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Article Open Access

MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1

Retraction in: /10.3892/etm.2021.10628
  • Authors:
    • Quanqing Zou
    • Qianli Tang
    • Yinhua Pan
    • Xuedi Wang
    • Xiaofeng Dong
    • Zhongxiao Liang
    • Dong Huang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of General Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Hepatobiliary and Endocrine Surgery, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1009-1016
    |
    Published online on: June 13, 2017
       https://doi.org/10.3892/etm.2017.4590
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Abstract

MicroRNAs (miRs), which are a class of small non-coding RNAs, are key regulators of gene expression via induction of translational repression or mRNA degradation. However, the molecular mechanism of miR‑22 underlying the malignant progression of breast cancer, remains to be elucidated. The present study aimed to explore the regulatory mechanism of miR‑22 in breast cancer cell growth and metastasis. Reverse transcription‑quantitative polymerase chain reaction data revealed that miR‑22 was significantly downregulated in breast cancer tissues, compared with adjacent non‑tumor tissues. Furthermore, the miR‑22 levels were further decreased in stage III‑IV, compared with stage I‑II breast cancer. In addition, low miR‑22 levels were significantly associated with the poor differentiation, metastasis and advanced clinical stages of breast cancer. Sirtuin1 (SIRT1) was demonstrated to act as a direct target gene of miR‑22 and its protein expression negatively regulated by miR‑22 in the MCF‑7 breast cancer cell line. Furthermore, SIRT1 expression levels were significantly upregulated in breast cancer tissues, compared with adjacent non‑tumor tissues. SIRT1 levels were observed to be increased in stage III‑IV when compared with stage I‑II breast cancer. miR‑22 overexpression decreased the proliferation, migration and invasion of MCF‑7 cells, whereas overexpression of SIRT1 eliminated the suppressive effects of the miR‑22 overexpression on the malignant phenotype of MCF‑7 cells. The results of the present study therefore suggested that miR‑22 demonstrated suppressive effects on breast cancer growth and metastasis via targeting SIRT1, and thus the miR‑22/SIRT1 axis may be used as a novel and potential therapeutic target for breast cancer in the future.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Segovia-Mendoza M, González-González ME, Barrera D, Díaz L and García-Becerra R: Efficacy and mechanism of action of the tyrosine kinase inhibitors gefitinib, lapatinib and neratinib in the treatment of HER2-positive breast cancer: Preclinical and clinical evidence. Am J Cancer Res. 5:2531–2561. 2015.PubMed/NCBI

5 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Lin Y, Liu AY, Fan C, Zheng H, Li Y, Zhang C, Wu S, Yu D, Huang Z, Liu F, et al: MicroRNA-33b inhibits breast cancer metastasis by targeting HMGA2, SALL4 and Twist1. Sci Rep. 5:99952015. View Article : Google Scholar : PubMed/NCBI

8 

Xue J, Chen Z, Gu X, Zhang Y and Zhang W: MicroRNA-148a inhibits migration of breast cancer cells by targeting MMP-13. Tumour Biol. 37:1581–1590. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Yoo JO, Kwak SY, An HJ, Bae IH, Park MJ and Han YH: miR-181b-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG. Biochim Biophys Acta. 1863:1601–1611. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Yao Y, Hu J, Shen Z, Yao R, Liu S, Li Y, Cong H, Wang X, Qiu W and Yue L: MiR-200b expression in breast cancer: A prognostic marker and act on cell proliferation and apoptosis by targeting Sp1. J Cell Mol Med. 19:760–769. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Ye ZB, Ma G, Zhao YH, Xiao Y, Zhan Y, Jing C, Gao K, Liu ZH and Yu SJ: miR-429 inhibits migration and invasion of breast cancer cells in vitro. Int J Oncol. 46:531–538. 2015.PubMed/NCBI

12 

Wang W, Li F, Zhang Y, Tu Y, Yang Q and Gao X: Reduced expression of miR-22 in gastric cancer is related to clinicopathologic characteristics or patient prognosis. Diagn Pathol. 8:1022013. View Article : Google Scholar : PubMed/NCBI

13 

Ling B, Wang GX, Long G, Qiu JH and Hu ZL: Tumor suppressor miR-22 suppresses lung cancer cell progression through post-transcriptional regulation of ErbB3. J Cancer Res Clin Oncol. 138:1355–1361. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Jiang R, Deng L, Zhao L, Li X, Zhang F, Xia Y, Gao Y, Wang Xa and Sun B: miR-22 promotes HBV-related hepatocellular carcinoma development in males. Clin Cancer Res. 17:5593–5603. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Pandey DP and Picard D: miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA. Mol Cell Biol. 29:3783–3790. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Xiong J, Yu D, Wei N, Fu H, Cai T, Huang Y, Wu C, Zheng X, Du Q, Lin D and Liang Z: An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples. FEBS J. 277:1684–1694. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Chen B, Tang H, Liu X, Liu P, Yang L, Xie X, Ye F, Song C, Xie X and Wei W: miR-22 as a prognostic factor targets glucose transporter protein type 1 in breast cancer. Cancer Lett. 356:410–417. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Patel JB, Appaiah HN, Burnett RM, Bhat-Nakshatri P, Wang G, Mehta R, Badve S, Thomson MJ, Hammond S, Steeg P, et al: Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22. Oncogene. 30:1290–1301. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi RU, Takata T, Shimamoto A, et al: miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol. 193:409–424. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kong LM, Liao CG, Zhang Y, Xu J, Li Y, Huang W, Zhang Y, Bian H and Chen ZN: A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis. Cancer Res. 74:3764–3778. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Shao P, Liu Q, Maina PK, Cui J, Bair TB, Li T, Umesalma S, Zhang W and Qi HH: Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis. Nucleic Acids Res. Nov 29–2016.(Epub ahead of print).

22 

Koufaris C, Valbuena GN, Pomyen Y, Tredwell GD, Nevedomskaya E, Lau CH, Yang T, Benito A, Ellis JK and Keun HC: Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells. Oncogene. 35:2766–2776. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Damavandi Z, Torkashvand S, Vasei M, Soltani BM, Tavallaei M and Mowla SJ: Aberrant expression of breast development-related microRNAs, miR-22, miR-132 and miR-212, in breast tumor tissues. J Breast Cancer. 19:148–155. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Pandey AK, Zhang Y, Zhang S, Li Y, Tucker-Kellogg G, Yang H and Jha S: TIP60-miR-22 axis as a prognostic marker of breast cancer progression. Oncotarget. 6:41290–41306. 2015.PubMed/NCBI

25 

Lin L, Zheng X, Qiu C, Dongol S, Lv Q, Jiang J, Kong B and Wang C: SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. Oncol Rep. 32:2831–2835. 2014.PubMed/NCBI

26 

Li L and Bhatia R: Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells. Curr Opin Hematol. 22:324–329. 2015.PubMed/NCBI

27 

Qu Y, Zhang J, Wu S, Li B, Liu S and Cheng J: SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines. Neurosci Lett. 525:168–172. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Ohanna M, Bonet C, Bille K, Allegra M, Davidson I, Bahadoran P, Lacour JP, Ballotti R and Bertolotto C: SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells. Oncotarget. 5:2085–2095. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V and Thangaraju M: SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor a in breast cancer. Cancer Res. 71:6654–6664. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Cao YW, Li YC, Wan GX, Du XM and Li F: Clinicopathological and prognostic role of SIRT1 in breast cancer patients: A meta-analysis. Int J Clin Exp Med. 8:616–624. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zou Q, Tang Q, Pan Y, Wang X, Dong X, Liang Z and Huang D: MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1 Retraction in /10.3892/etm.2021.10628. Exp Ther Med 14: 1009-1016, 2017.
APA
Zou, Q., Tang, Q., Pan, Y., Wang, X., Dong, X., Liang, Z., & Huang, D. (2017). MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1 Retraction in /10.3892/etm.2021.10628. Experimental and Therapeutic Medicine, 14, 1009-1016. https://doi.org/10.3892/etm.2017.4590
MLA
Zou, Q., Tang, Q., Pan, Y., Wang, X., Dong, X., Liang, Z., Huang, D."MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1 Retraction in /10.3892/etm.2021.10628". Experimental and Therapeutic Medicine 14.2 (2017): 1009-1016.
Chicago
Zou, Q., Tang, Q., Pan, Y., Wang, X., Dong, X., Liang, Z., Huang, D."MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1 Retraction in /10.3892/etm.2021.10628". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1009-1016. https://doi.org/10.3892/etm.2017.4590
Copy and paste a formatted citation
x
Spandidos Publications style
Zou Q, Tang Q, Pan Y, Wang X, Dong X, Liang Z and Huang D: MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1 Retraction in /10.3892/etm.2021.10628. Exp Ther Med 14: 1009-1016, 2017.
APA
Zou, Q., Tang, Q., Pan, Y., Wang, X., Dong, X., Liang, Z., & Huang, D. (2017). MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1 Retraction in /10.3892/etm.2021.10628. Experimental and Therapeutic Medicine, 14, 1009-1016. https://doi.org/10.3892/etm.2017.4590
MLA
Zou, Q., Tang, Q., Pan, Y., Wang, X., Dong, X., Liang, Z., Huang, D."MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1 Retraction in /10.3892/etm.2021.10628". Experimental and Therapeutic Medicine 14.2 (2017): 1009-1016.
Chicago
Zou, Q., Tang, Q., Pan, Y., Wang, X., Dong, X., Liang, Z., Huang, D."MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1 Retraction in /10.3892/etm.2021.10628". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1009-1016. https://doi.org/10.3892/etm.2017.4590
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