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Article

Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

  • Authors:
    • Lian Liu
    • Junqiang Yang
    • Feng Qian
    • Chengbiao Lu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Medical School of Yangtze University, Jingzhou, Hubei 434023, P.R. China, Laboratory of Neuronal and Brain Disease Modulation, Yangtze University, Jingzhou, Hubei 434023, P.R. China
  • Pages: 439-446
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    Published online on: May 23, 2017
       https://doi.org/10.3892/etm.2017.4498
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Abstract

A high-fat diet (HFD) is highly correlated to obesity, metabolic diseases and certain behavioral changes. However, the effects of post‑weaning HFD in rats during puberty and the role of the hypothalamic-pituitary-adrenal (HPA) axis in this process have remained elusive. The present study hypothesized that the HPA axis mediates the behavioral alterations induced by a post‑weaning HFD. To investigate this, female rats were divided into two groups, one of which was fed a HFD from postnatal weeks (PWs) 4‑12, while the other group received standard chow. Rats in each group were then subdivided into two subgroups each, and from PW 9‑12, animals from one of the two subgroups were subjected to chronic mild stress (CMS), while the other subgroup received no stress. At PW 12, the body weight of rats receiving a HFD but no DMS was significantly higher than that in the control group. The frequency of crossing and rearing in the open field test and the time in the center of the Y‑maze were decreased following CMS. Total time to escape was decreased in rats receiving HFD and after CMS. The serum levels of adrenocorticotropic hormone and corticosterone were increased in rats receiving an HFD and after CMS, and the mRNA levels of corticotropin‑releasing hormone and arginine vasopressin in the hypothalamus were increased in the HFD + CMS group compared to that in the control group. The mRNA expression of glucocorticoid receptor (GR) in the hippocampi of rats in the HFD + CMS group was significantly decreased and the mineralocorticoid receptor/GR ratio was increased compared to that in the groups receiving either CMS or a HFD. In conclusion, these results indicated that female rats fed a post‑weaning HFD showed HPA axis hypersensitivity under CMS, which may mediate behavioral alterations.
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Copy and paste a formatted citation
Spandidos Publications style
Liu L, Yang J, Qian F and Lu C: Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress. Exp Ther Med 14: 439-446, 2017.
APA
Liu, L., Yang, J., Qian, F., & Lu, C. (2017). Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress. Experimental and Therapeutic Medicine, 14, 439-446. https://doi.org/10.3892/etm.2017.4498
MLA
Liu, L., Yang, J., Qian, F., Lu, C."Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress". Experimental and Therapeutic Medicine 14.1 (2017): 439-446.
Chicago
Liu, L., Yang, J., Qian, F., Lu, C."Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress". Experimental and Therapeutic Medicine 14, no. 1 (2017): 439-446. https://doi.org/10.3892/etm.2017.4498
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Yang J, Qian F and Lu C: Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress. Exp Ther Med 14: 439-446, 2017.
APA
Liu, L., Yang, J., Qian, F., & Lu, C. (2017). Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress. Experimental and Therapeutic Medicine, 14, 439-446. https://doi.org/10.3892/etm.2017.4498
MLA
Liu, L., Yang, J., Qian, F., Lu, C."Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress". Experimental and Therapeutic Medicine 14.1 (2017): 439-446.
Chicago
Liu, L., Yang, J., Qian, F., Lu, C."Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress". Experimental and Therapeutic Medicine 14, no. 1 (2017): 439-446. https://doi.org/10.3892/etm.2017.4498
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