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Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription

  • Authors:
    • Canhua Zhang
    • Abulizi Abudula
    • Maliyegu Awuti
    • Huiwu Wang
    • Xiaimuxikamaier Aihemaiti
    • Turghun Tusung
    • Xierzhatijiang Sulaiman
    • Halmurat Upur
  • View Affiliations / Copyright

    Affiliations: School of Uyghur Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Key Laboratory of High‑Incident Diseases in Uyghur Ethnic Population Supported by The Chinese Ministry of Education, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Respiratory Pneumology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Pulmonary Function, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 267-275
    |
    Published online on: May 23, 2017
       https://doi.org/10.3892/etm.2017.4500
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Abstract

The therapeutic effect of Uighur prescription on abnormal Savda in asthma patients was evaluated using plasma proteomics in order to elucidate the biological mechanism and identify potential therapeutic targets of abnormal Savda. In the present study, 40 asthma patients with abnormal Savda including abnormal Savda Munziq and Savda Mushil were enrolled and treated with Uighur prescription. The effect of Uighur prescription on protein expression and potential targets was investigated by isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics and bioinformatics analysis. Expression of candidate proteins was verified by an enzyme‑linked immunosorbent assay. Following treatment with the Uighur prescription, 22 proteins were differentially expressed in the plasma of patients with asthma and abnormal Savda. The majority of these proteins were localized in intermediate filaments and the cytoskeleton and acted as antioxidant enzymes and binding proteins. Furthermore, they participated in the defense and inflammatory response, and the response to oxidative stress and wound healing. Peroxiredoxin 2 and carboxypeptidase B2 expression was significantly upregulated, whereas S100A7 was considerably downregulated in the whole plasma of patients (all P<0.05) in accordance with the iTRAQ proteomics data. Uighur prescription of abnormal Savda may affect the whole regulatory network of protein expression that is altered following the development of abnormal Savda in patients with asthma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Abudula A, Awuti M, Wang H, Aihemaiti X, Tusung T, Sulaiman X and Upur H: Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription. Exp Ther Med 14: 267-275, 2017.
APA
Zhang, C., Abudula, A., Awuti, M., Wang, H., Aihemaiti, X., Tusung, T. ... Upur, H. (2017). Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription. Experimental and Therapeutic Medicine, 14, 267-275. https://doi.org/10.3892/etm.2017.4500
MLA
Zhang, C., Abudula, A., Awuti, M., Wang, H., Aihemaiti, X., Tusung, T., Sulaiman, X., Upur, H."Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription". Experimental and Therapeutic Medicine 14.1 (2017): 267-275.
Chicago
Zhang, C., Abudula, A., Awuti, M., Wang, H., Aihemaiti, X., Tusung, T., Sulaiman, X., Upur, H."Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription". Experimental and Therapeutic Medicine 14, no. 1 (2017): 267-275. https://doi.org/10.3892/etm.2017.4500
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Abudula A, Awuti M, Wang H, Aihemaiti X, Tusung T, Sulaiman X and Upur H: Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription. Exp Ther Med 14: 267-275, 2017.
APA
Zhang, C., Abudula, A., Awuti, M., Wang, H., Aihemaiti, X., Tusung, T. ... Upur, H. (2017). Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription. Experimental and Therapeutic Medicine, 14, 267-275. https://doi.org/10.3892/etm.2017.4500
MLA
Zhang, C., Abudula, A., Awuti, M., Wang, H., Aihemaiti, X., Tusung, T., Sulaiman, X., Upur, H."Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription". Experimental and Therapeutic Medicine 14.1 (2017): 267-275.
Chicago
Zhang, C., Abudula, A., Awuti, M., Wang, H., Aihemaiti, X., Tusung, T., Sulaiman, X., Upur, H."Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription". Experimental and Therapeutic Medicine 14, no. 1 (2017): 267-275. https://doi.org/10.3892/etm.2017.4500
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