceeding in epigenetic regulation, protein expression, and metabolic effects. However, the results are still not fully established. Therefore, this special issue encourages potential authors to identify novel environmental risk factors, provide more evidence on the effects of harmful environmental exposures on respiratory diseases, and explore the underlying mechanisms between them, by collecting large samples of longitudinal cohorts, national-representative data, or well-conducting clinical trials. Laboratory, epidemiological and modeling studies on the effects of environmental exposure on respiratory diseases are also welcome. We aim to provide more evidence on the causal relationships between air pollution exposures and respiratory diseases.

Submission deadline: 11 May 2023

The future of microbiota in human diseases: from diagnosis to treatments

Lead Editor:

    Professor Amedeo Amedei
    University of Florence

The microbiota, the trillions of microorganisms that live on and in humans, as well as the roles they may play in nutrition, sickness, cancer, and even brain development, have sparked a surge of interest in the last decade. Many scientists want to learn more about the microbiota so that we can use it to well define the pathogenesis of more human diseases and to improve the health. But different questions are currently open: how do we get there, and what challenges will we face along the way? What does microbial research have in store for the future? What is the future of microbiome research? What has to be done in order for this field to fulfil its potential? The idea of this special issue is to explore the innovative studies regarding the impacting role of microbiota in several human diseases and also its therapeutic approaches

Submission deadline: 16 August 2023

Journal Cover

Volume 25 Issue 4

Print ISSN: 1792-0981
Online ISSN: 1792-1015

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