Experimental and Therapeutic Medicine Special Issues

Dermato-endocrinology: from cutaneous findings in endocrine diseases to skin conditions correlated with hormonal anomalies

Lead Editor:

    Dr Florica Sandru
    Carol Davila University of Medicine and Pharmacy Bucharest

Dermato-endocrinology represents a bi-disciplinary approach that introduces a large area of medical issues requiring both endocrinologists and dermatologists. This Special Issue addresses various topics such as: estrogen receptors in melanoma, cutaneous manifestations of endocrine tumors and neuroendocrine neoplasia underlying various hormonal and genetic conditions, including familial syndromes. Also, thyroid pathology had been associated with different skin and hair follicle disorders such as vitiligo, lichen or alopecia. Insulin resistance as found in diabetes mellitus, acromegaly, androgen producing ovarian tumors and polycystic ovary syndrome may associate several dermatological signatures in terms of acanthosis nigricans. Hyperpigmentation may be a major clue in primary ovarian insufficiency or a cancer- related Cushing syndrome.

Submission deadline: 26 October 2024

Exploring Pediatric Frontiers: From Rare Diseases to Comprehensive Cases

Lead Editor:

    Professor George Imataka
    Dokkyo Medical University

Dear Esteemed Experts in Pediatric Medicine, We are excited to announce an upcoming comprehensive special issue in our journal, Experimental and Therapeutic Medicine, focusing on the field of pediatrics. As part of this special issue, we are eager to provide an opportunity for you to share your expertise and research findings. We also accept rare case report related to all pediatric fields. This special issue will encompass a wide range of topics within pediatric medicine, spanning from neonatology to adolescent medicine. We believe this special issue will reflect the latest research, innovations, and insights in the field of pediatric medicine. While we encourage contributions related to the following topics, we welcome submissions on any theme within the broader scope of pediatric medicine: - Diagnosis and treatment of rare diseases in children - Pediatric growth and development - Pediatric infectious diseases and immunology - Pediatric neurology and behavioral science - Pediatric nutrition and health - Pediatric epidemiology and preventive medicine - Other review and case report.

Submission deadline: 03 October 2024

Traumatic Brain Injury

Lead Editor:

    Dr Theodosis Kalamatianos
    National and Kapodistrian University of Athens

Dear Colleagues, I am pleased to invite you to contribute to the forthcoming special issue of Experimental and Therapeutic Medicine dedicated to the critical exploration of Traumatic Brain Injury (TBI). TBI remains a substantial global health problem. Understanding the intricate pathophysiological aspects of TBI through basic and clinical research is pivotal for advancing the field and ultimately providing new diagnostic/prognostic and therapeutic avenues for improving patient management and outcomes. Advances in medical technologies for enhanced monitoring, imaging and nervous system interfacing combined with improved rehabilitation strategies are also likely to significantly contribute towards this goal. This special issue aims at providing a comprehensive platform for the dissemination of cutting-edge research and insights in this critical domain. Topics of interest, on all age groups from the pediatric to the geriatric patient, include, but are not limited to: experimental (animal) models, genetic factors, drug or non-drug (e.g transcranial stimulation) therapy, surgical approaches/interventions, rehabilitation approaches, neuroimaging, neuromonitoring, biomarkers and the use artificial intelligence tools. Original research articles and comprehensive reviews that provide valuable insights into the aforementioned topics will be considered. This special issue aims at bridging the gap between research and clinical practice, fostering collaboration and promoting advancements in the field of TBI.

Submission deadline: 28 September 2024

Novel signaling pathway and therapy in gastrointestinal neoplasms

Lead Editor:

    Dr Eriko Katsuta
    Department of Oncology, Yokohama City University Graduate School of Medicine

We have made tremendous progress in early detection, prevention, and treatment of gastrointestinal (GI) cancer in the past few decades. The advance in technology of GI endoscopy has contributed to the early detection of GI cancer. Eradicating Helicobacter pylori by antibiotics has reduced gastric cancer prevalence. Development of molecular targeting agents and immune checkpoint inhibitors have provided new treatment strategies and improved patient prognosis in GI malignancy. Nevertheless, GI malignancies still account for more than 25% of all cancer incidence and 35% of cancer related death in worldwide. Therefore, investigating molecular mechanisms of tumor development, progression, resistance and metastasis is crucial. In addition, clinical studies of GI cancer detection, prevention and treatment would bring new insight into GI cancers in order to improve GI cancer patient prognosis. In this special issue, we aim to elucidate the molecular mechanisms underlying cancer development, progression, metastasis, and drug resistance in GI cancer. Furthermore, we will also focus on clinical studies of novel prevention, detection, and treatment proposals and innovative approaches to develop novel strategies to manage GI malignancies.

Submission deadline: 27 September 2024

The role of biofactors in the diagnosis, treatment, and rehabilitation of cardiovascular disease

Lead Editor:

    Dr Wen-Jun Tu
    Chinese Academy of Medical Sciences & Peking Union Medical CollegeThis link is disabled.,

ardiovascular diseases (CVDs) encompass a range of heart and blood vessel disorders, including coronary heart disease, cerebrovascular disease, and peripheral arterial disease. Remarkable progress has been made in the diagnosis, prevention, treatment, and care of CVD in recent years. However, CVDs remain the primary cause of global mortality and disability. Notably, comorbidities involving the heart in neurological diseases and the brain in cardiovascular diseases are prevalent, yet interactions within the brain-heart axis on disease development and progression remains poorly understood. Several CVDs share common risk factors, and a deeper comprehension of these conditions will provide valuable insights for future treatment and personalized healthcare. Biomarkers present a dynamic and robust approach to comprehending the spectrum of CVD. They find utility in observational and analytic epidemiology, randomized clinical trials, screening, diagnosis, and prognosis. Biomarkers have the potential to reflect the entire continuum of disease, ranging from its earliest manifestations to terminal stages. Nevertheless, meticulous evaluation of biomarker validity is necessary, taking into account the stage of the disease. Variability in biomarker measurements can stem from individual factors as well as laboratory procedures. The role of biomarkers has been proposed in the context of the aging brain, stroke, and cardiac failure, which are two prevalent and debilitating vascular pathologies. This Special Issue aims to explore the significance of biomarkers in CVD, shedding light on the physiological and pathogenic mechanisms underlying these conditions. Additionally, we will discuss treatment, rehabilitation, and prevention options utilizing biomarkers for CVD and associated risk factors. Special attention will be given to biomarkers and cardiac dysfunction in the context of stroke. For this research topic, we invite original research articles and comprehensive reviews centered around the following themes: • Diagnostic and prognostic markers in stroke and coronary heart disease • Predictive, diagnostic, and prognostic markers for atherosclerosis • Epidemiological characteristics and risk factors of Cardiovascular diseases • The physiological and pathogenesis role of biomarkers in Cardiovascular diseases • Main prevention, diagnosis, and treatment strategies for biomarkers in Cardiovascular diseases • From basic to clinical application- Clinical translational research of Cardiovascular diseases • The effectiveness and feasibility of Cardiovascular disease treatment • Cardiac dysfunction and oxidative stress and inflammation markers in the setting of stroke

Submission deadline: 19 September 2024

The current state of the art in biliary tract cancer screening, diagnosis, and treatment

Lead Editor:

    Gastroenterology Unit, National Institute of Gastroenterology - IRCCS “Saverio de Bellis”

There has been considerable advancement in recent years in the research of biliary tract cancer screening, early diagnosis, and early therapy. Researchers have been working to create more effective screening strategies that can detect the early stages of the disease when it is still treatable. In addition, advances in imaging technology and biomarker testing have made it possible to diagnose the disease earlier, which can improve the chances of successful treatment. Treatment options have also enhanced, with new treatments and surgical techniques that can help to lengthen survival and improve quality of life for patients with biliary tract cancer. Despite these advancements, more research is still required to further improve screening, diagnosis, and treatment for this challenging disease.

Submission deadline: 19 September 2024

Autistic Spectrum Disorder - from puzzling to manageable

Lead Editor:

    Dr Felician Stancioiu
    Fundatia Bio-Forum

Much information was accumulated in the past decades about the autistic spectrum disorder (ASD) and yet this has not given us a good understanding of this multi-faceted pathology, which can be compared to "mother nature" mixing together the overlapping pieces from a few different puzzles and expecting us to solve the one which correctly applies to each patient. Pharmacological interventions (oxytocin, antipsychotics and stimulants) and intensive psychotherapy have yielded good results, and recently cellular therapies with mesenchymal and hematopoietic stem cells yielded excellent progress in some children. However, we are faced with a seemingly increasing incidence (about 1 in 50-100 births which may be increased by the pandemic), and we are proposing a collaborative approach for trying to identify the pieces of the puzzles and help put it back together in working order.

Submission deadline: 17 July 2024

Digestive-cutaneous molecular interrelations in the pathogenesis of inflammatory disorders.

Lead Editor:

    Dr Raluca Simona Costache
    Carol Davila University Of Medicine and Pharmacy

Both digestive and skin disorders appear to share some pathogenic molecular pathways that clarify intricate relations and therapeutic opportunities. Even more, the relatively new concerns on the microbiota colonizing both skin and intestinal mucous surfaces and its relationship with various pathologic states seem to represent a promising research field for the next years.

Submission deadline: 06 July 2024

Novel Approaches to Diagnosis and Treatment of Sino-nasal Pathology

Lead Editor:

    Professor Horia Mocanu
    Titu Maiorescu University

The nose and paranasal sinuses as part of the respiratory system, represent a first contact point for various harmful factors and are, therefore, the site for an array of pathologies that include, amongst others, inflammation, allergies, trauma and tumors. In recent years, the diagnostic and therapeutic methods for nasal and sinus pathologies, such as Chronic Rhinosinusitis (CRS) and Allergic Rhinitis have developed consistently but many parameters still remain unknown regarding medical treatments, formulations, doses, treatment duration. Also, the patient’s lack of compliance to classical treatment can sometimes prompt the physician to experimenting with nonconventional treatment and techniques. The surgical approach to sinusitis is even more complicated as the results are inconsistent and the techniques develop constantly. Tumoral and traumatic pathology of the nose and sinuses are also key points that raise a number of questions regarding techniques, guidelines and results. In this special issue, we propose submission of full original communications, both original research and review articles, related to the above-mentioned topics. We especially encourage the presentation of novel and original treatments and techniques including immunologic, homeopathic and alternative treatments as well as novel diagnostic techniques and protocols expanding to real world practice.

Submission deadline: 06 July 2024

Digestive and cutaneous inflammatory disorders - molecular pathogenic bridges and therapies

Lead Editor:

    Dr Daniel Costache
    Carol Davila University Central Emergency Military Hospital

Recent years allows us to realize that there are so many interdisciplinarities among various specialties. If dermatological and rheumatological disorders are more and more closely related, it appears that also dermatological and gastroenterological diseases span over mutual molecular mechanisms, which proposes a unitary therapeutic approach.

Submission deadline: 04 July 2024

Journal Cover

Volume 27 Issue 5

Print ISSN: 1792-0981
Online ISSN: 1792-1015

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